Structural and useful characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase

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myasthenickids

Structural and useful characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 perform by way of a novel non-competitive mechanism of motion

 

Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 inside particular tumor microenvironments generates an immunosuppressive area of interest that successfully renders the tumor ‘invisible’ to the host’s immune system. Elevated ARG2 expression results in a concomitant depletion of native L-arginine ranges, which in flip results in suppression of anti-tumor T-cell-mediated immune responses.

 

Right here we describe the isolation and characterization of a excessive affinity antibody (C0021158) that inhibits ARG2 enzymatic perform fully, successfully restoring T-cell proliferation in vitro. Enzyme kinetic research confirmed that C0021158 displays a noncompetitive mechanism of motion, inhibiting ARG2 independently of L-arginine concentrations.

 

To elucidate C0021158’s inhibitory mechanism at a structural degree, the co-crystal construction of the Fab in advanced with trimeric ARG2 was solved. C0021158’s epitope was consequently mapped to an space far from the enzyme’s substrate binding cleft, indicating an allosteric mechanism was being employed. Following C0021158 binding, distinct areas of ARG2 bear main conformational modifications.

 

Notably, the spine construction of a surface-exposed loop is totally rearranged, resulting in the formation of a brand new quick helix construction on the Fab-ARG2 interface. Furthermore, this large-scale structural reworking at ARG2’s epitope interprets into extra delicate modifications inside the enzyme’s lively web site. An arginine residue at place 39 is reoriented inwards, sterically impeding the binding of L-arginine. Arg39 can also be predicted to change the pOk A of a key catalytic histidine residue at place 160, additional attenuating ARG2’s enzymatic perform.

 

In silico molecular docking simulations predict that L-arginine is unable to bind successfully when antibody is certain, a prediction supported by isothermal calorimetry experiments utilizing an L-arginine mimetic. Particularly, concentrating on ARG2 within the tumor microenvironment by means of the applying of C0021158, probably together with commonplace chemotherapy regimens or alternate immunotherapies, represents a possible new technique to focus on immune chilly tumors.

 

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  • 100 ug
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  • 1 mg
  • 200 ug
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
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  • EUR 4677.00
  • EUR 2471.00
  • EUR 627.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Rat Pepsin (PP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

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  • EUR 2526.00
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
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  • EUR 5574.00
  • EUR 2945.00
  • EUR 733.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mini Samples Mouse Pepsin (PP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

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  • EUR 527.00
  • EUR 5818.00
  • EUR 1552.00
  • EUR 698.00
  • EUR 301.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
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EUR 584
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EUR 534
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EUR 584
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EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Rat PP (Pepsin) in samples from Serum, Plasma, Cell supernatant

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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

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T6235090-PP 5 slides x2
EUR 599
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Matching Pair - Frozen Tissue Section - Human Primary Tumor and Normal (PP): Kidney

T6235142-PP 5 slides x2
EUR 599
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Matching Pair - Frozen Tissue Section - Human Primary Tumor and Normal (PP): Liver

T6235149-PP 5 slides x2
EUR 599
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Formulating monoclonal antibodies as powders for reconstitution at excessive focus utilizing spray-drying: Trehalose/amino acid combos as reconstitution time decreasing and stability enhancing formulations

 

 

To extend their stability, therapeutic (or monoclonal) antibodies (mAbs) are sometimes formulated as solids by utilizing quite a lot of drying methods, e.g. freeze-drying, spray-drying, or spray freeze-drying. The addition of excipients is required to protect stability of the protein in the course of the drying course of and subsequent storage of the ensuing strong type. The addition of low molecular weight excipients, similar to amino acids, to sugar based mostly spray- and freeze-dried formulations has been recommended to enhance the storage stability of proteins within the dried state.

 

On this examine sugars (sucrose, trehalose), amino acids (Gly, Ala, Professional, Ser, Val, Leu, Ile, Gln, His, Lys, Arg, Phe, Trp) and combos thereof have been investigated for his or her stabilizing impact throughout spray-drying and subsequent storage and for his or her reconstitution time decreasing impact.

 

Two IgG4 mAbs have been used as mannequin antibodies. From an preliminary screening examine, fundamental and small impartial amino acids, together with a sugar, similar to sucrose or trehalose, confirmed reconstitution time decreasing and stabilizing properties. Arg particularly displayed glorious reconstitution and stability enhancing properties. Furthermore, Arg was the one amino acid offering stabilizing properties akin to sucrose or trehalose.

 

Earlier work by the authors described a statistically substantiated comparability between the three fundamental amino acids in a sugar containing formulation, albeit restricted to a single focus degree [5]. Due to this fact, a follow-up design of experiments (DoE) examine was carried out to find out the optimum trehalose/amino acid content material required for an optimum protein stability and reconstitution time and to check the results of two fundamental amino acids, Lys and Arg, to these of two impartial amino acids, Gly and Professional. The performed DoE coated a variety of trehalose (30 – 120 mM) and amino acid (50 – 150 mM) concentrations.

 

The focus of trehalose was discovered to be the principle contributor to a discount in reconstitution time and a rise in stability. Right here we present that the addition of amino acids similar to Gly, Professional, and Lys doesn’t enhance stability nor does it scale back the reconstitution time. Of the examined amino acids, solely Arg confirmed a marked discount in reconstitution time and enchancment in stability in comparison with a trehalose.

 

Furthermore, the properties displayed by Arg might justify its software as the principle stabilizer in spray-dried mAb formulations, eliminating the necessity for a sugar matrix altogether. However the weight ratio of stabilizer to protein was discovered the issue exerting the strongest general affect on the formulation’s reconstitution time and stability. Extra particularly, adequate bodily stability and an appropriate reconstitution time might be obtained with a protein to stabilizer weight ratio of not less than 1:1.

 

Human Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Hu-48T 48T
EUR 479
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Hu-96T 96T
EUR 621
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Ghrelin (GHRL) ELISA Kit

DLR-GHRL-p-48T 48T
EUR 547
Description: A competitive inhibition quantitative ELISA assay kit for detection of Porcine Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Ghrelin (GHRL) ELISA Kit

DLR-GHRL-p-96T 96T
EUR 715
Description: A competitive inhibition quantitative ELISA assay kit for detection of Porcine Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Ra-48T 48T
EUR 508
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Ra-96T 96T
EUR 661
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Sheep Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Sh-48T 48T
EUR 576
Description: A competitive inhibition quantitative ELISA assay kit for detection of Sheep Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Sheep Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Sh-96T 96T
EUR 755
Description: A competitive inhibition quantitative ELISA assay kit for detection of Sheep Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Ch-48Tests 48 Tests
EUR 534

Chicken Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Ch-96Tests 96 Tests
EUR 742

Human Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Hu-48Tests 48 Tests
EUR 500

Human Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Hu-96Tests 96 Tests
EUR 692

Porcine Ghrelin (GHRL) ELISA Kit

RDR-GHRL-p-48Tests 48 Tests
EUR 580

Porcine Ghrelin (GHRL) ELISA Kit

RDR-GHRL-p-96Tests 96 Tests
EUR 807

Rat Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Ra-48Tests 48 Tests
EUR 534

Rat Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Ra-96Tests 96 Tests
EUR 742

Sheep Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Sh-48Tests 48 Tests
EUR 614

Sheep Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Sh-96Tests 96 Tests
EUR 856

Chicken Ghrelin (GHRL) ELISA Kit

RD-GHRL-Ch-48Tests 48 Tests
EUR 511

Chicken Ghrelin (GHRL) ELISA Kit

RD-GHRL-Ch-96Tests 96 Tests
EUR 709

Human Ghrelin (GHRL) ELISA Kit

RD-GHRL-Hu-48Tests 48 Tests
EUR 478

Human Ghrelin (GHRL) ELISA Kit

RD-GHRL-Hu-96Tests 96 Tests
EUR 662

Porcine Ghrelin (GHRL) ELISA Kit

RD-GHRL-p-48Tests 48 Tests
EUR 555

Porcine Ghrelin (GHRL) ELISA Kit

RD-GHRL-p-96Tests 96 Tests
EUR 771

Rat Ghrelin (GHRL) ELISA Kit

RD-GHRL-Ra-48Tests 48 Tests
EUR 511

Rat Ghrelin (GHRL) ELISA Kit

RD-GHRL-Ra-96Tests 96 Tests
EUR 709

Sheep Ghrelin (GHRL) ELISA Kit

RD-GHRL-Sh-48Tests 48 Tests
EUR 587

Sheep Ghrelin (GHRL) ELISA Kit

RD-GHRL-Sh-96Tests 96 Tests
EUR 818

Ghrelin (GHRL) Antibody

20-abx176583
  • EUR 398.00
  • EUR 133.00
  • EUR 1094.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx176584
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx176585
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx100169
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx129314
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx328383
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog)

4-MAA991Mi28
  • EUR 259.00
  • EUR 2708.00
  • EUR 670.00
  • EUR 328.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL)

Ghrelin (GHRL) Polyclonal Antibody (Mouse)

4-PAA991Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL)

Mouse Ghrelin (GHRL) Protein

20-abx167204
  • EUR 620.00
  • EUR 272.00
  • EUR 1859.00
  • EUR 732.00
  • EUR 453.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody (Biotin)

20-abx272533
  • EUR 425.00
  • EUR 230.00
  • EUR 1191.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Recombinant Ghrelin (GHRL)

4-RPA991Hu01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Ghrelin expressed in: E.coli

Recombinant Ghrelin (GHRL)

4-RPA991Mu01
  • EUR 440.48
  • EUR 221.00
  • EUR 1376.80
  • EUR 525.60
  • EUR 951.20
  • EUR 358.00
  • EUR 3292.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Ghrelin expressed in: E.coli

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), APC

4-MAA991Mi28-APC
  • EUR 364.00
  • EUR 3545.00
  • EUR 980.00
  • EUR 467.00
  • EUR 227.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with APC.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), Biotinylated

4-MAA991Mi28-Biotin
  • EUR 325.00
  • EUR 2658.00
  • EUR 777.00
  • EUR 400.00
  • EUR 225.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with Biotin.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), Cy3

4-MAA991Mi28-Cy3
  • EUR 444.00
  • EUR 4685.00
  • EUR 1265.00
  • EUR 581.00
  • EUR 261.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with Cy3.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), FITC

4-MAA991Mi28-FITC
  • EUR 311.00
  • EUR 2856.00
  • EUR 804.00
  • EUR 393.00
  • EUR 202.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with FITC.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), HRP

4-MAA991Mi28-HRP
  • EUR 332.00
  • EUR 3089.00
  • EUR 866.00
  • EUR 421.00
  • EUR 213.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with HRP.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), PE

4-MAA991Mi28-PE
  • EUR 311.00
  • EUR 2856.00
  • EUR 804.00
  • EUR 393.00
  • EUR 202.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with PE.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), APC

4-PAA991Mu01-APC
  • EUR 329.00
  • EUR 3041.00
  • EUR 854.00
  • EUR 416.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with APC.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), Biotinylated

4-PAA991Mu01-Biotin
  • EUR 299.00
  • EUR 2288.00
  • EUR 684.00
  • EUR 363.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with Biotin.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), Cy3

4-PAA991Mu01-Cy3
  • EUR 397.00
  • EUR 4013.00
  • EUR 1097.00
  • EUR 513.00
  • EUR 241.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with Cy3.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), FITC

4-PAA991Mu01-FITC
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with FITC.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), HRP

4-PAA991Mu01-HRP
  • EUR 302.00
  • EUR 2652.00
  • EUR 756.00
  • EUR 377.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with HRP.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), PE

4-PAA991Mu01-PE
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with PE.

Monoclonal GHRL / Ghrelin Antibody (clone 2F4), Clone: 2F4

AMM04782G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human GHRL / Ghrelin (clone 2F4). The antibodies are raised in Mouse and are from clone 2F4. This antibody is applicable in WB and IHC-P, E

Monoclonal GHRL / Ghrelin Antibody (clone 4B8), Clone: 4B8

AMM04783G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human GHRL / Ghrelin (clone 4B8). The antibodies are raised in Mouse and are from clone 4B8. This antibody is applicable in WB and IHC-P, E

Mouse Ghrelin (GHRL) ELISA Kit

20-abx154080
  • EUR 6642.00
  • EUR 3542.00
  • EUR 825.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Ghrelin (GHRL) ELISA Kit

20-abx258875
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Ghrelin (GHRL) ELISA Kit

CEA991Mu-10x96wellstestplate 10x96-wells test plate
EUR 4391.16
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

CEA991Mu-1x48wellstestplate 1x48-wells test plate
EUR 449.27
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

CEA991Mu-1x96wellstestplate 1x96-wells test plate
EUR 598.96
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

CEA991Mu-5x96wellstestplate 5x96-wells test plate
EUR 2395.32
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

4-CEA991Mu
  • EUR 4442.00
  • EUR 2346.00
  • EUR 599.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse ghrelin (GHRL) ELISA Kit

CSB-E09817m-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Mouse ghrelin (GHRL) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse ghrelin (GHRL) ELISA Kit

1-CSB-E09817m
  • EUR 946.00
  • EUR 5782.00
  • EUR 3060.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse ghrelin (GHRL) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Ghrelin (GHRL) Protein (BSA)

20-abx651193
  • EUR 314.00
  • EUR 203.00
  • EUR 801.00
  • EUR 356.00
  • EUR 258.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Ghrelin (GHRL) Protein (OVA)

20-abx651194
  • EUR 314.00
  • EUR 203.00
  • EUR 801.00
  • EUR 356.00
  • EUR 258.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Ghrelin (GHRL) CLIA Kit

20-abx490342
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Ghrelin (GHRL) CLIA Kit

20-abx496443
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Ghrelin (GHRL) ELISA Kit

SEA991Mu-10x96wellstestplate 10x96-wells test plate
EUR 4862.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

SEA991Mu-1x48wellstestplate 1x48-wells test plate
EUR 488.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

SEA991Mu-1x96wellstestplate 1x96-wells test plate
EUR 654.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

SEA991Mu-5x96wellstestplate 5x96-wells test plate
EUR 2644.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

4-SEA991Mu
  • EUR 4913.00
  • EUR 2595.00
  • EUR 655.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Ghrelin ELISA Kit (GHRL)

RK02847 96 Tests
EUR 521

Ghrelin/Obestatin Preprohormone (GHRL) Antibody

20-abx176586
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin/Obestatin Preprohormone (GHRL) Antibody

20-abx176587
  • EUR 1302.00
  • EUR 620.00
  • 1 mg
  • 200 ug

Ghrelin/Obestatin Preprohormone (GHRL) Antibody

20-abx172536
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Ghrelin/Obestatin Preprohormone (GHRL) Antibody

20-abx172537
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Ghrelin (GHRL) Polyclonal Antibody (Human)

4-PAA991Hu01
  • EUR 232.00
  • EUR 2285.00
  • EUR 574.00
  • EUR 289.00
  • EUR 208.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ghrelin (GHRL)

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), APC-Cy7

4-MAA991Mi28-APC-Cy7
  • EUR 608.00
  • EUR 6970.00
  • EUR 1840.00
  • EUR 814.00
  • EUR 335.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with APC-Cy7.

Human Ghrelin (GHRL) Protein

20-abx166417
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

BSA Conjugated Ghrelin (GHRL)

4-CPA991Hu11
  • EUR 226.34
  • EUR 163.00
  • EUR 573.76
  • EUR 257.92
  • EUR 415.84
  • EUR 214.00
  • EUR 1284.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Ghrelin expressed in: Protein conjugation

OVA Conjugated Ghrelin (GHRL)

4-CPA991Hu21
  • EUR 226.34
  • EUR 163.00
  • EUR 573.76
  • EUR 257.92
  • EUR 415.84
  • EUR 214.00
  • EUR 1284.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Ghrelin expressed in: Protein conjugation

BSA Conjugated Ghrelin (GHRL)

4-CPA991Mu11
  • EUR 226.34
  • EUR 163.00
  • EUR 573.76
  • EUR 257.92
  • EUR 415.84
  • EUR 214.00
  • EUR 1284.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Ghrelin expressed in: Protein conjugation

OVA Conjugated Ghrelin (GHRL)

4-CPA991Mu21
  • EUR 226.34
  • EUR 163.00
  • EUR 573.76
  • EUR 257.92
  • EUR 415.84
  • EUR 214.00
  • EUR 1284.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Ghrelin expressed in: Protein conjugation

BSA Conjugated Ghrelin (GHRL)

4-CPA991Ra11
  • EUR 226.34
  • EUR 163.00
  • EUR 573.76
  • EUR 257.92
  • EUR 415.84
  • EUR 214.00
  • EUR 1284.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Ghrelin expressed in: Protein conjugation

OVA Conjugated Ghrelin (GHRL)

4-CPA991Ra21
  • EUR 226.34
  • EUR 163.00
  • EUR 573.76
  • EUR 257.92
  • EUR 415.84
  • EUR 214.00
  • EUR 1284.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Ghrelin expressed in: Protein conjugation

GHRL Ghrelin Human protein

PROTQ9UBU3-1 Regular: 10mg
EUR 577
Description: Ghrelin Human contains 28 amino acids and a total molecular mass of 3370.9 Dalton and a molecular formula of C149H249N47O42.;The GHRL is purified by proprietary chromatographic techniques.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA991Mu01-APC-Cy7
  • EUR 538.00
  • EUR 5962.00
  • EUR 1588.00
  • EUR 713.00
  • EUR 304.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with APC-Cy7.

ELISA kit for Mouse GHRL (Ghrelin)

E-EL-M0551 1 plate of 96 wells
EUR 534
Description: A competitive ELISA kit for quantitative measurement of Mouse GHRL (Ghrelin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse GHRL (Ghrelin)

ELK1945 1 plate of 96 wells
EUR 432
Description: A competitive Inhibition ELISA kit for detection of Ghrelin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Mouse GHRL (Ghrelin)

ELK7751 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Ghrelin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Polyclonal GHRL / Ghrelin Antibody (C-Terminus)

AMM04781G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human GHRL / Ghrelin (C-Terminus). This antibody is tested and proven to work in the following applications:

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