Primary prevention of sickle cell disease
Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective
- For couples with sickle cell trait (SCT) who are at risk for having a child with sickle cell disease (SCD), cost is a barrier to using in vitro fertilization (IVF) with preimplantation genetic testing for monogenic diseases (PGT-M) and insurance coverage is not universal.
- The objective of this study was to evaluate the cost-effectiveness of IVF+PGT-M for couples who both carry SCT and wish to avoid SCD in a child compared to natural conception with the possible birth of a child with SCD, and the associated lifetime medical costs and lost income. A cost-effectiveness analysis was performed with a decision analytic model. Sensitivity analyses, including Monte Carlo Simulations, assessed the impact of changes in input parameters on the incremental cost-effectiveness ratio (ICER).
- Probabilities and cost estimates were derived from the published literature. Effectiveness was measured in life years (LY) gained. The ICER was calculated to determine the cost-effectiveness of the IVF+PGT-M intervention. Compared to natural conception, IVF+PGT-M had an effectiveness gain of 30 LY, an additional cost of $572,392.68 per individual conceived, and an ICER of $19,319 per LY gained.
- The ICER is lower than a conservative, preset willingness to pay (WTP) threshold of $50,000 per LY gained. Monte Carlo Simulations demonstrated that, in 91% of iterations, IVF+PGT-M was cost-effective at the WTP of $50,000. IVF+PGT-M is a cost-effective strategy to avoid conceiving a child with SCD and broader insurance coverage is warranted. This article is protected by copyright. All rights reserved.
 Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 349 |
 Anti-IL-6 Antibody |
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| A00102-1 | BosterBio | 100ug | EUR 432 |
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Description: Rabbit Polyclonal IL-6 Antibody. Validated in Neu, IHC, WB and tested in Human. |
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 Anti-IL-31 Antibody |
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| A08339-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-IL-17B Antibody |
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| A10846-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for IL-17B Antibody (IL17B) detection.tested for IHC in Human, Rat. |
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) Anti-PKA R2 (6A9) |
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| YF-MA10721 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to PKA R2 |
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) Anti-PKA R2 (3C7) |
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| YF-MA14876 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to PKA R2 |
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 antibody) Anti-MonoMethylH3R2me1-(R2) antibody |
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| STJ24010 | St John's Laboratory | 100 µl | EUR 393 |
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Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. |
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 Anti-GABAB R2 antibody |
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| STJ96379 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to GABAB R2. |
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 Anti-TNF-R2 antibody |
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| STJ96053 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to TNF-R2. |
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 Anti-IL-2/IL2 Antibody |
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| A00387-1 | BosterBio | 100ug/vial | EUR 294 |
 Anti-IL-8 Monoclonal Antibody |
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| A00423-1 | BosterBio | 100ul | EUR 397 |
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Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat. |
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 Anti-IL-22/IL22 Antibody |
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| A00963-1 | BosterBio | 100ug/vial | EUR 294 |
 Anti-IL-3R beta Antibody |
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| A02219-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for IL-3R beta Antibody (CSF2RB) detection.tested for WB in Human, Mouse, Rat. |
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 Anti-IL-6 Monoclonal Antibody |
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| M00102-1 | BosterBio | 100ug | EUR 455 |
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Description: Mouse Monoclonal IL-6 Antibody. Validated in Flow Cytometry, WB and tested in Human. |
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 Anti-IL-17A Monoclonal Antibody |
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| M00421-1 | BosterBio | 100ug | EUR 455 |
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Description: Mouse Monoclonal IL-17A Antibody. Validated in WB and tested in Human. |
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 Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5 |
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| CABT-L4486-1mg | Creative Diagnostics | 1 mg | EUR 897 |
Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5 |
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| CABT-L4486-5mg | Creative Diagnostics | 5 mg | EUR 2405 |
 IL-1 β |
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| E13-003-1 | EnoGene | 10μg | EUR 213 |
 IL-1 α |
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| E13-029-1 | EnoGene | 10μg | EUR 213 |
 Anti-Human IL-17F Biotin Conjugated Monoclonal Antibody |
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| B02062-1 | BosterBio | 100ug | EUR 432 |
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Description: Mouse Monoclonal Human IL-17F Biotin Conjugated Antibody. Validated in IHC, WB and tested in Human. |
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 R2 Purified) Anti-GABA(B) R2 Purified |
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| 11-551-C100 | ExBio | 0.1 mg | EUR 204 |
 Anti-IL-32A Antibody Peroxidase Conjugated |
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| A03286-1 | BosterBio | 100ug | EUR 455 |
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Description: Rabbit Polyclonal IL-32A Antibody Peroxidase Conjugated. Validated in WB and tested in Human. |
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 IL-1 beta, rat recombinant |
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| P1019-1 | ApexBio | 1 mg | EUR 7288 |
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Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells. Both IL-1? and IL-1? bind to the same receptor and have similar biological properties. |
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 Notoginsenoside R2 |
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| TN028181 | ChemNorm | 20mg | Ask for price |
 Stipuleanoside R2 |
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| TBZ1475 | ChemNorm | unit | Ask for price |
Notoginsenoside R2 |
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| HY-N0909 | MedChemExpress | 10mg | EUR 463 |
 IL-1beta, human recombinant |
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| P1018-1 | ApexBio | 1 mg | EUR 5061 |
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Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells |
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 IL-2, human recombinant |
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| P1020-1 | ApexBio | 1 mg | EUR 1156 |
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Description: Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes and is produced by activated CD4+ and CD8+ T cells, gamma ? T cells, B cells, dendritic cells and eosinophils. IL-2 plays a critical role in immune responses against pathogenic infection |
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 IL-3, human recombinant |
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| P1021-1 | ApexBio | 1 mg | EUR 4017 |
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Description: Interleukin 3 (IL-3) is a pleiotropic cytokine produced by activated T cells, mast cells and eosinophils, and stimulates the proliferation and differentiation of pluripotent hematopoietic stem cells, and committed progenitor cells of the megakaryocyte |
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 IL-7, human recombinant |
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| P1024-1 | ApexBio | 1 mg | EUR 6940 |
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Description: Interleukin-7 (IL-7) is a potent lymphoid cell growth factor produced by bone marrow and thymic stromal cells, spleen cells and keratinocytes. IL7 stimulates the proliferation of Pre-B, Pro-B and early T cells. |
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 AssayMax ELISA Kit) Human Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit |
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| EI2200-1 | AssayPro | 96 Well Plate | EUR 477 |
 AssayMax ELISA Kit) Human Interleukin-1-alpha (IL-1-alpha) AssayMax ELISA Kit |
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| EI2301-1 | AssayPro | 96 Well Plate | EUR 477 |
 Recombinant Rat IL-1 Beta Protein |
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| PROTQ63264-1 | BosterBio | 10ug | EUR 317 |
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Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues. |
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 Canine IL-1 beta Recombinant Protein |
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| R00101-1 | BosterBio | 5ug/vial | EUR 259 |
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Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Canine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast. |
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 Canine IL-1 alpha Recombinant Protein |
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| R01144-1 | BosterBio | 5ug/vial | EUR 259 |
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Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Canine IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast. |
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 Antibody) Anti-Phospho-GABAB R2 (Ser783) Antibody |
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| P03830 | BosterBio | 100ul | EUR 398 |
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Description: Rabbit Polyclonal Phospho-GABAB R2 (Ser783) Antibody. Validated in IF, WB and tested in Mouse, Rat. |
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 Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 280 |
 Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
 IL-1-alpha Interleukin-1 alpha Human Recombinant Protein, His Tag |
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| PROTP01583-1 | BosterBio | Regular: 20ug | EUR 317 |
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Description: IL-1A Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids fragment (113-271) with an amino-terminal hexahistidine tag and having a total molecular mass of 22.5kDa. ;The Interleukin-1 alpha His-tag is purified by proprietary chromatographic techniques. |
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 IL-1-beta Interleukin-1 betaHuman Recombinant Protein |
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| PROTP01584-1 | BosterBio | Regular: 10ug | EUR 317 |
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Description: Interleukin-1 beta Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton.;The IL-1b is purified by proprietary chromatographic techniques. |
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 Recombinant Human IL-24 Protein |
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| PROTQ13007-1 | BosterBio | 20ug | EUR 317 |
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Description: IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag. |
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 Recombinant Human IL-31 Protein |
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| PROTQ6EBC2-1 | BosterBio | 10ug | EUR 317 |
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Description: Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues. |
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 Recombinant Human IL-17D Protein |
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| PROTQ8TAD2-1 | BosterBio | 25ug | EUR 317 |
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Description: IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8, and GM-CSF and inhibits hemopoiesis of myeloid progenitor cells in colony forming assays. Recombinant human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains. |
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 Recombinant Human IL-22 Protein |
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| PROTQ9GZX6-1 | BosterBio | 10ug | EUR 317 |
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Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains. |
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 Recombinant Human IL-17E Protein |
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| PROTQ9H293-1 | BosterBio | 25ug | EUR 317 |
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Description: IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 145 amino acid polypeptide chains. |
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 Recombinant Human IL-20 Protein |
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| PROTQ9NYY1-1 | BosterBio | 10ug | EUR 317 |
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Description: IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-α and type II IL-20R-β. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains. |
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 Recombinant Human IL-19 Protein |
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| PROTQ9UHD0-1 | BosterBio | 10ug | EUR 317 |
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Description: IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-α and induces apoptosis through TNF-α. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer. |
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 Recombinant Human IL-12 Protein |
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| PROTP29459-1 | BosterBio | 10ug | EUR 317 |
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Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues). |
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 IL-10, human recombinant protein |
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| P1028-1 | ApexBio | 1 mg | EUR 6731 |
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Description: Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the synthesis of proinflammatory cytokines such as IL-1 and TNF-? and proliferation of T cells |
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 IL-15, human recombinant protein |
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| P1029-1 | ApexBio | 1 mg | EUR 5339 |
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Description: Interleukin 15 (IL-15) is an immunomodulating cytokine mainly produced by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells and stimulates the proliferation of T lymphocytes. |
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 IL-17A, human recombinant protein |
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| P1030-1 | ApexBio | 1 mg | EUR 4156 |
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Description: Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by Th17 cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases and stimulates the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as the production of nitric oxide (NO). |
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 IL-18, human recombinant protein |
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| P1032-.1 | ApexBio | 100 µg | EUR 780 |
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Description: Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures. |
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IL-18, human recombinant protein |
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| P1032-1 | ApexBio | 1 mg | EUR 5061 |
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Description: Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures. |
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 IL-21, human recombinant protein |
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| P1033-1 | ApexBio | 1 mg | EUR 6522 |
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Description: Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. IL-21 induces the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells, apoptotic effects in naïve B-cells. |
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 Protein) Recombinant Murine IL-17 (IL-17A) Protein |
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| PROTQ62386-1 | BosterBio | 25ug | EUR 317 |
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Description: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains. |
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 TNF-R2 Antibody |
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| AF0364 | Affbiotech | 200ul | EUR 304 |
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Description: TNF-R2 antibody detects endogenous levels of total TNF-R2. |
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TNF-R2 Antibody |
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| AF0365 | Affbiotech | 200ul | EUR 304 |
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Description: TNF-R2 antibody detects endogenous levels of total TNF-R2. |
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 TNF- R2 Antibody |
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| ABF0364 | Lifescience Market | 100 ug | EUR 438 |
TNF- R2 Antibody |
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| ABF0365 | Lifescience Market | 100 ug | EUR 438 |
 ApoE R2, CF |
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| PR15062CF | Neuromics | 50 ug | EUR 461 |
 R-Notoginsenoside R2 |
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| N2244-20 | ApexBio | 20 mg | EUR 572 |
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Description: Extracted from Panax Notoginseng dried roots;Store the product in sealed, cool and dry condition |
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, human recombinant) IL-8 (77 a.a.), human recombinant |
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| P1026-1 | ApexBio | 1 mg | EUR 4226 |
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Description: Interleukin-8 (IL-8) is a proinflammatory CXC chemokine produced by macrophages, epithelial cells. IL-8 is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies |
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, R2-Subunit antibody) Anti-GABAB Receptor (Ser783), R2-Subunit antibody |
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| STJ120094 | St John's Laboratory | 100 µl | EUR 526 |
 AssayMax ELISA Kit) Mouse Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit |
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| EMI2200-1 | AssayPro | 96 Well Plate | EUR 477 |
 Human Recombinant Protein (CXCL8)) IL-8 Interleukin-8 (1-77 a.a) Human Recombinant Protein (CXCL8) |
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| PROTP10145-1 | BosterBio | Regular: 25ug | EUR 317 |
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Description: Interleukin-8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8904 Dalton. ;The IL-8 is purified by proprietary chromatographic techniques. |
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 IL-1RA Interleukin-1 Receptor Antagonist Human Recombinant Protein, His Tag |
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| PROTP18510-1 | BosterBio | Regular: 50ug | EUR 682 |
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Description: IL1Ra Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.63kDa with an amino-terminal hexahistidine tag. ;The IL-1Ra His is purified by proprietary chromatographic techniques. |
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 Anti-IL 1 alpha antibody |
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| PAab04208 | Lifescience Market | 100 ug | EUR 386 |
 Anti-IL-1 beta Antibody |
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| A00101-2 | BosterBio | 1mg | EUR 1232 |
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Description: Rabbit Polyclonal IL-1 beta Antibody. Validated in IP, IHC, WB and tested in Human. |
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 Anti-IL-1 Alpha Antibody |
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| A01144 | BosterBio | 1mg | EUR 1232 |
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Description: Rabbit Polyclonal IL-1 Alpha Antibody. Validated in WB and tested in Human. |
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 Anti-IL-1 RII antibody |
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| STJ16100664 | St John's Laboratory | 100 µg | EUR 742 |
 Anti-IL-1 beta antibody |
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| STJ73078 | St John's Laboratory | 100 µg | EUR 359 |
 anti- IL 1 alpha antibody |
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| FNab04208 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against IL 1 alpha |
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 IL-2 |
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| E13-013-1 | EnoGene | 10μg | EUR 161 |
 IL-4 |
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| E13-015-1 | EnoGene | 10μg | EUR 161 |
 IL-6 |
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| E13-016-1 | EnoGene | 10μg | EUR 161 |
 IL-1-alpha Interleukin-1 alpha Mouse Recombinant Protein, His Tag |
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| PROTP01582-1 | BosterBio | Regular: 20ug | EUR 317 |
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Description: IL 1 alpha Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.4kDa.;IL 1 alpha is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
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 IL-1-beta Interleukin-1 beta Mouse Recombinant Protein, His Tag |
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| PROTP10749-1 | BosterBio | Regular: 25ug | EUR 317 |
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Description: Interleukin-1 beta Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 189 amino acids and having a molecular mass of 21 kDa. ;The IL-1b is fused to His-Tag and purified by proprietary chromatographic techniques. |
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 IL-1-alpha Interleukin-1 alpha Rat Recombinant Protein, His Tag |
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| PROTP16598-1 | BosterBio | Regular: 20ug | EUR 317 |
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Description: IL 1 alpha Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.2kDa. |
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In vitro fertilisation with preimplantation genetictesting: the need for expanded insurance coverage
Technological advances in genetic testing have enabled prospective parents to learn about their risk of passing a genetic condition to their future children.
One option for those who want to ensure that their biological children do not inherit a genetic condition is to create embryos through in vitro fertilisation (IVF) and use a technique called preimplantation genetic testing (PGT) to screen embryos for genetic abnormalities before implantation.
Unfortunately, due to its high cost, IVF-with-PGT is out of reach for the vast majority of Americans. This article addresses an issue that has been underexplored in the medical ethics literature: the lack of insurance coverage for IVF-with-PGT.Within the US system, a key concept in insurance is that of medically necessary care, which broadly consists of diagnostic services and treatment services. In this article, I argue that IVF-with-PGT could be classified as either a diagnostic service or as a treatment service.
To make this case, I show that IVF-with-PGT is similar to other types of services that are often covered by US insurance providers. In light of these similarities, I argue that the current system is inconsistent with respect to what is-and is not-covered by insurance. To promote consistency and fairness in coverage, like cases should be treated alike-starting with greater coverage for IVF-with-PGT.
Lack of familiarity with genetictesting among patients in Ireland with Cancer
Background: Cancer gene panel testing is available in Ireland. The need for a clear strategy to deal with patient information generated from tumour genomic testing is recognised as a challenge in the National Cancer Strategy. However, the public’s attitude and opinions regarding these results is not known in Ireland.
Aims: This prospective questionnaire study assessed the knowledge and opinions of patients in a national oncology centre, surrounding cancer gene panel testing.
Methods: An anonymised modified validated questionnaire was completed by volunteering patients in the medical oncology department. It comprised 14 questions which assessed patient’s familiarity, intention, benefits and concerns associated with tumour genetic testing using a four-point Likert scale. Patients recorded their primary cancer diagnosis and family cancer history.
Results: Eighty-four patients completed the questionnaire with 77 (92%) patients declaring their primary cancer diagnosis. The median age was 56 (range 26 to 83) years. Overall, 42% (n = 35) of oncology patients were familiar/somewhat familiar with testing and 90% (n = 76) stated they would avail of genetic testing if available. Patients with breast cancer were no more likely to avail of genetic testing when compared with the non-breast cancer cohort (n = 21 vs. 56, p = 0.58) though they identified concerns with potential discrimination.
Conclusion: This is the first prospective Irish study to assess opinions surrounding cancer gene results. Addressing patient’s lack of information as regards genetic testing is the first step in establishing a national cancer genetics testing programme in Ireland.
 1730 8 SNAP-SEAL 8 OZ |
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| 1730-8 | CORNING | 100/pk | EUR 74 |
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Description: Disposable Plastic; Plastic Containers |
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 mAb mouse anti-human IL-8 |
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| CT264 | U-CyTech | 0.5 mg | EUR 260 |
 IL-8 |
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| E5-00004 | EnoGene | 1mg | EUR 960 |
Anti-IL-8 Monoclonal Antibody |
|||
| A00423-1 | BosterBio | 100ul | EUR 397 |
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Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat. |
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 Individual Reaction Mix 8 |
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| G065-8 | ABM | 200 reactions | EUR 167 |
 Swine IL-6 Recombinant Protein |
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| R00102-8 | BosterBio | 5ug/vial | EUR 259 |
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Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Swine IL-6 Recombinant Protein is purified interleukin-6 produced in yeast. |
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 Swine IL-4 Recombinant Protein |
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| R00230-8 | BosterBio | 5ug/vial | EUR 259 |
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Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Swine IL-4 Recombinant Protein is purified interleukin-4 produced in yeast. |
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 Rabbit IL-2 Recombinant Protein |
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| R00387-8 | BosterBio | 5ug/vial | EUR 259 |
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Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Rabbit IL-2 Recombinant Protein is purified interleukin-2 produced in yeast. |
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 Swine IL-17A Recombinant Protein |
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| R00421-8 | BosterBio | 5ug/vial | EUR 259 |
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Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Swine IL-17A Recombinant Protein is purified interleukin-17A produced in yeast. |
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Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 349 |
 Antibody) Human Interleukin-8 (IL-8) Antibody |
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| 13102-05011 | AssayPro | 150 ug | EUR 207 |
 Ovine IL-1 beta Recombinant Protein |
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| R00101-8 | BosterBio | 5ug/vial | EUR 259 |
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Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Ovine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast. |
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 Recombinant Human IL-8 |
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| SJB05-01 | Amyotop | 25µg/vial | EUR 285 |
 Human IL-8 Protein |
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| abx060803-25ug | Abbexa | 25 ug | EUR 537 |
Human IL-8 Protein |
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| abx060804-25ug | Abbexa | 25 ug | EUR 537 |
 Human IL-8 Antibody |
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| 33486-05111 | AssayPro | 150 ug | EUR 261 |
 IL-8/CXCL8, Human |
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| HY-P7224 | MedChemExpress | 50ug | EUR 497 |
Recombinant Human IL-8 |
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| P0180 | FN Test | 100ug | EUR 522.36 |
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Description: Recombinant Human protein for IL-8 |
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 antibody) Anti-bovine IL-8 (CXCL8) antibody |
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| STJ15100008 | St John's Laboratory | 250 µg | EUR 336 |
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Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot. |
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Anti-bovine IL-8 (CXCL8) antibody |
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| STJ15100009 | St John's Laboratory | 250 µg | EUR 336 |
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Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA. |
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 IL-8 Antibody |
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| BF0238 | Affbiotech | 200ul | EUR 376 |
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Description: IL-8 antibody detects endogenous levels of total IL-8. |
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IL-8 Antibody |
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| 5149-100 | Biovision | EUR 338 | |
 IL-8 Inhibitor |
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| 5-01378 | CHI Scientific | 4 x 5mg | Ask for price |
 CXCL8/IL-8 |
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| GT15156 | Neuromics | 100 ug | EUR 526 |
CXCL8/IL-8 |
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| E21-C97 | EnoGene | 10ug | EUR 343 |
IL-8 Inhibitor |
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| H-2268.0001 | Bachem | 1.0mg | EUR 167 |
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Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net |
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IL-8 Inhibitor |
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| H-2268.0005 | Bachem | 5.0mg | EUR 576 |
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Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net |
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IL-8 Inhibitor |
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| H-2268.0025 | Bachem | 25.0mg | EUR 2207 |
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Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net |
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) Bovine(IL-8) |
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| QY-E60063 | Qayee Biotechnology | 96T | EUR 426 |
 IL-8, Interleukin-8, monkey |
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| RC222-19 | Bio Basic | 5ug | EUR 104.38 |
 ELISA Kit) Human Interleukin-8 (IL-8) ELISA Kit |
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| LF-EK60006 | Abfrontier | 1×96T | EUR 790 |
 Human Interleukin 8, IL-8 ELISA KIT |
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| CSB-E04641h-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
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Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Interleukin 8, IL-8 ELISA KIT |
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| 1-CSB-E04641h | Cusabio |
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Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid(CSF), tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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 Human Interleukin 8,IL-8 ELISA KIT |
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| 201-12-0090 | SunredBio | 96 tests | EUR 440 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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 CLIA Kit) Human Interleukin 8 (IL-8) CLIA Kit |
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| abx195916-96tests | Abbexa | 96 tests | EUR 825 |
ELISA Kit) Human Interleukin 8(IL-8)ELISA Kit |
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| GA-E0129HM-48T | GenAsia Biotech | 48T | EUR 289 |
Human Interleukin 8(IL-8)ELISA Kit |
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| GA-E0129HM-96T | GenAsia Biotech | 96T | EUR 466 |
 ELISA Kit) Human IL-8(Interleukin 8) ELISA Kit |
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| EH0205 | FN Test | 96T | EUR 476.25 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
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Human Interleukin 8(IL-8)ELISA Kit |
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| QY-E04259 | Qayee Biotechnology | 96T | EUR 361 |
 IL-8 ELISA KIT|Human |
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| EF003990 | Lifescience Market | 96 Tests | EUR 689 |
 Human IL-8 ELISA kit |
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| LF-EK50165 | Abfrontier | 1×96T | EUR 648 |
 ELISA Kit) IL-8 (Human) ELISA Kit |
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| K4169-100 | Biovision | EUR 729 | |
 Recombinant Human IL-8 Protein |
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| RP00052 | Abclonal | 5 μg | EUR 149 |
 IL-8/CXCL8, 72a.a., Human |
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| HY-P7380 | MedChemExpress | 50ug | EUR 497 |
 human IL-8 His tag |
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| E410A07-100 | EnoGene | 100μg | EUR 960 |
 Human IL-8 ELISA Kit |
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| EHI0063 | Abclonal | 96Tests | EUR 521 |
Human IL-8 ELISA kit |
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| CT212A | U-CyTech | 5-plate | EUR 462 |
) rec Endothelial IL-8 (human) |
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| H-3742.0010 | Bachem | 10.0µg | EUR 284 |
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Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9] |
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rec Endothelial IL-8 (human) |
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| H-3742.0050 | Bachem | 50.0µg | EUR 973 |
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Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9] |
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) rec Monocyte IL-8 (human) |
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| H-9625.0005 | Bachem | 5.0µg | EUR 162 |
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Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8] |
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rec Monocyte IL-8 (human) |
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| H-9625.0025 | Bachem | 25.0µg | EUR 381 |
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Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8] |
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 ELISA Kit) Bovine Cytokines IL-8(Cytokines IL-8) ELISA Kit |
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| QY-E60102 | Qayee Biotechnology | 96T | EUR 426 |
 IL-8, CXCL8, Interleukin-8, canine |
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| RC242-19 | Bio Basic | 5ug | EUR 104.38 |
 IL-8, CXCL8, Interleukin-8, porcine |
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| RC282-19 | Bio Basic | 5ug | EUR 104.38 |
) Guinea pig IL-8(Interleukin 8) |
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| EGP0055 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Guinea pig;Sensitivity: 9.375pg/ml |
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 ELISA) Horse Interleukin 8 (IL-8) ELISA |
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| QY-E120050 | Qayee Biotechnology | 96T | EUR 478 |
) Recombinant Human Interleukin-8/IL-8 (C-6His) |
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| CC97-10ug | Novoprotein | 10ug | EUR 146 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
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Recombinant Human Interleukin-8/IL-8 (C-6His) |
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| CC97-1mg | Novoprotein | 1mg | EUR 2283 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
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Recombinant Human Interleukin-8/IL-8 (C-6His) |
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| CC97-500ug | Novoprotein | 500ug | EUR 1613 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
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Recombinant Human Interleukin-8/IL-8 (C-6His) |
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| CC97-50ug | Novoprotein | 50ug | EUR 339 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
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) Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99) |
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| C035-10ug | Novoprotein | 10ug | EUR 151 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99) |
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| C035-1mg | Novoprotein | 1mg | EUR 1836 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99) |
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| C035-500ug | Novoprotein | 500ug | EUR 1298 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99) |
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| C035-50ug | Novoprotein | 50ug | EUR 354 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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) Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99) |
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| C037-10ug | Novoprotein | 10ug | EUR 151 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99) |
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| C037-1mg | Novoprotein | 1mg | EUR 1836 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99) |
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| C037-500ug | Novoprotein | 500ug | EUR 1298 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99) |
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| C037-50ug | Novoprotein | 50ug | EUR 344 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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 Antibody (Biotin Conjugate)) Human Interleukin-8 (IL-8) Antibody (Biotin Conjugate) |
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| 13102-05021 | AssayPro | 150 ug | EUR 261 |
 AssayMax ELISA Kit) Human Interleukin-8 (IL-8) AssayMax ELISA Kit |
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| EI1008-1 | AssayPro | 96 Well Plate | EUR 477 |
) ELISA kit for Human IL-8 (Interleukin 8) |
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| E-EL-H0048 | Elabscience Biotech | 1 plate of 96 wells | EUR 377 |
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Description: A sandwich ELISA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant |
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, human) IL-8, CXCL8, Interleukin-8 (72 a.a.), human |
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| RC212-19A | Bio Basic | 5ug | EUR 104.38 |
, human) IL-8, CXCL8, Interleukin-8 (77 a.a.), human |
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| RC212-19B | Bio Basic | 5ug | EUR 104.38 |
) CLIA kit for Human IL-8 (Interleukin 8) |
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| E-CL-H0048 | Elabscience Biotech | 1 plate of 96 wells | EUR 584 |
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Description: A sandwich CLIA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant |
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 ELISA kit for Human Interleukin 8,IL-8 |
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| EK0240 | SAB | 96 tests | EUR 603 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human Interleukin 8,IL-8 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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 IL-8 Blocking Peptide |
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| BF0238-BP | Affbiotech | 1mg | EUR 195 |
 IL-8 Polyclonal Antibody |
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| ABP51621-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8 |
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IL-8 Polyclonal Antibody |
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| ABP51621-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8 |
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IL-8 Polyclonal Antibody |
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| ABP51621-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8 |
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IL-8 Polyclonal Antibody |
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| ABP52884-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8 |
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IL-8 Polyclonal Antibody |
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| ABP52884-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8 |
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IL-8 Polyclonal Antibody |
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| ABP52884-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8 |
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IL-8 Polyclonal Antibody |
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| ABP54886-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8 |
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IL-8 Polyclonal Antibody |
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| ABP54886-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8 |
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IL-8 Polyclonal Antibody |
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| ABP54886-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8 |
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 Polyclonal IL-8 Antibody |
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| APR00274G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-8 . This antibody is tested and proven to work in the following applications: |
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 CXCR1/IL-8 RA |
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| MO15072 | Neuromics | 500 ug | EUR 910 |
 CXCR2/IL-8 RB |
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| MO15073 | Neuromics | 100 ug | EUR 474 |
CXCR2/IL-8 RB |
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| MO15084 | Neuromics | 100 ug | EUR 474 |
IL-8 Polyclonal Antibody |
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| ES3883-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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IL-8 Polyclonal Antibody |
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| ES3883-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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IL-8 Polyclonal Antibody |
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| ES2620-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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