Structural and useful characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase

Ivan September 8, 2020 0 Comments
myasthenickids

Structural and useful characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 perform by way of a novel non-competitive mechanism of motion

 

Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 inside particular tumor microenvironments generates an immunosuppressive area of interest that successfully renders the tumor ‘invisible’ to the host’s immune system. Elevated ARG2 expression results in a concomitant depletion of native L-arginine ranges, which in flip results in suppression of anti-tumor T-cell-mediated immune responses.

 

Right here we describe the isolation and characterization of a excessive affinity antibody (C0021158) that inhibits ARG2 enzymatic perform fully, successfully restoring T-cell proliferation in vitro. Enzyme kinetic research confirmed that C0021158 displays a noncompetitive mechanism of motion, inhibiting ARG2 independently of L-arginine concentrations.

 

To elucidate C0021158’s inhibitory mechanism at a structural degree, the co-crystal construction of the Fab in advanced with trimeric ARG2 was solved. C0021158’s epitope was consequently mapped to an space far from the enzyme’s substrate binding cleft, indicating an allosteric mechanism was being employed. Following C0021158 binding, distinct areas of ARG2 bear main conformational modifications.

 

Notably, the spine construction of a surface-exposed loop is totally rearranged, resulting in the formation of a brand new quick helix construction on the Fab-ARG2 interface. Furthermore, this large-scale structural reworking at ARG2’s epitope interprets into extra delicate modifications inside the enzyme’s lively web site. An arginine residue at place 39 is reoriented inwards, sterically impeding the binding of L-arginine. Arg39 can also be predicted to change the pOk A of a key catalytic histidine residue at place 160, additional attenuating ARG2’s enzymatic perform.

 

In silico molecular docking simulations predict that L-arginine is unable to bind successfully when antibody is certain, a prediction supported by isothermal calorimetry experiments utilizing an L-arginine mimetic. Particularly, concentrating on ARG2 within the tumor microenvironment by means of the applying of C0021158, probably together with commonplace chemotherapy regimens or alternate immunotherapies, represents a possible new technique to focus on immune chilly tumors.

 

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with PE.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with PE.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with HRP.

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4-MAA166Hu22-APC
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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with Cy3.

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4-MAA166Hu22-HRP
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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with HRP.

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4-MAA165Hu22-FITC
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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with APC-Cy7.

Pepsinogen A (PGA) Monoclonal Antibody (Rat), APC-Cy7
4-MAA165Ra21-APC-Cy7
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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with APC-Cy7.

Pepsinogen C (PGC) Monoclonal Antibody (Rat), APC-Cy7
4-MAA166Ra22-APC-Cy7
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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with APC-Cy7.

APC Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128738-INQUIRE INQUIRE Ask for price

APC Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128739-INQUIRE INQUIRE Ask for price

APC Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128740-INQUIRE INQUIRE Ask for price

APC Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128741-INQUIRE INQUIRE Ask for price

Cy3 Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128742-INQUIRE INQUIRE Ask for price

Cy3 Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128743-INQUIRE INQUIRE Ask for price

Cy3 Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128744-INQUIRE INQUIRE Ask for price

Cy3 Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128745-INQUIRE INQUIRE Ask for price

HRP Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128754-INQUIRE INQUIRE Ask for price

HRP Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128755-INQUIRE INQUIRE Ask for price

HRP Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128756-INQUIRE INQUIRE Ask for price

HRP Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128757-INQUIRE INQUIRE Ask for price

PE-Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2117857-INQUIRE INQUIRE Ask for price

APC_Cy7 Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128730-INQUIRE INQUIRE Ask for price

APC_Cy7 Linked Monoclonal Antibody to Pepsinogen A (PGA)
MBS2128731-INQUIRE INQUIRE Ask for price

Formulating monoclonal antibodies as powders for reconstitution at excessive focus utilizing spray-drying: Trehalose/amino acid combos as reconstitution time decreasing and stability enhancing formulations

 

 

To extend their stability, therapeutic (or monoclonal) antibodies (mAbs) are sometimes formulated as solids by utilizing quite a lot of drying methods, e.g. freeze-drying, spray-drying, or spray freeze-drying. The addition of excipients is required to protect stability of the protein in the course of the drying course of and subsequent storage of the ensuing strong type. The addition of low molecular weight excipients, similar to amino acids, to sugar based mostly spray- and freeze-dried formulations has been recommended to enhance the storage stability of proteins within the dried state.

 

On this examine sugars (sucrose, trehalose), amino acids (Gly, Ala, Professional, Ser, Val, Leu, Ile, Gln, His, Lys, Arg, Phe, Trp) and combos thereof have been investigated for his or her stabilizing impact throughout spray-drying and subsequent storage and for his or her reconstitution time decreasing impact.

 

Two IgG4 mAbs have been used as mannequin antibodies. From an preliminary screening examine, fundamental and small impartial amino acids, together with a sugar, similar to sucrose or trehalose, confirmed reconstitution time decreasing and stabilizing properties. Arg particularly displayed glorious reconstitution and stability enhancing properties. Furthermore, Arg was the one amino acid offering stabilizing properties akin to sucrose or trehalose.

 

Earlier work by the authors described a statistically substantiated comparability between the three fundamental amino acids in a sugar containing formulation, albeit restricted to a single focus degree [5]. Due to this fact, a follow-up design of experiments (DoE) examine was carried out to find out the optimum trehalose/amino acid content material required for an optimum protein stability and reconstitution time and to check the results of two fundamental amino acids, Lys and Arg, to these of two impartial amino acids, Gly and Professional. The performed DoE coated a variety of trehalose (30 – 120 mM) and amino acid (50 – 150 mM) concentrations.

 

The focus of trehalose was discovered to be the principle contributor to a discount in reconstitution time and a rise in stability. Right here we present that the addition of amino acids similar to Gly, Professional, and Lys doesn’t enhance stability nor does it scale back the reconstitution time. Of the examined amino acids, solely Arg confirmed a marked discount in reconstitution time and enchancment in stability in comparison with a trehalose.

 

Furthermore, the properties displayed by Arg might justify its software as the principle stabilizer in spray-dried mAb formulations, eliminating the necessity for a sugar matrix altogether. However the weight ratio of stabilizer to protein was discovered the issue exerting the strongest general affect on the formulation’s reconstitution time and stability. Extra particularly, adequate bodily stability and an appropriate reconstitution time might be obtained with a protein to stabilizer weight ratio of not less than 1:1.

 

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), Cy3
4-MAA991Mi28-Cy3
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Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with Cy3.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), HRP
4-MAA991Mi28-HRP
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  • 20ul
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Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with HRP.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), FITC
4-MAA991Mi28-FITC
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  • 20ul
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Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with FITC.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), APC-Cy7
4-MAA991Mi28-APC-Cy7
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  • 20ul
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Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with APC-Cy7.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), Biotinylated
4-MAA991Mi28-Biotin
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  • 20ul
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Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with Biotin.

PE-Linked Monoclonal Antibody to Ghrelin (GHRL)
MBS2108220-INQUIRE INQUIRE Ask for price

APC-Linked Monoclonal Antibody to Ghrelin (GHRL)
MBS2108221-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to Ghrelin (GHRL)
MBS2108222-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to Ghrelin (GHRL)
MBS2108225-INQUIRE INQUIRE Ask for price

FITC-Linked Monoclonal Antibody to Ghrelin (GHRL)
MBS2108224-INQUIRE INQUIRE Ask for price

Botin-Linked Monoclonal Antibody to Ghrelin (GHRL)
MBS2108223-INQUIRE INQUIRE Ask for price

APC/Cy7 Linked Monoclonal Antibody to Ghrelin (GHRL)
MBS2108219-INQUIRE INQUIRE Ask for price

Monoclonal GHRL / Ghrelin Antibody (clone 2F4), Clone: 2F4
AMM04782G 0.05mg
EUR 633.6
Description: A Monoclonal antibody against Human GHRL / Ghrelin (clone 2F4). The antibodies are raised in Mouse and are from clone 2F4. This antibody is applicable in WB and IHC-P, E

Monoclonal GHRL / Ghrelin Antibody (clone 4B8), Clone: 4B8
AMM04783G 0.05mg
EUR 633.6
Description: A Monoclonal antibody against Human GHRL / Ghrelin (clone 4B8). The antibodies are raised in Mouse and are from clone 4B8. This antibody is applicable in WB and IHC-P, E

Mouse monoclonal Ghrelin antibody
MBS5306169-04mL 0.4mL
EUR 3200

Mouse monoclonal Ghrelin antibody
MBS5306169-5x04mL 5x0.4mL
EUR 14245

Mouse monoclonal Ghrelin antibody
MBS5306170-04mL 0.4mL
EUR 3200

Mouse monoclonal Ghrelin antibody
MBS5306170-5x04mL 5x0.4mL
EUR 14245

Mouse monoclonal Ghrelin antibody (Biotin)
MBS5306171-015mL 0.15mL
EUR 3610

Mouse monoclonal Ghrelin antibody (Biotin)
MBS5306171-5x015mL 5x0.15mL
EUR 16090

Rat Monoclonal anti-mouse Ghrelin
mAP-0439 50ug
EUR 400

Ghrelin (10I6) Rabbit Monoclonal Antibody
E28M3324 100ul
EUR 295

Ghrelin (GHRL) Polyclonal Antibody (Mouse)
4-PAA991Mu01
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL)

Ghrelin (GHRL) Polyclonal Antibody (Mouse), PE
4-PAA991Mu01-PE
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with PE.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), APC
4-PAA991Mu01-APC
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with APC.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), Cy3
4-PAA991Mu01-Cy3
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  • 20ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with Cy3.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), HRP
4-PAA991Mu01-HRP
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  • 20ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with HRP.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), FITC
4-PAA991Mu01-FITC
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  • 20ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with FITC.

Ghrelin (GHRL) Antibody
abx132316-100tests 100 tests
EUR 287.5

Ghrelin (GHRL) Antibody
abx129314-100l 100 µl
EUR 262.5

Ghrelin (GHRL) Antibody
20-abx129314
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  • 10 ug
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  • 1 mg

Ghrelin (GHRL) Antibody
abx129314-1ml 1 ml
EUR 687.5

Ghrelin (GHRL) Antibody
abx129314-200l 200 µl
EUR 325

Ghrelin (GHRL) Antibody
abx100169-100l 100 µl
EUR 250

Ghrelin (GHRL) Antibody
20-abx100169
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  • 10 ug
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Ghrelin (GHRL) Antibody
abx100169-1ml 1 ml
EUR 675

Ghrelin (GHRL) Antibody
abx100169-200l 200 µl
EUR 312.5

Ghrelin (GHRL) Antibody
20-abx176583
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  • 10 ug
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Ghrelin (GHRL) Antibody
abx176583-1096tests 10 × 96 tests
EUR 675

Ghrelin (GHRL) Antibody
abx176583-596tests 5 × 96 tests
EUR 312.5

Ghrelin (GHRL) Antibody
abx176583-96tests 96 tests
EUR 250

Ghrelin (GHRL) Antibody
20-abx176584
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  • 10 ug
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Ghrelin (GHRL) Antibody
abx176584-1096tests 10 × 96 tests
EUR 687.5

Ghrelin (GHRL) Antibody
abx176584-596tests 5 × 96 tests
EUR 325

Ghrelin (GHRL) Antibody
abx176584-96tests 96 tests
EUR 262.5

Ghrelin (GHRL) Antibody
20-abx176585
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  • 10 ug
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Ghrelin (GHRL) Antibody
abx176585-1096tests 10 × 96 tests
EUR 725

Ghrelin (GHRL) Antibody
abx176585-596tests 5 × 96 tests
EUR 337.5

Ghrelin (GHRL) Antibody
abx176585-96tests 96 tests
EUR 262.5

Ghrelin (GHRL) Antibody
abx328383-100g 100 µg
EUR 250

Ghrelin (GHRL) Antibody
20-abx328383
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Ghrelin (GHRL) Antibody
abx328383-50g 50 µg
EUR 187.5

Ghrelin (GHRL) Polyclonal Antibody (Mouse), Biotinylated
4-PAA991Mu01-Biotin
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with Biotin.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), APC-Cy7
4-PAA991Mu01-APC-Cy7
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  • 20ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with APC-Cy7.

Rat Monoclonal anti-mouse Obestatin (Ghrelin prepropeptide)
mAP-0490 50ug
EUR 400

Monoclonal Anti-Human Ghrelin IgG # 3, aff pure
GHS13-M 100 ug
EUR 578.4

Ghrl (untagged) - Mouse ghrelin (Ghrl), (10ug)
MC208061 10 µg Ask for price

Ghrelin (GHRL) Antibody (Biotin)
20-abx272533
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  • 10 ug
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  • 1 mg

Ghrelin (GHRL) Antibody (Biotin)
abx272533-1ml 1 ml
EUR 737.5

Ghrelin (GHRL) Antibody (Biotin)
abx272533-200l 200 µl
EUR 337.5

Mouse Ghrelin (GHRL) Antibody Pair Kit (with Standard)
MBS2099758-10x96Tests 10x96Tests
EUR 1375

Mouse Ghrelin (GHRL) Antibody Pair Kit (with Standard)
MBS2099758-10x96TestsMBS2090685AbPairsSupportPack110x96Tests 10x96Tests+MBS2090685(AbPairsSupportPack1,10x96Tests)
EUR 1500

Mouse Ghrelin (GHRL) Antibody Pair Kit (with Standard)
MBS2099758-5x96Tests 5x96Tests
EUR 875

Mouse Ghrelin (GHRL) Antibody Pair Kit (with Standard)
MBS2099758-5x96TestsMBS2090685AbPairsSupportPack15x96Tests 5x96Tests+MBS2090685(AbPairsSupportPack1,5x96Tests)
EUR 950

Mouse Ghrelin (GHRL) Antibody Pair Kit (with Standard)
MBS2099759-10x96Tests 10x96Tests
EUR 1630

Mouse Ghrelin (GHRL) Antibody Pair Kit (with Standard)
MBS2099759-10x96TestsMBS2090686AbPairsSupportPack210x96Tests 10x96Tests+MBS2090686(AbPairsSupportPack2,10x96Tests)
EUR 1750

Mouse Ghrelin (GHRL) Antibody Pair Kit (with Standard)
MBS2099759-5x96Tests 5x96Tests
EUR 1030

Mouse Ghrelin (GHRL) Antibody Pair Kit (with Standard)
MBS2099759-5x96TestsMBS2090686AbPairsSupportPack25x96Tests 5x96Tests+MBS2090686(AbPairsSupportPack2,5x96Tests)
EUR 1100

Ghrelin (GHRL) Polyclonal Antibody
CAU31321-100ul 100ul
EUR 211.2

Ghrelin (GHRL) Polyclonal Antibody
CAU31321-200ul 200ul
EUR 263.8

Ghrelin (GHRL) Polyclonal Antibody
CAU31322-100ul 100ul
EUR 217.9

Ghrelin (GHRL) Polyclonal Antibody
CAU31322-200ul 200ul
EUR 272.2

Ghrelin (GHRL) Polyclonal Antibody
CAU31323-100ul 100ul
EUR 229.4

Ghrelin (GHRL) Polyclonal Antibody
CAU31323-200ul 200ul
EUR 287.3

Ghrelin (GHRL) Polyclonal Antibody
CAU26710-100ul 100ul
EUR 217.9

Ghrelin (GHRL) Polyclonal Antibody
CAU26710-200ul 200ul
EUR 272.2

Ghrelin (GHRL) Polyclonal Antibody
CAU26711-100ul 100ul
EUR 212.2

Ghrelin (GHRL) Polyclonal Antibody
CAU26711-200ul 200ul
EUR 265.4

Mouse Ghrelin (GHRL) Protein
abx167204-100g 100 µg
EUR 512.5

Mouse Ghrelin (GHRL) Protein
20-abx167204
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  • 10 ug
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  • 1 mg

Mouse Ghrelin (GHRL) Protein
abx167204-10g 10 µg
EUR 212.5

Mouse Ghrelin (GHRL) Protein
abx167204-50g 50 µg
EUR 362.5

Ghrl (Myc-DDK-tagged) - Mouse ghrelin (Ghrl)
MR212134 10 µg Ask for price

Polyclonal Antibody to Ghrelin (GHRL)
MBS2003046-01mL 0.1mL
EUR 165

Polyclonal Antibody to Ghrelin (GHRL)
MBS2003046-02mL 0.2mL
EUR 200

Polyclonal Antibody to Ghrelin (GHRL)
MBS2003046-05mL 0.5mL
EUR 325

Polyclonal Antibody to Ghrelin (GHRL)
MBS2003046-1mL 1mL
EUR 395

Polyclonal Antibody to Ghrelin (GHRL)
MBS2003046-5mL 5mL
EUR 1075

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112060-01mL 0.1mL
EUR 165

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112060-02mL 0.2mL
EUR 200

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112060-05mL 0.5mL
EUR 320

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112060-1mL 1mL
EUR 395

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112060-5mL 5mL
EUR 1070

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112061-01mL 0.1mL
EUR 170

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112061-02mL 0.2mL
EUR 205

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112061-05mL 0.5mL
EUR 330

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112061-1mL 1mL
EUR 405

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112061-5mL 5mL
EUR 1100

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112062-01mL 0.1mL
EUR 170

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112062-02mL 0.2mL
EUR 215

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112062-05mL 0.5mL
EUR 350

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112062-1mL 1mL
EUR 425

Polyclonal Antibody to Ghrelin (GHRL)
MBS2112062-5mL 5mL
EUR 1160

Polyclonal Antibody to Ghrelin (GHRL)
MBS2027885-01mL 0.1mL
EUR 170

Polyclonal Antibody to Ghrelin (GHRL)
MBS2027885-02mL 0.2mL
EUR 205

Polyclonal Antibody to Ghrelin (GHRL)
MBS2027885-05mL 0.5mL
EUR 330

Polyclonal Antibody to Ghrelin (GHRL)
MBS2027885-1mL 1mL
EUR 405

Polyclonal Antibody to Ghrelin (GHRL)
MBS2027885-5mL 5mL
EUR 1100

Mouse Ghrelin (GHRL) CLIA Kit
20-abx496443
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  • 96 tests
  • 5 × 96 tests
  • 10 × 96 tests

Mouse Ghrelin (GHRL) CLIA Kit
20-abx490342
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  • 96 tests
  • 5 × 96 tests
  • 10 × 96 tests

Mouse Ghrelin (GHRL) ELISA Kit
20-abx154080
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  • 96 tests
  • 5 × 96 tests
  • 10 × 96 tests

Mouse Ghrelin (GHRL) ELISA Kit
CEA991Mu-10x96wellstestplate 10x96-wells test plate
EUR 5269.39
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit
CEA991Mu-1x48wellstestplate 1x48-wells test plate
EUR 539.12
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit
CEA991Mu-1x96wellstestplate 1x96-wells test plate
EUR 718.75
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit
CEA991Mu-5x96wellstestplate 5x96-wells test plate
EUR 2874.38
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit
4-CEA991Mu
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  • 1 plate of 96 wells
  • 5 plates of 96 wells
  • 10 plates of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse ghrelin (GHRL) ELISA Kit
CSB-E09817m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse ghrelin (GHRL) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse ghrelin (GHRL) ELISA Kit
CSB-E09817m-48T 48T
EUR 407.06
Description: Mus musculus (Mouse)

Mouse ghrelin (GHRL) ELISA Kit
1-CSB-E09817m
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  • 1 plate of 96 wells
  • 5 plates of 96 wells each
  • 10 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse ghrelin (GHRL) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse ghrelin (GHRL) ELISA Kit
CSB-E09817m-96T 96T
EUR 626.25
Description: Mus musculus (Mouse)

Mouse Ghrelin (GHRL) ELISA Kit
abx350732-96tests 96 tests
EUR 587.5

Mouse Ghrelin (GHRL) ELISA Kit
DLR-GHRL-Mu 96T
EUR 432
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit
DLR-GHRL-Mu-48T 48T
EUR 586.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit
DLR-GHRL-Mu-96T 96T
EUR 762
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit
20-abx258875
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  • 96 tests
  • 5 × 96 tests
  • 10 × 96 tests

Mouse Ghrelin (GHRL) ELISA Kit
abx258875-1mg 1 mg
EUR 6187.5

Mouse Ghrelin (GHRL) ELISA Kit
abx258875-20g 20 µg
EUR 3275

Mouse Ghrelin (GHRL) ELISA Kit
abx258875-5g 5 µg
EUR 687.5

Mouse Ghrelin (GHRL) ELISA Kit
DL-GHRL-Mu 96T
EUR 412
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit
EKU11130-48T 48T
EUR 617.68

Mouse Ghrelin (GHRL) ELISA Kit
EKU11130-5x96T 5x96T
EUR 4191.4

Mouse Ghrelin (GHRL) ELISA Kit
EKU11130-96T 96T
EUR 882.4

Mouse Ghrelin (GHRL) ELISA Kit
EKU04362-48T 48T
EUR 514.08

Mouse Ghrelin (GHRL) ELISA Kit
EKU04362-5x96T 5x96T
EUR 3488.4

Mouse Ghrelin (GHRL) ELISA Kit
EKU04362-96T 96T
EUR 734.4

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