Differences in cancer prevalence among

myasthenickids

Differences in cancer prevalence among CHEK2 carriers identified via multi-gene panel testing

Purpose: Although CHEK2 is a well-established cancer gene, questions remain including whether risks vary substantially between different variants and whether biallelic carriers have higher risks than heterozygotes. We report on a cohort of individuals with CHEK2 pathogenic and likely pathogenic variants (collectively, PV) in order to better characterize this gene.
Methods: We retrospectively queried samples submitted for multi-gene hereditary cancer testing to identify individuals with CHEK2 PVs and assessed differences in phenotypes among various genotypes.
Results: CHEK2 PVs were identified in 2508 individuals, including 32 individuals with biallelic CHEK2 PVs. Breast (female, 59.9% and male, 11.8%), prostate (20.1%), and colorectal (3.5%), were among the most frequently reported cancers. Select missense PVs showed similar cancer prevalence to truncating PVs while some others showed lower prevalence. No significant differences were observed between biallelic carriers and heterozygotes.
Conclusions: Our data support that some, but not all, CHEK2 missense PVs demonstrate lower cancer prevalence; further studies are needed to continue characterizing possible variant specific risks. In addition, biallelic CHEK2 PVs do not appear to be associated with a more severe phenotype than single CHEK2 PVs. Furthermore, co-occurrences with PVs in other cancer risk genes are common among CHEK2 heterozygotes and often warrant additional management.
myasthenickids
myasthenickids

PSMB8 antibody

70R-13550 100 ul
EUR 457.00
Description: Affinity purified Rabbit polyclonal PSMB8 antibody

PSMB8 Antibody

1-CSB-PA775839
  • EUR 317.00
  • EUR 244.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

PSMB8 Antibody

1-CSB-PA116429
  • EUR 317.00
  • EUR 244.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

PSMB8 Antibody

1-CSB-PA018886GA01HU
  • EUR 597.00
  • EUR 333.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles. Antigen Affinity purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF

PSMB8 Antibody

1-CSB-PA018886LA01HU
  • EUR 317.00
  • EUR 335.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

PSMB8 Conjugated Antibody

C43134 100ul
EUR 397.00

Anti-PSMB8 antibody

STJ29479 100 µl
EUR 277.00
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Anti-PSMB8 antibody

STJ11100809 100 µl
EUR 413.00
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Psmb8/ Rat Psmb8 ELISA Kit

ELI-15652r 96 Tests
EUR 886.00

PSMB8 siRNA

20-abx904317
  • EUR 551.00
  • EUR 732.00
  • 0
  • 1
  • Shipped within 5-10 working days.

PSMB8 siRNA

20-abx930156
  • EUR 551.00
  • EUR 732.00
  • 0
  • 1
  • Shipped within 5-10 working days.

PSMB8 siRNA

20-abx930157
  • EUR 551.00
  • EUR 732.00
  • 0
  • 1
  • Shipped within 5-10 working days.

pOTB7-PSMB8

PVT18497 2 ug
EUR 231.00

PSMB8 Antibody, HRP conjugated

1-CSB-PA018886LB01HU
  • EUR 317.00
  • EUR 335.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated

1-CSB-PA018886LC01HU
  • EUR 317.00
  • EUR 335.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PSMB8 Antibody, Biotin conjugated

1-CSB-PA018886LD01HU
  • EUR 317.00
  • EUR 335.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

PSMB8 Blocking Peptide

BF0434-BP 1mg
EUR 195.00

PSMB8 Rabbit pAb

A7340-100ul 100 ul
EUR 308.00

PSMB8 Rabbit pAb

A7340-200ul 200 ul
EUR 459.00

PSMB8 Rabbit pAb

A7340-20ul 20 ul
EUR 183.00

PSMB8 Rabbit pAb

A7340-50ul 50 ul
EUR 223.00

anti-PSMB8 (1A5)

LF-MA30618 100 ul
EUR 527.00
Description: Mouse Monoclonal to PSMB8

Monoclonal PSMB8 Antibody, Clone: 1A5

AMM02864G 0.1ml
EUR 528.00
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Anti-PSMB8 / LMP7 Monoclonal Antibody

M02188-2 100ug
EUR 397.00
Description: Rabbit Monoclonal PSMB8 / LMP7 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Rat PSMB8 shRNA Plasmid

20-abx984734
  • EUR 801.00
  • EUR 1121.00
  • 0
  • 1
  • Shipped within 15-20 working days.

Canine PSMB8 ELISA KIT

ELI-15651d 96 Tests
EUR 928.00

Human PSMB8 shRNA Plasmid

20-abx953843
  • EUR 801.00
  • EUR 1121.00
  • 0
  • 1
  • Shipped within 15-20 working days.

PSMB8 protein (His tag)

80R-2608 100 ug
EUR 322.00
Description: Purified recombinant PSMB8 protein

Mouse PSMB8 shRNA Plasmid

20-abx971337
  • EUR 801.00
  • EUR 1121.00
  • 0
  • 1
  • Shipped within 15-20 working days.

PSMB8 Recombinant Protein (Human)

RP085356 100 ug Ask for price

PSMB8 Recombinant Protein (Rat)

RP222629 100 ug Ask for price

PSMB8 Recombinant Protein (Mouse)

RP165287 100 ug Ask for price

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3

AMM03954G 0.1mg
EUR 484.00
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx114776
  • EUR 732.00
  • EUR 398.00
  • 0
  • 1
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx141396
  • EUR 370.00
  • EUR 606.00
  • EUR 300.00
  • 0
  • 1
  • 2
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx011689-100ul 100 ul
EUR 411.00
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx006453
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 0
  • 1
  • 2
  • 3
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-400ul 400 ul
EUR 523.00
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-80l 80 µl
EUR 286.00
  • Shipped within 5-10 working days.

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211178
  • EUR 411.00
  • EUR 300.00
  • 0
  • 1
  • Shipped within 5-10 working days.

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211851
  • EUR 411.00
  • EUR 300.00
  • 0
  • 1
  • Shipped within 5-10 working days.

[KO Validated] PSMB8 Rabbit pAb

A19933-100ul 100 ul
EUR 410.00

[KO Validated] PSMB8 Rabbit pAb

A19933-200ul 200 ul
EUR 571.00

[KO Validated] PSMB8 Rabbit pAb

A19933-20ul 20 ul
EUR 221.00

[KO Validated] PSMB8 Rabbit pAb

A19933-50ul 50 ul
EUR 287.00

PSMB8 ORF Vector (Human) (pORF)

ORF028453 1.0 ug DNA
EUR 405.00

Psmb8 ORF Vector (Rat) (pORF)

ORF074211 1.0 ug DNA
EUR 506.00

Psmb8 ORF Vector (Mouse) (pORF)

ORF055097 1.0 ug DNA
EUR 506.00

PSMB8 ELISA Kit (Human) (OKCD02695)

OKCD02695 96 Wells
EUR 792.00
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

PSMB8 ELISA Kit (Dog) (OKEH03975)

OKEH03975 96 Wells
EUR 844.00
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

PSMB8 ELISA Kit (Human) (OKEH07770)

OKEH07770 96 Wells
EUR 1092.00
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

PSMB8 sgRNA CRISPR Lentivector set (Human)

K1740301 3 x 1.0 ug
EUR 339.00

Psmb8 sgRNA CRISPR Lentivector set (Mouse)

K4425601 3 x 1.0 ug
EUR 339.00

Psmb8 sgRNA CRISPR Lentivector set (Rat)

K6921501 3 x 1.0 ug
EUR 339.00

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1)

K1740302 1.0 ug DNA
EUR 154.00

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2)

K1740303 1.0 ug DNA
EUR 154.00

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3)

K1740304 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4425602 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4425603 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4425604 1.0 ug DNA
EUR 154.00

Human Proteasome subunit beta type-8 (PSMB8)

1-CSB-EP018886HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 0
  • 1
  • 2
  • 3
  • 4
  • 5
  • MW: 42.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6921502 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6921503 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6921504 1.0 ug DNA
EUR 154.00

PSMB8 Protein Vector (Human) (pPB-C-His)

PV113810 500 ng
EUR 552.00

PSMB8 Protein Vector (Human) (pPB-N-His)

PV113811 500 ng
EUR 552.00

PSMB8 Protein Vector (Human) (pPM-C-HA)

PV113812 500 ng
EUR 552.00

PSMB8 Protein Vector (Human) (pPM-C-His)

PV113813 500 ng
EUR 552.00

Recombinant Human PSMB8 Protein, His, E.coli-1mg

QP13190-1mg 1mg
EUR 2757.00

Recombinant Human PSMB8 Protein, His, E.coli-20ug

QP13190-20ug 20ug
EUR 201.00

Recombinant Human PSMB8 Protein, His, E.coli-5ug

QP13190-5ug 5ug
EUR 155.00

PSMB8 Protein Vector (Rat) (pPB-C-His)

PV296842 500 ng
EUR 603.00

PSMB8 Protein Vector (Rat) (pPB-N-His)

PV296843 500 ng
EUR 603.00

PSMB8 Protein Vector (Rat) (pPM-C-HA)

PV296844 500 ng
EUR 603.00

PSMB8 Protein Vector (Rat) (pPM-C-His)

PV296845 500 ng
EUR 603.00

PSMB8 Protein Vector (Mouse) (pPB-C-His)

PV220386 500 ng
EUR 603.00

PSMB8 Protein Vector (Mouse) (pPB-N-His)

PV220387 500 ng
EUR 603.00

PSMB8 Protein Vector (Mouse) (pPM-C-HA)

PV220388 500 ng
EUR 603.00

PSMB8 Protein Vector (Mouse) (pPM-C-His)

PV220389 500 ng
EUR 603.00

Psmb8 3'UTR GFP Stable Cell Line

TU167173 1.0 ml Ask for price

PSMB8 3'UTR Luciferase Stable Cell Line

TU019046 1.0 ml
EUR 1394.00

Psmb8 3'UTR Luciferase Stable Cell Line

TU117173 1.0 ml Ask for price

PSMB8 3'UTR GFP Stable Cell Line

TU069046 1.0 ml
EUR 1394.00

Psmb8 3'UTR GFP Stable Cell Line

TU266964 1.0 ml Ask for price

Psmb8 3'UTR Luciferase Stable Cell Line

TU216964 1.0 ml Ask for price

Integration of genetic counsellors in genomic testing triage: Outcomes of a Genomic Consultation Service in British Columbia, Canada

Purpose: Clinical diagnostic genome-wide (exome or genome) sequencing (GWS) in British Columbia requires funding approval by a provincial agency on a case-by-case basis. The CAUSES Clinic was a pediatric translational trio-based GWS study at BC Children’s and Women’s Hospitals.
Referrals to the CAUSES Clinic were made through a Genomic Consultation Service (GCS), a multidisciplinary team led by genetic counsellors that provided advice regarding genomic testing for physicians considering GWS for their patients.
Here we review the outcomes of the GCS, focusing on patients not recommended for the CAUSES Study.
Methods: Demographic, clinical, and testing data were abstracted from patient charts. Logistic regression analysis was used to explore associations between demographic and clinical variables and two outcomes: the type of recommendation and referring physicians’ decisions to follow the recommendation.
Results: Of 972 GCS referrals, 248 patients were not referred to the CAUSES Study. GWS (vs. a targeted test; e.g. multi-gene panel) was more likely to be recommended to physicians of patients with ID than physicians of patients without ID (OR = 2.98; 95% CI = 1.46 to 6.27; n = 149). In total, 40% of physicians who were recommended to pursue clinical genomic testing submitted an application for funding approval; 71% of applications were approved for funding. Among approved tests, 50% resulted in a diagnosis, including 33% of targeted tests and 82% of GWS tests (χ2 (1) = 5.0, p = 0.026).
Conclusion: The GCS provided an effective model in which physicians can interface with genetic specialists, including genetic counsellors, to facilitate appropriate genomic test selection.

From Probands to Relatives: Communication of Genetic Risk for Hereditary Breast-Ovarian Cancer and Its Influence on Subsequent Testing

Background: The genetic risk communication from proband to relatives varies from family to family, and patients often need support with the communication of genetic test results and making decisions to manage hereditary cancer risks.
Objective: The aim of this study was to characterize the communication of BRCA1 or BRCA2 (BRCA1/2) genetic risk from proband to first-degree relatives (FDRs) using a social network framework.
Methods: We characterized network and nonnetwork factors to explore their association with which FDRs were told about the genetic risk and whether or not relatives underwent genetic testing. Ninety-two female probands with hereditary breast and ovarian cancer who have confirmed BRCA1/2 mutations participated in the study. Communication of hereditary breast and ovarian cancer risk was assessed between 92 probands and their 417 FDRs.
Results: Of 92 probands, 94.5% (n = 87) communicated their genetic test result to at least one of their FDRs. Of FDRs older than 18 years, 19.9% (n = 72) have genetic testing. Emotional closeness, educational level of the proband, and relative’s age were significantly associated with communicating test results with FDRs.
Conclusion: Communication of genetic risk with the FDRs after having a BRCA1/2 gene-mutation-positive test result was high in this group of cancer patients. However, the rate of genetic testing among FDRs was low.
Implications for practice: Probands’ educational level and age of relatives for cascade genetic screening should be considered during counseling. Interventions to support women with BRCA1/2 mutations during the communication process and their family members’ engagement in testing and risk-reducing strategies are needed.

PSMB8 Antibody

1-CSB-PA775839
  • EUR 317.00
  • EUR 244.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

PSMB8 Antibody

1-CSB-PA116429
  • EUR 317.00
  • EUR 244.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

PSMB8 Antibody

1-CSB-PA018886GA01HU
  • EUR 597.00
  • EUR 333.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles. Antigen Affinity purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF

PSMB8 Antibody

1-CSB-PA018886LA01HU
  • EUR 317.00
  • EUR 335.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

PSMB8 Conjugated Antibody

C43134 100ul
EUR 397.00

Anti-PSMB8 antibody

STJ29479 100 µl
EUR 277.00
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Anti-PSMB8 antibody

STJ11100809 100 µl
EUR 413.00
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Psmb8/ Rat Psmb8 ELISA Kit

ELI-15652r 96 Tests
EUR 886.00

PSMB8 siRNA

20-abx904317
  • EUR 551.00
  • EUR 732.00
  • 0
  • 1
  • Shipped within 5-10 working days.

PSMB8 siRNA

20-abx930156
  • EUR 551.00
  • EUR 732.00
  • 0
  • 1
  • Shipped within 5-10 working days.

PSMB8 siRNA

20-abx930157
  • EUR 551.00
  • EUR 732.00
  • 0
  • 1
  • Shipped within 5-10 working days.

pOTB7-PSMB8

PVT18497 2 ug
EUR 231.00

PSMB8 Antibody, HRP conjugated

1-CSB-PA018886LB01HU
  • EUR 317.00
  • EUR 335.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated

1-CSB-PA018886LC01HU
  • EUR 317.00
  • EUR 335.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PSMB8 Antibody, Biotin conjugated

1-CSB-PA018886LD01HU
  • EUR 317.00
  • EUR 335.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

PSMB8 Blocking Peptide

BF0434-BP 1mg
EUR 195.00

PSMB8 Rabbit pAb

A7340-100ul 100 ul
EUR 308.00

PSMB8 Rabbit pAb

A7340-200ul 200 ul
EUR 459.00

PSMB8 Rabbit pAb

A7340-20ul 20 ul
EUR 183.00

PSMB8 Rabbit pAb

A7340-50ul 50 ul
EUR 223.00

anti-PSMB8 (1A5)

LF-MA30618 100 ul
EUR 527.00
Description: Mouse Monoclonal to PSMB8

Monoclonal PSMB8 Antibody, Clone: 1A5

AMM02864G 0.1ml
EUR 528.00
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Anti-PSMB8 / LMP7 Monoclonal Antibody

M02188-2 100ug
EUR 397.00
Description: Rabbit Monoclonal PSMB8 / LMP7 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Rat PSMB8 shRNA Plasmid

20-abx984734
  • EUR 801.00
  • EUR 1121.00
  • 0
  • 1
  • Shipped within 15-20 working days.

Canine PSMB8 ELISA KIT

ELI-15651d 96 Tests
EUR 928.00

Human PSMB8 shRNA Plasmid

20-abx953843
  • EUR 801.00
  • EUR 1121.00
  • 0
  • 1
  • Shipped within 15-20 working days.

PSMB8 protein (His tag)

80R-2608 100 ug
EUR 322.00
Description: Purified recombinant PSMB8 protein

Mouse PSMB8 shRNA Plasmid

20-abx971337
  • EUR 801.00
  • EUR 1121.00
  • 0
  • 1
  • Shipped within 15-20 working days.

PSMB8 Recombinant Protein (Human)

RP085356 100 ug Ask for price

PSMB8 Recombinant Protein (Rat)

RP222629 100 ug Ask for price

PSMB8 Recombinant Protein (Mouse)

RP165287 100 ug Ask for price

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3

AMM03954G 0.1mg
EUR 484.00
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx114776
  • EUR 732.00
  • EUR 398.00
  • 0
  • 1
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx141396
  • EUR 370.00
  • EUR 606.00
  • EUR 300.00
  • 0
  • 1
  • 2
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx011689-100ul 100 ul
EUR 411.00
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx006453
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 0
  • 1
  • 2
  • 3
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-400ul 400 ul
EUR 523.00
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-80l 80 µl
EUR 286.00
  • Shipped within 5-10 working days.

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211178
  • EUR 411.00
  • EUR 300.00
  • 0
  • 1
  • Shipped within 5-10 working days.

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211851
  • EUR 411.00
  • EUR 300.00
  • 0
  • 1
  • Shipped within 5-10 working days.

[KO Validated] PSMB8 Rabbit pAb

A19933-100ul 100 ul
EUR 410.00

[KO Validated] PSMB8 Rabbit pAb

A19933-200ul 200 ul
EUR 571.00

[KO Validated] PSMB8 Rabbit pAb

A19933-20ul 20 ul
EUR 221.00

[KO Validated] PSMB8 Rabbit pAb

A19933-50ul 50 ul
EUR 287.00

PSMB8 ORF Vector (Human) (pORF)

ORF028453 1.0 ug DNA
EUR 405.00

Psmb8 ORF Vector (Rat) (pORF)

ORF074211 1.0 ug DNA
EUR 506.00

Psmb8 ORF Vector (Mouse) (pORF)

ORF055097 1.0 ug DNA
EUR 506.00

PSMB8 ELISA Kit (Human) (OKCD02695)

OKCD02695 96 Wells
EUR 792.00
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

PSMB8 ELISA Kit (Dog) (OKEH03975)

OKEH03975 96 Wells
EUR 844.00
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

PSMB8 ELISA Kit (Human) (OKEH07770)

OKEH07770 96 Wells
EUR 1092.00
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

PSMB8 sgRNA CRISPR Lentivector set (Human)

K1740301 3 x 1.0 ug
EUR 339.00

Psmb8 sgRNA CRISPR Lentivector set (Mouse)

K4425601 3 x 1.0 ug
EUR 339.00

Psmb8 sgRNA CRISPR Lentivector set (Rat)

K6921501 3 x 1.0 ug
EUR 339.00

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1)

K1740302 1.0 ug DNA
EUR 154.00

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2)

K1740303 1.0 ug DNA
EUR 154.00

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3)

K1740304 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4425602 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4425603 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4425604 1.0 ug DNA
EUR 154.00

Human Proteasome subunit beta type-8 (PSMB8)

1-CSB-EP018886HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 0
  • 1
  • 2
  • 3
  • 4
  • 5
  • MW: 42.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6921502 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6921503 1.0 ug DNA
EUR 154.00

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6921504 1.0 ug DNA
EUR 154.00

PSMB8 Protein Vector (Human) (pPB-C-His)

PV113810 500 ng
EUR 552.00

PSMB8 Protein Vector (Human) (pPB-N-His)

PV113811 500 ng
EUR 552.00

PSMB8 Protein Vector (Human) (pPM-C-HA)

PV113812 500 ng
EUR 552.00

PSMB8 Protein Vector (Human) (pPM-C-His)

PV113813 500 ng
EUR 552.00

Recombinant Human PSMB8 Protein, His, E.coli-1mg

QP13190-1mg 1mg
EUR 2757.00

Recombinant Human PSMB8 Protein, His, E.coli-20ug

QP13190-20ug 20ug
EUR 201.00

Recombinant Human PSMB8 Protein, His, E.coli-5ug

QP13190-5ug 5ug
EUR 155.00

PSMB8 Protein Vector (Rat) (pPB-C-His)

PV296842 500 ng
EUR 603.00

PSMB8 Protein Vector (Rat) (pPB-N-His)

PV296843 500 ng
EUR 603.00

PSMB8 Protein Vector (Rat) (pPM-C-HA)

PV296844 500 ng
EUR 603.00

PSMB8 Protein Vector (Rat) (pPM-C-His)

PV296845 500 ng
EUR 603.00

PSMB8 Protein Vector (Mouse) (pPB-C-His)

PV220386 500 ng
EUR 603.00

PSMB8 Protein Vector (Mouse) (pPB-N-His)

PV220387 500 ng
EUR 603.00

PSMB8 Protein Vector (Mouse) (pPM-C-HA)

PV220388 500 ng
EUR 603.00

PSMB8 Protein Vector (Mouse) (pPM-C-His)

PV220389 500 ng
EUR 603.00

Psmb8 3'UTR GFP Stable Cell Line

TU167173 1.0 ml Ask for price

PSMB8 3'UTR Luciferase Stable Cell Line

TU019046 1.0 ml
EUR 1394.00

Psmb8 3'UTR Luciferase Stable Cell Line

TU117173 1.0 ml Ask for price

PSMB8 3'UTR GFP Stable Cell Line

TU069046 1.0 ml
EUR 1394.00

Psmb8 3'UTR GFP Stable Cell Line

TU266964 1.0 ml Ask for price

Psmb8 3'UTR Luciferase Stable Cell Line

TU216964 1.0 ml Ask for price

PSMB8 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV700471 1.0 ug DNA
EUR 514.00

PSMB8 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV700475 1.0 ug DNA
EUR 514.00

PSMB8 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV700476 1.0 ug DNA
EUR 514.00