Structural and useful characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase

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myasthenickids

Structural and useful characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 perform by way of a novel non-competitive mechanism of motion

 

Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 inside particular tumor microenvironments generates an immunosuppressive area of interest that successfully renders the tumor ‘invisible’ to the host’s immune system. Elevated ARG2 expression results in a concomitant depletion of native L-arginine ranges, which in flip results in suppression of anti-tumor T-cell-mediated immune responses.

 

Right here we describe the isolation and characterization of a excessive affinity antibody (C0021158) that inhibits ARG2 enzymatic perform fully, successfully restoring T-cell proliferation in vitro. Enzyme kinetic research confirmed that C0021158 displays a noncompetitive mechanism of motion, inhibiting ARG2 independently of L-arginine concentrations.

 

To elucidate C0021158’s inhibitory mechanism at a structural degree, the co-crystal construction of the Fab in advanced with trimeric ARG2 was solved. C0021158’s epitope was consequently mapped to an space far from the enzyme’s substrate binding cleft, indicating an allosteric mechanism was being employed. Following C0021158 binding, distinct areas of ARG2 bear main conformational modifications.

 

Notably, the spine construction of a surface-exposed loop is totally rearranged, resulting in the formation of a brand new quick helix construction on the Fab-ARG2 interface. Furthermore, this large-scale structural reworking at ARG2’s epitope interprets into extra delicate modifications inside the enzyme’s lively web site. An arginine residue at place 39 is reoriented inwards, sterically impeding the binding of L-arginine. Arg39 can also be predicted to change the pOk A of a key catalytic histidine residue at place 160, additional attenuating ARG2’s enzymatic perform.

 

In silico molecular docking simulations predict that L-arginine is unable to bind successfully when antibody is certain, a prediction supported by isothermal calorimetry experiments utilizing an L-arginine mimetic. Particularly, concentrating on ARG2 within the tumor microenvironment by means of the applying of C0021158, probably together with commonplace chemotherapy regimens or alternate immunotherapies, represents a possible new technique to focus on immune chilly tumors.

 

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with PE.

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with PE.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with PE.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with APC-Cy7.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with APC-Cy7.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with APC-Cy7.

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with APC-Cy7.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with APC-Cy7.

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Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with Biotin.

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4-MAA165Ra21-Biotin
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Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with Biotin.

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Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with Biotin.

Pepsin (PP) Antibody (Biotin)

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Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with Biotin.

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Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with Biotin.

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EUR 211.2

Pepsin (PP) Polyclonal Antibody

CAU31174-200ul 200ul
EUR 263.8

Mouse Monoclonal anti-human PP

hAP-0858 50ug
EUR 400

Polyclonal Antibody to Pepsin (PP)

PAA632Hu01 100ul
EUR 221

Polyclonal Antibody to Pepsin (PP)

PAA632Hu02 100ul
EUR 220

Polyclonal Antibody to Pepsin (PP)

PAA632Hu08 100ul
EUR 220

Polyclonal Antibody to Pepsin (PP)

PAA632Hu09 100ul
EUR 220

Pepsin (PP) Polyclonal Antibody (Human)

4-PAA632Hu01
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  • 100ul
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  • 20ul
Description: A Rabbit polyclonal antibody against Human Pepsin (PP)

Mouse Pepsin (PP) CLIA Kit

20-abx490191
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Pepsin (PP) CLIA Kit

abx196164-96tests 96 tests
EUR 990

Mouse PP -Pepsin- CLIA Kit

E-CL-M0539-24Tests 24 Tests
EUR 180
Description: Sandwich

Mouse PP -Pepsin- CLIA Kit

E-CL-M0539-48Tests 48 Tests
EUR 546
Description: Sandwich

Mouse PP -Pepsin- CLIA Kit

E-CL-M0539-96Tests 96 Tests
EUR 682
Description: Sandwich

Mouse PP -Pepsin- CLIA Kit

E-CL-M0539-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Mouse PP -Pepsin- CLIA Kit

E-CL-M0539-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Mouse PP(Pepsin) ELISA Kit

EM1304 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.938 ng/ml

Mouse Pepsin (PP) ELISA Kit

EKU11238-48T 48T
EUR 650.93

Mouse Pepsin (PP) ELISA Kit

EKU11238-5x96T 5x96T
EUR 4417.03

Mouse Pepsin (PP) ELISA Kit

EKU11238-96T 96T
EUR 929.9

Mouse Pepsin (PP) ELISA Kit

EKU10191-48T 48T
EUR 542.78

Mouse Pepsin (PP) ELISA Kit

EKU10191-5x96T 5x96T
EUR 3683.15

Mouse Pepsin (PP) ELISA Kit

EKU10191-96T 96T
EUR 775.4

Mouse Pepsin (PP) ELISA Kit

EKN52349-48T 48T
EUR 405.02

Mouse Pepsin (PP) ELISA Kit

EKN52349-5x96T 5x96T
EUR 2748.35

Mouse Pepsin (PP) ELISA Kit

EKN52349-96T 96T
EUR 578.6

Mouse Pepsin (PP) ELISA Kit

EKN51302-48T 48T
EUR 337.82

Mouse Pepsin (PP) ELISA Kit

EKN51302-5x96T 5x96T
EUR 2292.35

Mouse Pepsin (PP) ELISA Kit

EKN51302-96T 96T
EUR 482.6

Mouse Pepsin(PP)ELISA Kit        

GA-E0648MS-48T 48T
EUR 403.2

Mouse Pepsin(PP)ELISA Kit        

GA-E0648MS-96T 96T
EUR 640.8

Mouse Pepsin (PP) ELISA Kit

CEA632Mu-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Pepsin (PP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Pepsin (PP) ELISA Kit

CEA632Mu-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Pepsin (PP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Pepsin (PP) ELISA Kit

CEA632Mu-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Pepsin (PP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Pepsin (PP) ELISA Kit

CEA632Mu-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Pepsin (PP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Pepsin (PP) ELISA Kit

4-CEA632Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Mouse Pepsin (PP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse PP(Pepsin) ELISA Kit

RE2201M-48wells 48 wells
EUR 116.55

Mouse PP(Pepsin) ELISA Kit

RE2201M-96wells 96 wells
EUR 161.55

Mouse Pepsin(PP)ELISA Kit

QY-E21144 96T
EUR 433.2

Mouse Pepsin,PP ELISA Kit        

YLA0058MO-48T 48T Ask for price

Mouse Pepsin,PP ELISA Kit        

YLA0058MO-96T 96T Ask for price

Pepsin (PP) Polyclonal Antibody (Human), PE

4-PAA632Hu01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Pepsin (PP). This antibody is labeled with PE.

Pepsin (PP) Polyclonal Antibody (Human), APC

4-PAA632Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
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Description: A Rabbit polyclonal antibody against Human Pepsin (PP). This antibody is labeled with APC.

Pepsin (PP) Polyclonal Antibody (Human), Cy3

4-PAA632Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Human Pepsin (PP). This antibody is labeled with Cy3.

Pepsin (PP) Polyclonal Antibody (Human), HRP

4-PAA632Hu01-HRP
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Human Pepsin (PP). This antibody is labeled with HRP.

Pepsin (PP) Polyclonal Antibody (Human), FITC

4-PAA632Hu01-FITC
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Human Pepsin (PP). This antibody is labeled with FITC.

PPP1CA mouse monoclonal antibody, clone PP-1A, Purified

AM20663PU-N 100 µg Ask for price

Mouse Pepsin, PP GENLISA ELISA        

KLM0635 1 x 96 wells
EUR 341

Formulating monoclonal antibodies as powders for reconstitution at excessive focus utilizing spray-drying: Trehalose/amino acid combos as reconstitution time decreasing and stability enhancing formulations

 

 

To extend their stability, therapeutic (or monoclonal) antibodies (mAbs) are sometimes formulated as solids by utilizing quite a lot of drying methods, e.g. freeze-drying, spray-drying, or spray freeze-drying. The addition of excipients is required to protect stability of the protein in the course of the drying course of and subsequent storage of the ensuing strong type. The addition of low molecular weight excipients, similar to amino acids, to sugar based mostly spray- and freeze-dried formulations has been recommended to enhance the storage stability of proteins within the dried state.

 

On this examine sugars (sucrose, trehalose), amino acids (Gly, Ala, Professional, Ser, Val, Leu, Ile, Gln, His, Lys, Arg, Phe, Trp) and combos thereof have been investigated for his or her stabilizing impact throughout spray-drying and subsequent storage and for his or her reconstitution time decreasing impact.

 

Two IgG4 mAbs have been used as mannequin antibodies. From an preliminary screening examine, fundamental and small impartial amino acids, together with a sugar, similar to sucrose or trehalose, confirmed reconstitution time decreasing and stabilizing properties. Arg particularly displayed glorious reconstitution and stability enhancing properties. Furthermore, Arg was the one amino acid offering stabilizing properties akin to sucrose or trehalose.

 

Earlier work by the authors described a statistically substantiated comparability between the three fundamental amino acids in a sugar containing formulation, albeit restricted to a single focus degree [5]. Due to this fact, a follow-up design of experiments (DoE) examine was carried out to find out the optimum trehalose/amino acid content material required for an optimum protein stability and reconstitution time and to check the results of two fundamental amino acids, Lys and Arg, to these of two impartial amino acids, Gly and Professional. The performed DoE coated a variety of trehalose (30 – 120 mM) and amino acid (50 – 150 mM) concentrations.

 

The focus of trehalose was discovered to be the principle contributor to a discount in reconstitution time and a rise in stability. Right here we present that the addition of amino acids similar to Gly, Professional, and Lys doesn’t enhance stability nor does it scale back the reconstitution time. Of the examined amino acids, solely Arg confirmed a marked discount in reconstitution time and enchancment in stability in comparison with a trehalose.

 

Furthermore, the properties displayed by Arg might justify its software as the principle stabilizer in spray-dried mAb formulations, eliminating the necessity for a sugar matrix altogether. However the weight ratio of stabilizer to protein was discovered the issue exerting the strongest general affect on the formulation’s reconstitution time and stability. Extra particularly, adequate bodily stability and an appropriate reconstitution time might be obtained with a protein to stabilizer weight ratio of not less than 1:1.

 

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), HRP

4-MAA991Mi28-HRP
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  • 100ul
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  • 200ul
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Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with HRP.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), FITC

4-MAA991Mi28-FITC
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with FITC.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), APC-Cy7

4-MAA991Mi28-APC-Cy7
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with APC-Cy7.

Ghrelin (GHRL) Monoclonal Antibody (Human, Mouse, Rat, Dog), Biotinylated

4-MAA991Mi28-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human, Mouse, Rat, Dog Ghrelin (GHRL). This antibody is labeled with Biotin.

Monoclonal GHRL / Ghrelin Antibody (clone 2F4), Clone: 2F4

AMM04782G 0.05mg
EUR 633.6
Description: A Monoclonal antibody against Human GHRL / Ghrelin (clone 2F4). The antibodies are raised in Mouse and are from clone 2F4. This antibody is applicable in WB and IHC-P, E

Monoclonal GHRL / Ghrelin Antibody (clone 4B8), Clone: 4B8

AMM04783G 0.05mg
EUR 633.6
Description: A Monoclonal antibody against Human GHRL / Ghrelin (clone 4B8). The antibodies are raised in Mouse and are from clone 4B8. This antibody is applicable in WB and IHC-P, E

Rat Monoclonal anti-mouse Ghrelin

mAP-0439 50ug
EUR 400

Ghrelin (GHRL) Polyclonal Antibody (Mouse)

4-PAA991Mu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL)

Ghrelin (GHRL) Antibody

20-abx100169
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx129314
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx176583
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx176584
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ghrelin (GHRL) Antibody

20-abx176585
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  • 100 ug
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  • 1 mg
  • 200 ug
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Ghrelin (GHRL) Antibody

20-abx328383
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  • 100 ug
  • 50 ug

Ghrelin (GHRL) Antibody

abx100169-100l 100 µl
EUR 250

Ghrelin (GHRL) Antibody

abx100169-1ml 1 ml
EUR 675

Ghrelin (GHRL) Antibody

abx100169-200l 200 µl
EUR 312.5

Ghrelin (GHRL) Antibody

abx129314-100l 100 µl
EUR 262.5

Ghrelin (GHRL) Antibody

abx129314-1ml 1 ml
EUR 687.5

Ghrelin (GHRL) Antibody

abx129314-200l 200 µl
EUR 325

Ghrelin (GHRL) Antibody

abx176583-1096tests 10 × 96 tests
EUR 675

Ghrelin (GHRL) Antibody

abx176583-596tests 5 × 96 tests
EUR 312.5

Ghrelin (GHRL) Antibody

abx176583-96tests 96 tests
EUR 250

Ghrelin (GHRL) Antibody

abx176584-1096tests 10 × 96 tests
EUR 687.5

Ghrelin (GHRL) Antibody

abx176584-596tests 5 × 96 tests
EUR 325

Ghrelin (GHRL) Antibody

abx176584-96tests 96 tests
EUR 262.5

Ghrelin (GHRL) Antibody

abx176585-1096tests 10 × 96 tests
EUR 725

Ghrelin (GHRL) Antibody

abx176585-596tests 5 × 96 tests
EUR 337.5

Ghrelin (GHRL) Antibody

abx176585-96tests 96 tests
EUR 262.5

Ghrelin (GHRL) Antibody

abx132316-100tests 100 tests
EUR 287.5

Ghrelin (GHRL) Antibody

abx328383-100g 100 µg
EUR 250

Ghrelin (GHRL) Antibody

abx328383-50g 50 µg
EUR 187.5

Ghrelin (GHRL) Polyclonal Antibody (Mouse), PE

4-PAA991Mu01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with PE.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), APC

4-PAA991Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with APC.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), Cy3

4-PAA991Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with Cy3.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), HRP

4-PAA991Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with HRP.

Ghrelin (GHRL) Polyclonal Antibody (Mouse), FITC

4-PAA991Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with FITC.

Ghrelin Antibody / GHRL

F53880-0.05ML 0.05 ml
EUR 140.25
Description: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.

Ghrelin Antibody / GHRL

RQ6876 100ug
EUR 356.15
Description: This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.,Amino acids QRKESKKPPAKLQPR from the human protein were used as the immunogen for the Ghrelin antibody.,After reconstitution

Ghrelin (GHRL) Antibody (Biotin)

20-abx272533
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  • 100 ug
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  • 1 mg
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Ghrelin (GHRL) Antibody (Biotin)

abx272533-1ml 1 ml
EUR 737.5

Ghrelin (GHRL) Antibody (Biotin)

abx272533-200l 200 µl
EUR 337.5

Ghrelin (GHRL) Polyclonal Antibody (Mouse), Biotinylated

4-PAA991Mu01-Biotin
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with Biotin.

Monoclonal Anti-Human Ghrelin IgG # 3, aff pure

GHS13-M 100 ug
EUR 578.4

Rat Monoclonal anti-mouse Obestatin (Ghrelin prepropeptide)

mAP-0490 50ug
EUR 400

Ghrelin (GHRL) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA991Mu01-APC-Cy7
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Ghrelin (GHRL). This antibody is labeled with APC-Cy7.

Ghrelin (GHRL) Polyclonal Antibody

CAU31321-100ul 100ul
EUR 211.2

Ghrelin (GHRL) Polyclonal Antibody

CAU31321-200ul 200ul
EUR 263.8

Ghrelin (GHRL) Polyclonal Antibody

CAU31322-100ul 100ul
EUR 217.9

Ghrelin (GHRL) Polyclonal Antibody

CAU31322-200ul 200ul
EUR 272.2

Ghrelin (GHRL) Polyclonal Antibody

CAU31323-100ul 100ul
EUR 229.4

Ghrelin (GHRL) Polyclonal Antibody

CAU31323-200ul 200ul
EUR 287.3

Ghrelin (GHRL) Polyclonal Antibody

CAU26710-100ul 100ul
EUR 217.9

Ghrelin (GHRL) Polyclonal Antibody

CAU26710-200ul 200ul
EUR 272.2

Ghrelin (GHRL) Polyclonal Antibody

CAU26711-100ul 100ul
EUR 212.2

Ghrelin (GHRL) Polyclonal Antibody

CAU26711-200ul 200ul
EUR 265.4

Ghrl (untagged) - Mouse ghrelin (Ghrl), (10ug)

MC208061 10 µg Ask for price

Mouse Ghrelin (GHRL) Protein

20-abx167204
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  • 100 ug
  • 10 ug
  • 1 mg
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Mouse Ghrelin (GHRL) Protein

abx167204-100g 100 µg
EUR 512.5

Mouse Ghrelin (GHRL) Protein

abx167204-10g 10 µg
EUR 212.5

Mouse Ghrelin (GHRL) Protein

abx167204-50g 50 µg
EUR 362.5

Ghrl (Myc-DDK-tagged) - Mouse ghrelin (Ghrl)

MR212134 10 µg Ask for price

Ghrelin (GHRL) Polyclonal Antibody (Human)

4-PAA991Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Human Ghrelin (GHRL)

Mouse Ghrelin (GHRL) CLIA Kit

20-abx496443
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Ghrelin (GHRL) CLIA Kit

20-abx490342
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Ghrelin (GHRL) ELISA Kit

20-abx154080
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Ghrelin (GHRL) ELISA Kit

20-abx258875
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Mu 96T
EUR 432
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Mu-48T 48T
EUR 586.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

DLR-GHRL-Mu-96T 96T
EUR 762
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse ghrelin (GHRL) ELISA Kit

EKC36938-48T 48T
EUR 631.26

Mouse ghrelin (GHRL) ELISA Kit

EKC36938-5x96T 5x96T
EUR 4283.55

Mouse ghrelin (GHRL) ELISA Kit

EKC36938-96T 96T
EUR 901.8

Mouse ghrelin (GHRL) Elisa Kit

EK731893 96 Wells
EUR 0.83

Mouse Ghrelin (GHRL) ELISA Kit

EKU04362-48T 48T
EUR 514.08

Mouse Ghrelin (GHRL) ELISA Kit

EKU04362-5x96T 5x96T
EUR 3488.4

Mouse Ghrelin (GHRL) ELISA Kit

EKU04362-96T 96T
EUR 734.4

Mouse Ghrelin (GHRL) ELISA Kit

EKU10865-48T 48T
EUR 571.55

Mouse Ghrelin (GHRL) ELISA Kit

EKU10865-5x96T 5x96T
EUR 3878.38

Mouse Ghrelin (GHRL) ELISA Kit

EKU10865-96T 96T
EUR 816.5

Mouse Ghrelin (GHRL) ELISA Kit

EKU11130-48T 48T
EUR 617.68

Mouse Ghrelin (GHRL) ELISA Kit

EKU11130-5x96T 5x96T
EUR 4191.4

Mouse Ghrelin (GHRL) ELISA Kit

EKU11130-96T 96T
EUR 882.4

Mouse Ghrelin (GHRL) ELISA Kit

EKN45473-48T 48T
EUR 350.42

Mouse Ghrelin (GHRL) ELISA Kit

EKN45473-5x96T 5x96T
EUR 2377.85

Mouse Ghrelin (GHRL) ELISA Kit

EKN45473-96T 96T
EUR 500.6

Mouse Ghrelin (GHRL) ELISA Kit

DL-GHRL-Mu 96T
EUR 412
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

EK14245 96Т
EUR 768

Mouse Ghrelin (GHRL) ELISA Kit

CEA991Mu-10x96wellstestplate 10x96-wells test plate
EUR 5269.39
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

CEA991Mu-1x48wellstestplate 1x48-wells test plate
EUR 539.12
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

CEA991Mu-1x96wellstestplate 1x96-wells test plate
EUR 718.75
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

CEA991Mu-5x96wellstestplate 5x96-wells test plate
EUR 2874.38
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

4-CEA991Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse ghrelin (GHRL) ELISA Kit

CSB-E09817m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse ghrelin (GHRL) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse ghrelin (GHRL) ELISA Kit

1-CSB-E09817m
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse ghrelin (GHRL) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Ghrelin (GHRL) ELISA Kit

EKN51976-48T 48T
EUR 355.6

Mouse Ghrelin (GHRL) ELISA Kit

EKN51976-5x96T 5x96T
EUR 2413

Mouse Ghrelin (GHRL) ELISA Kit

EKN51976-96T 96T
EUR 508

Mouse Ghrelin (GHRL) ELISA Kit

EKN52241-48T 48T
EUR 384.3

Mouse Ghrelin (GHRL) ELISA Kit

EKN52241-5x96T 5x96T
EUR 2607.75

Mouse Ghrelin (GHRL) ELISA Kit

EKN52241-96T 96T
EUR 549

Mouse Ghrelin(GHRL) ELISA Kit

NSL1173m 96 Test
EUR 528

Mouse Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Mu-48T 48T
EUR 443.42
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Mu-48Tests 48 Tests
EUR 613.2

Mouse Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Mu-96T 96T
EUR 633.47
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

RDR-GHRL-Mu-96Tests 96 Tests
EUR 850.8

Mouse Ghrelin (GHRL) ELISA Kit

RD-GHRL-Mu-48T 48T
EUR 422.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

RD-GHRL-Mu-48Tests 48 Tests
EUR 586.8

Mouse Ghrelin (GHRL) ELISA Kit

RD-GHRL-Mu-96T 96T
EUR 603.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

RD-GHRL-Mu-96Tests 96 Tests
EUR 812.4

Mouse Ghrelin (GHRL) ELISA Kit

SEA991Mu-10x96wellstestplate 10x96-wells test plate
EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

SEA991Mu-1x48wellstestplate 1x48-wells test plate
EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

SEA991Mu-1x96wellstestplate 1x96-wells test plate
EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

SEA991Mu-5x96wellstestplate 5x96-wells test plate
EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ghrelin (GHRL) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Ghrelin (GHRL) ELISA Kit

4-SEA991Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Ghrelin (GHRL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Ghrelin(GHRL) ELISA Kit

YLA1336MO-48T 48T Ask for price

Mouse Ghrelin(GHRL) ELISA Kit

YLA1336MO-96T 96T Ask for price

Mouse Ghrelin (GHRL) ELISA Kit

abx258875-1mg 1 mg
EUR 6187.5

Mouse Ghrelin (GHRL) ELISA Kit

abx258875-20g 20 µg
EUR 3275

Mouse Ghrelin (GHRL) ELISA Kit

abx258875-5g 5 µg
EUR 687.5

Mouse Ghrelin (GHRL) Protein (BSA)

20-abx651193
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Ghrelin (GHRL) Protein (OVA)

20-abx651194
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Ghrelin (GHRL) Peptide (BSA)

abx651193-5mg 5 mg
EUR 500

Mouse Ghrelin (GHRL) Peptide (OVA)

abx651194-5mg 5 mg
EUR 500

Mouse Ghrelin, GHRL)GENLISA ELISA

KLM1133 1 x 96 wells
EUR 341

Ghrelin (GHRL) Polyclonal Antibody (Human), PE

4-PAA991Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ghrelin (GHRL). This antibody is labeled with PE.

Ghrelin (GHRL) Polyclonal Antibody (Human), APC

4-PAA991Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ghrelin (GHRL). This antibody is labeled with APC.

Ghrelin (GHRL) Polyclonal Antibody (Human), Cy3

4-PAA991Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ghrelin (GHRL). This antibody is labeled with Cy3.

Ghrelin (GHRL) Polyclonal Antibody (Human), HRP

4-PAA991Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ghrelin (GHRL). This antibody is labeled with HRP.

MTLRP (GHRL) mouse monoclonal antibody, clone Ghr5

2GH1-Ghr5 1 mg Ask for price

MTLRP (GHRL) mouse monoclonal antibody, clone Ghr6

2GH1-Ghr6 1 mg Ask for price

Ghrelin (GHRL) Polyclonal Antibody (Human), FITC

4-PAA991Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ghrelin (GHRL). This antibody is labeled with FITC.

Ghrl (untagged) - Mouse ghrelin (Ghrl), transcript variant 4

MC225530 10 µg Ask for price

Ghrl (untagged) - Mouse ghrelin (Ghrl), transcript variant 3

MC225564 10 µg Ask for price

Ghrl (untagged) - Mouse ghrelin (Ghrl), transcript variant 2

MC225715 10 µg Ask for price

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