Differences in cancer prevalence among

myasthenickids

Differences in cancer prevalence among CHEK2 carriers identified via multi-gene panel testing

Purpose: Although CHEK2 is a well-established cancer gene, questions remain including whether risks vary substantially between different variants and whether biallelic carriers have higher risks than heterozygotes. We report on a cohort of individuals with CHEK2 pathogenic and likely pathogenic variants (collectively, PV) in order to better characterize this gene.
Methods: We retrospectively queried samples submitted for multi-gene hereditary cancer testing to identify individuals with CHEK2 PVs and assessed differences in phenotypes among various genotypes.
Results: CHEK2 PVs were identified in 2508 individuals, including 32 individuals with biallelic CHEK2 PVs. Breast (female, 59.9% and male, 11.8%), prostate (20.1%), and colorectal (3.5%), were among the most frequently reported cancers. Select missense PVs showed similar cancer prevalence to truncating PVs while some others showed lower prevalence. No significant differences were observed between biallelic carriers and heterozygotes.
Conclusions: Our data support that some, but not all, CHEK2 missense PVs demonstrate lower cancer prevalence; further studies are needed to continue characterizing possible variant specific risks. In addition, biallelic CHEK2 PVs do not appear to be associated with a more severe phenotype than single CHEK2 PVs. Furthermore, co-occurrences with PVs in other cancer risk genes are common among CHEK2 heterozygotes and often warrant additional management.
myasthenickids
myasthenickids

PSMB8 Antibody

1-CSB-PA775839
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

PSMB8 Antibody

E043134 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody

E314816 100ug/200ul
EUR 295
Description: Available in various conjugation types.

PSMB8 Antibody

E94054 100μg
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody

E97340 100ul
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody

43134 100ul
EUR 319

PSMB8 antibody

22848 100ul
EUR 479

PSMB8 Conjugated Antibody

C43134 100ul
EUR 476.4

PSMB8 Polyclonal Antibody

A73468
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

PSMB8 Antibody, HRP conjugated

1-CSB-PA018886LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated

1-CSB-PA018886LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD05288-1ML - PSMB8 Antibody

OACD05288-1ML 1ml
EUR 649

OACD05289-1ML - PSMB8 Antibody

OACD05289-1ML 1ml
EUR 659

OACD05290-1ML - PSMB8 Antibody

OACD05290-1ML 1ml
EUR 639

OAAN02231-50UL - PSMB8 Antibody

OAAN02231-50UL 50ul
EUR 149

PSMB8 Antibody, Biotin conjugated

1-CSB-PA018886LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACD05288-100UL - PSMB8 Antibody

OACD05288-100UL 100ul
EUR 199

OACD05289-100UL - PSMB8 Antibody

OACD05289-100UL 100ul
EUR 189

OACD05290-100UL - PSMB8 Antibody

OACD05290-100UL 100ul
EUR 189

OAEB02189-100UG - PSMB8 Antibody

OAEB02189-100UG 100ug
EUR 349

OAGA01026-100UL - PSMB8 antibody

OAGA01026-100UL 100ul
EUR 369

OAAN02231-100UL - PSMB8 Antibody

OAAN02231-100UL 100ul
EUR 249

OAAN02231-200UL - PSMB8 Antibody

OAAN02231-200UL 200ul
EUR 389

PSMB8 Rabbit Polyclonal Antibody

55187 100ul
EUR 439

Monoclonal PSMB8 Antibody, Clone: 1A5

AMM02864G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Mouse Monoclonal Antibody to PSMB8

E10-30255 100ul
EUR 225
Description: Available in various conjugation types.

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211178
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211851
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx141396
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx114776
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-400ul 400 ul
EUR 627.6

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-80l 80 µl
EUR 343.2

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx006453
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx011689-100ul 100 ul
EUR 493.2

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3

AMM03954G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

OAAB10897-400UL - PSMB8 Antibody - N-terminal region

OAAB10897-400UL 400ul
EUR 389

ARP46099_P050-25UL - PSMB8 Antibody - N-terminal region

ARP46099_P050-25UL 25ul
EUR 99

ARP88638_P050-25UL - PSMB8 Antibody - N-terminal region

ARP88638_P050-25UL 25ul
EUR 99

ARP46099_P050 - PSMB8 Antibody - N-terminal region (ARP46099_P050)

ARP46099_P050 100ul
EUR 389

Psmb8/ Rat Psmb8 ELISA Kit

ELI-15652r 96 Tests
EUR 1063.2

PSMB8

enz-670 5µg
EUR 60
Description: Recombinant Human Proteasome Subunit Beta Type 8

PSMB8

E8EM1709-54 100ul
EUR 275
Description: Available in various conjugation types.

PSMB8 mouse monoclonal antibody, clone 1A5, Ascites

AM06666SU-N 100 µl Ask for price

PSMB8 siRNA

20-abx930156
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx930157
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx904317
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 Rabbit pAb

A7340-100ul 100 ul
EUR 369.6

PSMB8 Rabbit pAb

A7340-200ul 200 ul
EUR 550.8

PSMB8 Rabbit pAb

A7340-20ul 20 ul
EUR 219.6

PSMB8 Rabbit pAb

A7340-50ul 50 ul
EUR 267.6

PSMB8 Rabbit pAb

E2507340 100ul
EUR 225
Description: Available in various conjugation types.

PSMB8 Blocking Peptide

BF0434-BP 1mg
EUR 234

PSMB8/LMP7 Mouse mAb

E2220606 100ul
EUR 225
Description: Available in various conjugation types.

PSMB8 protein (His tag)

80R-2608 100 ug
EUR 386.4
Description: Purified recombinant PSMB8 protein

PSMB8 / LMP7 Rabbit pAb

E2382339 100ul
EUR 225
Description: Available in various conjugation types.

PSMB8 / LMP7 Rabbit mAb

59734 100ul
EUR 339

Canine PSMB8 ELISA KIT

ELI-15651d 96 Tests
EUR 1113.6

Rat PSMB8 shRNA Plasmid

20-abx984734
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human PSMB8 shRNA Plasmid

20-abx953843
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse PSMB8 shRNA Plasmid

20-abx971337
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

PSMB8 Recombinant Protein (Rat)

RP222629 100 ug Ask for price

PSMB8 Recombinant Protein (Mouse)

RP165287 100 ug Ask for price

PSMB8 Recombinant Protein (Human)

RP085356 100 ug Ask for price

Psmb8 ORF Vector (Rat) (pORF)

ORF074211 1.0 ug DNA
EUR 607.2

PSMB8 ORF Vector (Human) (pORF)

ORF028453 1.0 ug DNA
EUR 486

Psmb8 ORF Vector (Mouse) (pORF)

ORF055097 1.0 ug DNA
EUR 607.2

[KO Validated] PSMB8 Rabbit pAb

A19933-100ul 100 ul
EUR 492

[KO Validated] PSMB8 Rabbit pAb

A19933-200ul 200 ul
EUR 685.2

[KO Validated] PSMB8 Rabbit pAb

A19933-20ul 20 ul
EUR 265.2

[KO Validated] PSMB8 Rabbit pAb

A19933-50ul 50 ul
EUR 344.4

PSMB8 ELISA Kit (Dog) (OKEH03975)

OKEH03975 96 Wells
EUR 1012.8
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

Human PSMB8 knockout cell line

ABC-KH12324 1 vial Ask for price
Description: Human PSMB8 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

PSMB8 ELISA Kit (Human) (OKEH07770)

OKEH07770 96 Wells
EUR 1310.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

PSMB8 ELISA Kit (Human) (OKCD02695)

OKCD02695 96 Wells
EUR 950.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

Human PSMB8 knockdown cell line

ABC-KD12324 1 vial Ask for price
Description: Human PSMB8 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human PSMB8 Protein Lysate 20ug

IHUPSMB8PLLY20UG each
EUR 213
Description: Human PSMB8 Protein Lysate 20ug

OCOA13240-20UG - PSMB8 Protein Lysate

OCOA13240-20UG 20ug
EUR 169

OCOA05886-20UG - PSMB8 Protein Lysate

OCOA05886-20UG 20ug
EUR 169

OPCD04976-10UG - PSMB8 Recombinant Protein

OPCD04976-10UG 10ug
EUR 169

OPCD04976-50UG - PSMB8 Recombinant Protein

OPCD04976-50UG 50ug
EUR 409

OPCD04977-10UG - PSMB8 Recombinant Protein

OPCD04977-10UG 10ug
EUR 149

OPCD04977-50UG - PSMB8 Recombinant Protein

OPCD04977-50UG 50ug
EUR 379

OPCD04978-10UG - PSMB8 Recombinant Protein

OPCD04978-10UG 10ug
EUR 149

OPCD04978-50UG - PSMB8 Recombinant Protein

OPCD04978-50UG 50ug
EUR 359

OPCD04976-200UG - PSMB8 Recombinant Protein

OPCD04976-200UG 200ug
EUR 809

Integration of genetic counsellors in genomic testing triage: Outcomes of a Genomic Consultation Service in British Columbia, Canada

Purpose: Clinical diagnostic genome-wide (exome or genome) sequencing (GWS) in British Columbia requires funding approval by a provincial agency on a case-by-case basis. The CAUSES Clinic was a pediatric translational trio-based GWS study at BC Children’s and Women’s Hospitals.
Referrals to the CAUSES Clinic were made through a Genomic Consultation Service (GCS), a multidisciplinary team led by genetic counsellors that provided advice regarding genomic testing for physicians considering GWS for their patients.
Here we review the outcomes of the GCS, focusing on patients not recommended for the CAUSES Study.
Methods: Demographic, clinical, and testing data were abstracted from patient charts. Logistic regression analysis was used to explore associations between demographic and clinical variables and two outcomes: the type of recommendation and referring physicians’ decisions to follow the recommendation.
Results: Of 972 GCS referrals, 248 patients were not referred to the CAUSES Study. GWS (vs. a targeted test; e.g. multi-gene panel) was more likely to be recommended to physicians of patients with ID than physicians of patients without ID (OR = 2.98; 95% CI = 1.46 to 6.27; n = 149). In total, 40% of physicians who were recommended to pursue clinical genomic testing submitted an application for funding approval; 71% of applications were approved for funding. Among approved tests, 50% resulted in a diagnosis, including 33% of targeted tests and 82% of GWS tests (χ2 (1) = 5.0, p = 0.026).
Conclusion: The GCS provided an effective model in which physicians can interface with genetic specialists, including genetic counsellors, to facilitate appropriate genomic test selection.

From Probands to Relatives: Communication of Genetic Risk for Hereditary Breast-Ovarian Cancer and Its Influence on Subsequent Testing

Background: The genetic risk communication from proband to relatives varies from family to family, and patients often need support with the communication of genetic test results and making decisions to manage hereditary cancer risks.
Objective: The aim of this study was to characterize the communication of BRCA1 or BRCA2 (BRCA1/2) genetic risk from proband to first-degree relatives (FDRs) using a social network framework.
Methods: We characterized network and nonnetwork factors to explore their association with which FDRs were told about the genetic risk and whether or not relatives underwent genetic testing. Ninety-two female probands with hereditary breast and ovarian cancer who have confirmed BRCA1/2 mutations participated in the study. Communication of hereditary breast and ovarian cancer risk was assessed between 92 probands and their 417 FDRs.
Results: Of 92 probands, 94.5% (n = 87) communicated their genetic test result to at least one of their FDRs. Of FDRs older than 18 years, 19.9% (n = 72) have genetic testing. Emotional closeness, educational level of the proband, and relative’s age were significantly associated with communicating test results with FDRs.
Conclusion: Communication of genetic risk with the FDRs after having a BRCA1/2 gene-mutation-positive test result was high in this group of cancer patients. However, the rate of genetic testing among FDRs was low.
Implications for practice: Probands’ educational level and age of relatives for cascade genetic screening should be considered during counseling. Interventions to support women with BRCA1/2 mutations during the communication process and their family members’ engagement in testing and risk-reducing strategies are needed.

PSMB8 Antibody

E314816 100ug/200ul
EUR 295
Description: Available in various conjugation types.

PSMB8 Antibody

E94054 100μg
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody

E97340 100ul
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody

43134 100ul
EUR 319

PSMB8 antibody

22848 100ul
EUR 479

PSMB8 Conjugated Antibody

C43134 100ul
EUR 476.4

PSMB8 Polyclonal Antibody

A73468
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

PSMB8 Antibody, HRP conjugated

1-CSB-PA018886LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated

1-CSB-PA018886LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD05288-1ML - PSMB8 Antibody

OACD05288-1ML 1ml
EUR 649

OACD05289-1ML - PSMB8 Antibody

OACD05289-1ML 1ml
EUR 659

OACD05290-1ML - PSMB8 Antibody

OACD05290-1ML 1ml
EUR 639

OAAN02231-50UL - PSMB8 Antibody

OAAN02231-50UL 50ul
EUR 149

PSMB8 Antibody, Biotin conjugated

1-CSB-PA018886LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACD05288-100UL - PSMB8 Antibody

OACD05288-100UL 100ul
EUR 199

OACD05289-100UL - PSMB8 Antibody

OACD05289-100UL 100ul
EUR 189

OACD05290-100UL - PSMB8 Antibody

OACD05290-100UL 100ul
EUR 189

OAEB02189-100UG - PSMB8 Antibody

OAEB02189-100UG 100ug
EUR 349

OAGA01026-100UL - PSMB8 antibody

OAGA01026-100UL 100ul
EUR 369

OAAN02231-100UL - PSMB8 Antibody

OAAN02231-100UL 100ul
EUR 249

OAAN02231-200UL - PSMB8 Antibody

OAAN02231-200UL 200ul
EUR 389

PSMB8 Rabbit Polyclonal Antibody

55187 100ul
EUR 439

Monoclonal PSMB8 Antibody, Clone: 1A5

AMM02864G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Mouse Monoclonal Antibody to PSMB8

E10-30255 100ul
EUR 225
Description: Available in various conjugation types.

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211178
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211851
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx141396
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx114776
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-400ul 400 ul
EUR 627.6

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-80l 80 µl
EUR 343.2

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx006453
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx011689-100ul 100 ul
EUR 493.2

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3

AMM03954G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

OAAB10897-400UL - PSMB8 Antibody - N-terminal region

OAAB10897-400UL 400ul
EUR 389

ARP46099_P050-25UL - PSMB8 Antibody - N-terminal region

ARP46099_P050-25UL 25ul
EUR 99

ARP88638_P050-25UL - PSMB8 Antibody - N-terminal region

ARP88638_P050-25UL 25ul
EUR 99

ARP46099_P050 - PSMB8 Antibody - N-terminal region (ARP46099_P050)

ARP46099_P050 100ul
EUR 389

Psmb8/ Rat Psmb8 ELISA Kit

ELI-15652r 96 Tests
EUR 1063.2

PSMB8

enz-670 5µg
EUR 60
Description: Recombinant Human Proteasome Subunit Beta Type 8

PSMB8

E8EM1709-54 100ul
EUR 275
Description: Available in various conjugation types.

PSMB8 mouse monoclonal antibody, clone 1A5, Ascites

AM06666SU-N 100 µl Ask for price

PSMB8 siRNA

20-abx930156
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx930157
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx904317
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 Rabbit pAb

A7340-100ul 100 ul
EUR 369.6

PSMB8 Rabbit pAb

A7340-200ul 200 ul
EUR 550.8

PSMB8 Rabbit pAb

A7340-20ul 20 ul
EUR 219.6

PSMB8 Rabbit pAb

A7340-50ul 50 ul
EUR 267.6

PSMB8 Rabbit pAb

E2507340 100ul
EUR 225
Description: Available in various conjugation types.

PSMB8 Blocking Peptide

BF0434-BP 1mg
EUR 234

PSMB8/LMP7 Mouse mAb

E2220606 100ul
EUR 225
Description: Available in various conjugation types.

PSMB8 protein (His tag)

80R-2608 100 ug
EUR 386.4
Description: Purified recombinant PSMB8 protein

PSMB8 / LMP7 Rabbit pAb

E2382339 100ul
EUR 225
Description: Available in various conjugation types.

PSMB8 / LMP7 Rabbit mAb

59734 100ul
EUR 339

Canine PSMB8 ELISA KIT

ELI-15651d 96 Tests
EUR 1113.6

Rat PSMB8 shRNA Plasmid

20-abx984734
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human PSMB8 shRNA Plasmid

20-abx953843
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse PSMB8 shRNA Plasmid

20-abx971337
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

PSMB8 Recombinant Protein (Rat)

RP222629 100 ug Ask for price

PSMB8 Recombinant Protein (Mouse)

RP165287 100 ug Ask for price

PSMB8 Recombinant Protein (Human)

RP085356 100 ug Ask for price

Psmb8 ORF Vector (Rat) (pORF)

ORF074211 1.0 ug DNA
EUR 607.2

PSMB8 ORF Vector (Human) (pORF)

ORF028453 1.0 ug DNA
EUR 486

Psmb8 ORF Vector (Mouse) (pORF)

ORF055097 1.0 ug DNA
EUR 607.2

[KO Validated] PSMB8 Rabbit pAb

A19933-100ul 100 ul
EUR 492

[KO Validated] PSMB8 Rabbit pAb

A19933-200ul 200 ul
EUR 685.2

[KO Validated] PSMB8 Rabbit pAb

A19933-20ul 20 ul
EUR 265.2

[KO Validated] PSMB8 Rabbit pAb

A19933-50ul 50 ul
EUR 344.4

PSMB8 ELISA Kit (Dog) (OKEH03975)

OKEH03975 96 Wells
EUR 1012.8
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

Human PSMB8 knockout cell line

ABC-KH12324 1 vial Ask for price
Description: Human PSMB8 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

PSMB8 ELISA Kit (Human) (OKEH07770)

OKEH07770 96 Wells
EUR 1310.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

PSMB8 ELISA Kit (Human) (OKCD02695)

OKCD02695 96 Wells
EUR 950.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

Human PSMB8 knockdown cell line

ABC-KD12324 1 vial Ask for price
Description: Human PSMB8 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human PSMB8 Protein Lysate 20ug

IHUPSMB8PLLY20UG each
EUR 213
Description: Human PSMB8 Protein Lysate 20ug

OCOA13240-20UG - PSMB8 Protein Lysate

OCOA13240-20UG 20ug
EUR 169

OCOA05886-20UG - PSMB8 Protein Lysate

OCOA05886-20UG 20ug
EUR 169

OPCD04976-10UG - PSMB8 Recombinant Protein

OPCD04976-10UG 10ug
EUR 169

OPCD04976-50UG - PSMB8 Recombinant Protein

OPCD04976-50UG 50ug
EUR 409

OPCD04977-10UG - PSMB8 Recombinant Protein

OPCD04977-10UG 10ug
EUR 149

OPCD04977-50UG - PSMB8 Recombinant Protein

OPCD04977-50UG 50ug
EUR 379

OPCD04978-10UG - PSMB8 Recombinant Protein

OPCD04978-10UG 10ug
EUR 149

OPCD04978-50UG - PSMB8 Recombinant Protein

OPCD04978-50UG 50ug
EUR 359

OPCD04976-200UG - PSMB8 Recombinant Protein

OPCD04976-200UG 200ug
EUR 809

OPCD04977-200UG - PSMB8 Recombinant Protein

OPCD04977-200UG 200ug
EUR 749

OPCD04978-200UG - PSMB8 Recombinant Protein

OPCD04978-200UG 200ug
EUR 709

OKEH03975-96W - PSMB8 ELISA Kit (Dog)

OKEH03975-96W 96Wells
EUR 675

Proteasome 20S LMP7/PSMB8 Rabbit mAb

A23378 200μL
EUR 323.7
Description: A synthetic peptide corresponding to a sequence within amino acids 864-963 of human ApoER2/LRP8 (Q14114).