Primary prevention of sickle cell disease

Ivan September 9, 2020 0 Comments
myasthenickids

Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective

  • For couples with sickle cell trait (SCT) who are at risk for having a child with sickle cell disease (SCD), cost is a barrier to using in vitro fertilization (IVF) with preimplantation genetic testing for monogenic diseases (PGT-M) and insurance coverage is not universal.
  • The objective of this study was to evaluate the cost-effectiveness of IVF+PGT-M for couples who both carry SCT and wish to avoid SCD in a child compared to natural conception with the possible birth of a child with SCD, and the associated lifetime medical costs and lost income. A cost-effectiveness analysis was performed with a decision analytic model. Sensitivity analyses, including Monte Carlo Simulations, assessed the impact of changes in input parameters on the incremental cost-effectiveness ratio (ICER).
  • Probabilities and cost estimates were derived from the published literature. Effectiveness was measured in life years (LY) gained. The ICER was calculated to determine the cost-effectiveness of the IVF+PGT-M intervention. Compared to natural conception, IVF+PGT-M had an effectiveness gain of 30 LY, an additional cost of $572,392.68 per individual conceived, and an ICER of $19,319 per LY gained.
  • The ICER is lower than a conservative, preset willingness to pay (WTP) threshold of $50,000 per LY gained. Monte Carlo Simulations demonstrated that, in 91% of iterations, IVF+PGT-M was cost-effective at the WTP of $50,000. IVF+PGT-M is a cost-effective strategy to avoid conceiving a child with SCD and broader insurance coverage is warranted. This article is protected by copyright. All rights reserved.
myasthenickids
myasthenickids

IL-1 R2 (Human) LumiAb ELISA Kit
MBS9510883-5x96StripWells 5x96-Strip-Wells
EUR 2225

IL-1 R2 (Human) LumiAb ELISA Kit
MBS9510883-96StripWells 96-Strip-Wells
EUR 500

IL-1 R2 (Human) OmniKine ELISA Kit
MBS9501955-1x96Wells 1x96Wells
EUR 500

IL-1 R2 (Human) OmniKine ELISA Kit
MBS9501955-5x96Wells 5x96Wells
EUR 2300

IL-1 R2 (Human) Sandwich ELISA Kit
OK-0229 1Kit
EUR 280
Description: IL-1 R2 (Human) Colorimetric Sandwich ELISA Kit

IL-1 R2 ELISA Kit (Human) : 96 Wells (OKAG00129)
OKAG00129 96 Wells
EUR 715.2
Description: Description of target: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 32 pg/mL

IL 1 R2 Recombinant Protein
96-436 0.1 mg
EUR 619.8
Description: Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Mouse Anti Human IL-1 beta
MBS140161-05mg 0.5mg
EUR 440

Mouse Anti Human IL-1 beta
MBS140161-1mg 1mg
EUR 600

Mouse Anti Human IL-1 beta
MBS140161-5x1mg 5x1mg
EUR 2375

Recombinant Mouse IL-1 R2/IL-1 RII Protein
RP00726 10μg
EUR 138.16

Recombinant Mouse IL-1 R2/IL-1 RII Protein
RP00729 10μg
EUR 138.16

Anti‐Human IL‐17A
E2790213 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Anti Human IL-1 beta FITC
MBS140163-05mg 0.5mg
EUR 440

Mouse Anti Human IL-1 beta FITC
MBS140163-1mg 1mg
EUR 600

Mouse Anti Human IL-1 beta FITC
MBS140163-5x1mg 5x1mg
EUR 2375

human anti-human IL-1 β mAb(14)
E4A09D02-14 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-1 β mAb(7Z)
E4A09D02-7Z 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Monoclonal Mouse anti Human IL-1 beta
MBS550073-05mg 0.5mg
EUR 595

Monoclonal Mouse anti Human IL-1 beta
MBS550073-1mg 1mg
EUR 915

Mouse Anti Human IL-1 beta Biotinylated
MBS140162-05mg 0.5mg
EUR 440

Mouse Anti Human IL-1 beta Biotinylated
MBS140162-1mg 1mg
EUR 600

Mouse Anti Human IL-1 beta Biotinylated
MBS140162-5x1mg 5x1mg
EUR 2375

TNF-R2 (human)
TN-004 50 µg
EUR 738

anti-PKA R2
YF-PA24454 50 ul
EUR 400.8
Description: Mouse polyclonal to PKA R2

anti-PKA R2
YF-PA13990 50 ul
EUR 435.6
Description: Mouse polyclonal to PKA R2

human anti-human IL-5 mAb
E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb
E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-4 mAb
E409C13-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb
E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb
E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.

Human anti-Human IL-2 mAb
MBS8576800-005mg 0.05mg
EUR 325

Human anti-Human IL-2 mAb
MBS8576800-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF635 0.1mL(AF635)
EUR 565

Human anti-Human IL-4 mAb
MBS8576802-005mg 0.05mg
EUR 325

Human anti-Human IL-4 mAb
MBS8576802-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-4 mAb
MBS8576802-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-4 mAb
MBS8576802-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-4 mAb
MBS8576802-01mLAF635 0.1mL(AF635)
EUR 565

Human anti-Human IL-5 mAb
MBS8576804-005mg 0.05mg
EUR 325

Human anti-Human IL-5 mAb
MBS8576804-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF635 0.1mL(AF635)
EUR 565

Human anti-Human IL-8 mAb
MBS8576808-005mg 0.05mg
EUR 325

Human anti-Human IL-8 mAb
MBS8576808-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF635 0.1mL(AF635)
EUR 565

human anti-human IL-1β mAb
E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb
E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.

Human anti-Human IL-10 mAb
MBS8576810-005mg 0.05mg
EUR 325

Human anti-Human IL-10 mAb
MBS8576810-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF635 0.1mL(AF635)
EUR 565

human anti-human IL-17A mAb
E409C18-h100 100μL
EUR 276.5
Description: Inflammation Storm Antibodies

Human anti-Human IL-1beta mAb
MBS8576798-005mg 0.05mg
EUR 325

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF635 0.1mL(AF635)
EUR 565

human anti-human IL-12/IL-23 p40 mAb(3H2)
E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)
E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(1G11)
E4A09D33-1G11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Mouse anti Human IL-1RAcP/IL-1R3 Monoclonal Antibody
MBS2543245-006mL 0.06mL
EUR 250

Mouse anti Human IL-1RAcP/IL-1R3 Monoclonal Antibody
MBS2543245-012mL 0.12mL
EUR 370

Mouse anti Human IL-1RAcP/IL-1R3 Monoclonal Antibody
MBS2543245-02mL 0.2mL
EUR 550

Mouse anti Human IL-1RAcP/IL-1R3 Monoclonal Antibody
MBS2543246-006mL 0.06mL
EUR 250

Mouse anti Human IL-1RAcP/IL-1R3 Monoclonal Antibody
MBS2543246-012mL 0.12mL
EUR 370

Mouse anti Human IL-1RAcP/IL-1R3 Monoclonal Antibody
MBS2543246-02mL 0.2mL
EUR 550

Anti-Human TGF beta R2 Antibody
101-M178 100 µg
EUR 399
Description: Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

ApoE R2, Recombinant Human
MBS636329-005mg 0.05mg
EUR 880

ApoE R2, Recombinant Human
MBS636329-5x005mg 5x0.05mg
EUR 3730

MOUSE ANTI HUMAN CD126 (IL-6R)
MBS213171-01mg 0.1mg
EUR 355

MOUSE ANTI HUMAN CD126 (IL-6R)
MBS213171-5x01mg 5x0.1mg
EUR 1425

In vitro fertilisation with preimplantation genetictesting: the need for expanded insurance coverage

Technological advances in genetic testing have enabled prospective parents to learn about their risk of passing a genetic condition to their future children.
One option for those who want to ensure that their biological children do not inherit a genetic condition is to create embryos through in vitro fertilisation (IVF) and use a technique called preimplantation genetic testing (PGT) to screen embryos for genetic abnormalities before implantation.
Unfortunately, due to its high cost, IVF-with-PGT is out of reach for the vast majority of Americans. This article addresses an issue that has been underexplored in the medical ethics literature: the lack of insurance coverage for IVF-with-PGT.Within the US system, a key concept in insurance is that of medically necessary care, which broadly consists of diagnostic services and treatment services. In this article, I argue that IVF-with-PGT could be classified as either a diagnostic service or as a treatment service.
To make this case, I show that IVF-with-PGT is similar to other types of services that are often covered by US insurance providers. In light of these similarities, I argue that the current system is inconsistent with respect to what is-and is not-covered by insurance. To promote consistency and fairness in coverage, like cases should be treated alike-starting with greater coverage for IVF-with-PGT.

Lack of familiarity with genetictesting among patients in Ireland with Cancer

Background: Cancer gene panel testing is available in Ireland. The need for a clear strategy to deal with patient information generated from tumour genomic testing is recognised as a challenge in the National Cancer Strategy. However, the public’s attitude and opinions regarding these results is not known in Ireland.
Aims: This prospective questionnaire study assessed the knowledge and opinions of patients in a national oncology centre, surrounding cancer gene panel testing.
Methods: An anonymised modified validated questionnaire was completed by volunteering patients in the medical oncology department. It comprised 14 questions which assessed patient’s familiarity, intention, benefits and concerns associated with tumour genetic testing using a four-point Likert scale. Patients recorded their primary cancer diagnosis and family cancer history.
Results: Eighty-four patients completed the questionnaire with 77 (92%) patients declaring their primary cancer diagnosis. The median age was 56 (range 26 to 83) years. Overall, 42% (n = 35) of oncology patients were familiar/somewhat familiar with testing and 90% (n = 76) stated they would avail of genetic testing if available. Patients with breast cancer were no more likely to avail of genetic testing when compared with the non-breast cancer cohort (n = 21 vs. 56, p = 0.58) though they identified concerns with potential discrimination.
Conclusion: This is the first prospective Irish study to assess opinions surrounding cancer gene results. Addressing patient’s lack of information as regards genetic testing is the first step in establishing a national cancer genetics testing programme in Ireland.

human anti-human IL-8 mAb(1F)
E4A09D07-1F 100ug
EUR 595

human anti-human IL-8 mAb(A5)
E4A09D07-A5A 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb(6G)
E4A09D07-B5G 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb(AB)
E4A09D07-C8A 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb(N2)
E4A09D07-N2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-8 mAb(N8)
E4A09D07-N8 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-Human IL-8
GWB-BIG258 500ug Ask for price

human anti-human IL-8 mAb (1H) Humanized Antibody
MBS8574794-01mg 0.1mg
EUR 505

human anti-human IL-8 mAb (1H) Humanized Antibody
MBS8574794-5x01mg 5x0.1mg
EUR 2015

human anti-human IL-8 mAb (2H) Humanized Antibody
MBS8574795-01mg 0.1mg
EUR 505

human anti-human IL-8 mAb (2H) Humanized Antibody
MBS8574795-5x01mg 5x0.1mg
EUR 2015

Human Interleukin-8 (IL-8) Antibody
13102-05011 150 ug
EUR 175

Human IL-8
90258-A 5 µg
EUR 130
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli.

Human IL-8
90258-B 25 µg
EUR 205
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli.

human IL-8
M851530020 1 unit
EUR 804.84

Anti-Human IL-8 Antibody
101-M08 500 µg
EUR 246.75
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10.

Anti-Human IL-8 Antibody
102-P38 100 µg
EUR 245.7
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10.

Anti-Human IL-8 Antibody
GWB-817E77 1 mL Ask for price

mAb anti-Human IL-8
MBS592019-01mg 0.1mg
EUR 365

mAb anti-Human IL-8
MBS592019-05mg 0.5mg
EUR 530

mAb anti-Human IL-8
MBS592019-5x05mg 5x0.5mg
EUR 2140

mAb anti-Human IL-8
MBS592095-01mg 0.1mg
EUR 365

mAb anti-Human IL-8
MBS592095-05mg 0.5mg
EUR 530

mAb anti-Human IL-8
MBS592095-5x05mg 5x0.5mg
EUR 2140

mAb anti-Human IL-8
MBS592159-01mg 0.1mg
EUR 365

mAb anti-Human IL-8
MBS592159-05mg 0.5mg
EUR 545

mAb anti-Human IL-8
MBS592159-5x05mg 5x0.5mg
EUR 2205

mAb anti-Human IL-8
MBS592219-01mg 0.1mg
EUR 365

mAb anti-Human IL-8
MBS592219-05mg 0.5mg
EUR 545

mAb anti-Human IL-8
MBS592219-5x05mg 5x0.5mg
EUR 2205

mAb anti-Human IL-8
MBS592256-01mg 0.1mg
EUR 365

mAb anti-Human IL-8
MBS592256-05mg 0.5mg
EUR 530

mAb anti-Human IL-8
MBS592256-5x05mg 5x0.5mg
EUR 2140

Anti-Human IL-8 (CXCL8)
MBS550689-01mg 0.1mg
EUR 260

Anti-Human IL-8 (CXCL8)
MBS550689-02mg 0.2mg
EUR 335

Mouse Anti-Human IL-8
MBS690051-05mg 0.5mg
EUR 525

Mouse Anti-Human IL-8
MBS690051-5x05mg 5x0.5mg
EUR 2080

Human IL-8 (77aa)
MBS691916-0005mg 0.005mg
EUR 300

Human IL-8 (77aa)
MBS691916-0025mg 0.025mg
EUR 450

Human IL-8 (77aa)
MBS691916-5x0025mg 5x0.025mg
EUR 1725

IL-8 (72aa), Human
MBS8575167-0005mg 0.005mg
EUR 245

IL-8 (72aa), Human
MBS8575167-5x0005mg 5x0.005mg
EUR 940

IL-8/CXCL8, Human
HY-P7224 50ug
EUR 596.4

Human CXCL8 (IL-8)
MBS444011-0005mg 0.005mg
EUR 150

Human CXCL8 (IL-8)
MBS444011-002mg 0.02mg
EUR 210

Human CXCL8 (IL-8)
MBS444011-005mg 0.05mg
EUR 325

Human CXCL8 (IL-8)
MBS444011-01mg 0.1mg
EUR 480

Human CXCL8 (IL-8)
MBS444011-1mg 1mg
EUR 1910

Human CXCL8 (IL-8)
MBS444019-0002mg 0.002mg
EUR 195

Human CXCL8 (IL-8)
MBS444019-001mg 0.01mg
EUR 530

Human CXCL8 (IL-8)
MBS444019-005mg 0.05mg
EUR 1760

Human CXCL8 (IL-8)
MBS444019-01mg 0.1mg
EUR 2890

Human IL-8 Protein
abx060803-25ug 25 ug
EUR 644.4

Human IL-8 Protein
abx060804-25ug 25 ug
EUR 644.4

Human IL-8 Protein
E2RB20061PT 100ul
EUR 485
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human IL-8 protein
MBS9719016-001mg 0.01mg
EUR 115

Human IL-8 protein
MBS9719016-005mg 0.05mg
EUR 225

Human IL-8 protein
MBS9719016-01mg 0.1mg
EUR 345

Human IL-8 protein
MBS9719016-1mg 1mg
EUR 1745

Human IL-8 protein
MBS9719016-5x1mg 5x1mg
EUR 7815

Human IL-8 protein
PRP1022-100ug 100 μg
EUR 449
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein
PRP1022-10ug 10 μg
EUR 59
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein
PRP1022-1mg 1 mg
EUR 2609
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein
PRP1022-50ug 50 μg
EUR 249
Description: Human IL-8 protein, expressed in E. coli

Recombinant Human IL-8 (72a.a.)(rHu IL-8/CXCL8)
701081 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.

Recombinant Human IL-8 (77a.a.)(rHu IL-8/CXCL8)
701082 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.

Recombinant Human IL-8 (72a.a.) (rHu IL-8/CXCL8)
MBS9419956-0025mL 0.025mL
EUR 280

Recombinant Human IL-8 (72a.a.) (rHu IL-8/CXCL8)
MBS9419956-5x0025mL 5x0.025mL
EUR 1120

Recombinant Human IL-8
6487 5 µg
EUR 194

Recombinant Human IL-8
MBS258218-0005mg 0.005mg
EUR 305

Recombinant Human IL-8
MBS258218-5x0005mg 5x0.005mg
EUR 1210

Recombinant Human IL-8
MBS7608414-005mg 0.05mg
EUR 345

Recombinant Human IL-8
MBS7608414-02mg 0.2mg
EUR 635

Recombinant Human IL-8
MBS7608414-1mg 1mg
EUR 1800

Recombinant Human IL-8
MBS7608414-5x1mg 5x1mg
EUR 6955

Recombinant Human IL-8
SJB05-01 25µg/vial
EUR 342

Anti-CXCL8 / IL-8 Reference Antibody (Genentech anti-IL-8)
E24CHA784 100 μg
EUR 225
Description: Available in various conjugation types.

Interleukin-8 (IL-8) (72a.a) Human
GWB-3997EC 0.025 mg Ask for price

Interleukin 8, Recombinant, Human (IL-8)
MBS650704-01mg 0.1mg
EUR 475

Interleukin 8, Recombinant, Human (IL-8)
MBS650704-05mg 0.5mg
EUR 775

Interleukin 8, Recombinant, Human (IL-8)
MBS650704-5x05mg 5x0.5mg
EUR 3330

Interleukin 8, Recombinant, Human (IL-8)
MBS650074-0025mg 0.025mg
EUR 665

Interleukin 8, Recombinant, Human (IL-8)
MBS650074-5x0025mg 5x0.025mg
EUR 2845

Anti-Human IL-8 (257) Antibody
MBS4158332-01mg 0.1mg
EUR 685

Anti-Human IL-8 (257) Antibody
MBS4158332-5x01mg 5x0.1mg
EUR 2820

Anti-Human IL-8 (807) Antibody
MBS4158333-01mg 0.1mg
EUR 685

Anti-Human IL-8 (807) Antibody
MBS4158333-5x01mg 5x0.1mg
EUR 2820

human DIAplex Human Inflammation - IL-8, IL-17a,
M880130004 1 unit
EUR 650.27

Anti-IL-8 Antibody
A2062-100 100 µg
EUR 472.8

Anti-IL-8 Antibody
ER1706-67 100ul
EUR 189
Description: Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst. IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response and has been demonstrated to be a signatory chemokine of CR2+ naive T cells, also known as recent thymic emigrants. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers.

Anti-IL-8 Antibody
ER1901-61 100ul
EUR 189
Description: IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst.IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers.

Anti-IL-8 antibody
MBS175692-01mg 0.1mg
EUR 450

Anti-IL-8 antibody
MBS175692-5x01mg 5x0.1mg
EUR 1870

Anti-IL-8 Antibody
MBS415375-01mL 0.1mL
EUR 440

Anti-IL-8 Antibody
MBS415375-5x01mL 5x0.1mL
EUR 1720

Anti-IL-8 Antibody
MBS821263-003mL 0.03mL
EUR 185

Anti-IL-8 Antibody
MBS821263-01mL 0.1mL
EUR 255

Anti-IL-8 Antibody
MBS821263-02mL 0.2mL
EUR 335

Anti-IL-8 Antibody
MBS821263-5x02mL 5x0.2mL
EUR 1420

Anti-IL-8 antibody
STJ98175 100 µl
EUR 280.8
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody
STJ97710 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody
STJ97717 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody
STJ97720 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 Antibody
R1511-15 100ul
EUR 189

Anti-IL-8 Antibody
Y123169 100 µl
EUR 320

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