Primary prevention of sickle cell disease

0 Comments
myasthenickids

Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective

  • For couples with sickle cell trait (SCT) who are at risk for having a child with sickle cell disease (SCD), cost is a barrier to using in vitro fertilization (IVF) with preimplantation genetic testing for monogenic diseases (PGT-M) and insurance coverage is not universal.
  • The objective of this study was to evaluate the cost-effectiveness of IVF+PGT-M for couples who both carry SCT and wish to avoid SCD in a child compared to natural conception with the possible birth of a child with SCD, and the associated lifetime medical costs and lost income. A cost-effectiveness analysis was performed with a decision analytic model. Sensitivity analyses, including Monte Carlo Simulations, assessed the impact of changes in input parameters on the incremental cost-effectiveness ratio (ICER).
  • Probabilities and cost estimates were derived from the published literature. Effectiveness was measured in life years (LY) gained. The ICER was calculated to determine the cost-effectiveness of the IVF+PGT-M intervention. Compared to natural conception, IVF+PGT-M had an effectiveness gain of 30 LY, an additional cost of $572,392.68 per individual conceived, and an ICER of $19,319 per LY gained.
  • The ICER is lower than a conservative, preset willingness to pay (WTP) threshold of $50,000 per LY gained. Monte Carlo Simulations demonstrated that, in 91% of iterations, IVF+PGT-M was cost-effective at the WTP of $50,000. IVF+PGT-M is a cost-effective strategy to avoid conceiving a child with SCD and broader insurance coverage is warranted. This article is protected by copyright. All rights reserved.
myasthenickids
myasthenickids

IL-1 R2 ELISA Kit (Human) : 96 Wells (OKAG00129)

OKAG00129 96 Wells
EUR 715.2
Description: Description of target: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 32 pg/mL

Recombinant Mouse IL-1 R2/IL-1 RII Protein

RP00726 10μg
EUR 136.5

anti-PKA R2

YF-PA13990 50 ul
EUR 435.6
Description: Mouse polyclonal to PKA R2

anti-PKA R2

YF-PA24454 50 ul
EUR 400.8
Description: Mouse polyclonal to PKA R2

TNF-R2 (human)

TN-004 50 µg
EUR 738

Anti‐Human IL‐17A

E2790213 100ul
EUR 225
Description: Available in various conjugation types.

Anti-GABAB R2 antibody

STJ96379 200 µl
EUR 236.4
Description: Rabbit polyclonal to GABAB R2.

Anti-TNF-R2 antibody

STJ96053 200 µl
EUR 236.4
Description: Rabbit polyclonal to TNF-R2.

Anti-TRAIL-R2 Antibody

A00410-1 200ug
EUR 565.2
Description: Goat Polyclonal TRAIL-R2 Antibody. Validated in IF, WB and tested in Human, Mouse.

Anti-MonoMethylH3R2me1-(R2) antibody

STJ24010 100 µl
EUR 471.6
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.

Anti-PKA R2 (6A9)

YF-MA10721 100 ug
EUR 435.6
Description: Mouse monoclonal to PKA R2

Anti-PKA R2 (3C7)

YF-MA14876 100 ug
EUR 435.6
Description: Mouse monoclonal to PKA R2

IL 1 R2 Recombinant Protein His Tag Lyophilized

IIL1R2RHISLY100UG each
EUR 721
Description: IL 1 R2 Recombinant Protein His Tag Lyophilized

Anti-Human TGF beta R2 Antibody

101-M178 100 µg
EUR 399
Description: Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

human anti-human IL-1 β mAb(14)

E4A09D02-14 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-1 β mAb(7Z)

E4A09D02-7Z 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5

CABT-L4486-1mg 1 mg
EUR 1076.4

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5

CABT-L4486-5mg 5 mg
EUR 2886

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5

CABT-L4486 1 mg; 5 mg Ask for price
Description: Rat

Mouse Monoclonal anti-human FGF-R2

hAP-0278 100ug
EUR 250

Mouse Monoclonal anti-human FGF-R2

hAP-0278A 100ug
EUR 250

Mouse Monoclonal anti-human Orexin R2

hAP-0850 50ug
EUR 400

Anti- Rabbit Anti-Human DR5 (TRAIL-R2) Antibody

GWB-18A3C7 0.1 mg Ask for price

Sheep Polyclonal anti-human VEGF R2 (KDR, Flk-1)

hAP-5552 50ug
EUR 400

Anti-GABA(B)R2 Antibody

56523 100ug
EUR 466

Anti-Mouse TNF R2 Antibody

103-M134 100 µg
EUR 399
Description: CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF- α and β.

human anti-human IL-5 mAb

E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb

E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-4 mAb

E409C13-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb

E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.

Anti-GABA(B) R2 Purified

11-551-C100 0.1 mg
EUR 198

human anti-human IL-1β mAb

E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb

E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.

PE anti-human CD262 (DR5, TRAIL-R2)

E16FHP262-025 25 tests
EUR 476.67
Description: Available in various conjugation types.

PE anti-human CD262 (DR5, TRAIL-R2)

E16FHP262-100 100 tests
EUR 1083.33
Description: Available in various conjugation types.

APC anti-human CD262 (DR5, TRAIL-R2)

E16FHA262-025 25 tests
EUR 541.67
Description: Available in various conjugation types.

APC anti-human CD262 (DR5, TRAIL-R2)

E16FHA262-100 100 tests
EUR 1278.33
Description: Available in various conjugation types.

human anti-human IL-12/IL-23 p40 mAb(3H2)

E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)

E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(1G11)

E4A09D33-1G11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Purified anti-human CD262 (DR5, TRAIL-R2)

E16FHU262-100U 100 μg
EUR 758.33
Description: Available in various conjugation types.

Mouse Monoclonal anti-human FGF-R2 (IIIB)

hAP-0278C 100ug
EUR 250

Mouse Monoclonal anti-human FGF-R2 Alpha

hAP-0278B 100ug
EUR 250

VEGF-R2 (Human) ELISA Kit

EKA51976-5x96T 5x96T Ask for price

VEGF-R2 (Human) ELISA Kit

EKA51976-96T 96T
EUR 446.9

sTNF-R2 (Human) ELISA Kit

EKA52066-5x96T 5x96T Ask for price

sTNF-R2 (Human) ELISA Kit

EKA52066-96T 96T
EUR 446.9

Human VEGF-R2 ELISA Kit

GWB-SKR160 96 Tests Ask for price

Human sTNF-R2 ELISA Kit

GWB-SKR250 96 Tests Ask for price

TGFbeta-R2 (Human) ELISA Kit

EKA51981-5x96T 5x96T Ask for price

TGFbeta-R2 (Human) ELISA Kit

EKA51981-96T 96T
EUR 446.9

Polyclonal Anti- human IL-3 Antibody

GWB-BBP009 0.1 mg Ask for price

Polyclonal Anti- human IL-4 Antibody

GWB-BBP010 0.1 mg Ask for price

Polyclonal Anti- human IL-6 Antibody

GWB-BBP013 0.1 mg Ask for price

Polyclonal Anti- human IL-7 Antibody

GWB-BBP014 0.1 mg Ask for price

Polyclonal Anti- human IL-10 Antibody

GWB-BBP015 0.1 mg Ask for price

TRAIL-R2, Human Recombinant Protein

TR-005 50 µg
EUR 703

human anti-human IL-2 mAb (D1)

E4A09D03-A7C 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb (F5)

E4A09D03-B1F 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb (16)

E4A09D03-C3C 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (12)

E4A09D04-12 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (52)

E4A09D04-52 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (C1)

E4A09D04-C1 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-6 mAb (A3)

E4A09D06-hA3 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb (A5)

E4A09D07-A5A 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb (6G)

E4A09D07-B5G 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb (AB)

E4A09D07-C8A 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb(N2)

E4A09D07-N2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-8 mAb(N8)

E4A09D07-N8 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-1β mAb (95)

E4A09D02-h9 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-1β mAb (Ca)

E4A09D02-hA 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-1β mAb (Ge)

E4A09D02-hB 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-6 mAb (10C)

E4A09D06-h10C 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-6 mAb (2D2)

E4A09D06-hD2 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-10 mAb (97)

E4A09D08-A9D 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-10 mAb (18)

E4A09D08-B2G 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-15 mAb(1A)

E4A09D21-1A 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

In vitro fertilisation with preimplantation genetictesting: the need for expanded insurance coverage

Technological advances in genetic testing have enabled prospective parents to learn about their risk of passing a genetic condition to their future children.
One option for those who want to ensure that their biological children do not inherit a genetic condition is to create embryos through in vitro fertilisation (IVF) and use a technique called preimplantation genetic testing (PGT) to screen embryos for genetic abnormalities before implantation.
Unfortunately, due to its high cost, IVF-with-PGT is out of reach for the vast majority of Americans. This article addresses an issue that has been underexplored in the medical ethics literature: the lack of insurance coverage for IVF-with-PGT.Within the US system, a key concept in insurance is that of medically necessary care, which broadly consists of diagnostic services and treatment services. In this article, I argue that IVF-with-PGT could be classified as either a diagnostic service or as a treatment service.
To make this case, I show that IVF-with-PGT is similar to other types of services that are often covered by US insurance providers. In light of these similarities, I argue that the current system is inconsistent with respect to what is-and is not-covered by insurance. To promote consistency and fairness in coverage, like cases should be treated alike-starting with greater coverage for IVF-with-PGT.

Lack of familiarity with genetictesting among patients in Ireland with Cancer

Background: Cancer gene panel testing is available in Ireland. The need for a clear strategy to deal with patient information generated from tumour genomic testing is recognised as a challenge in the National Cancer Strategy. However, the public’s attitude and opinions regarding these results is not known in Ireland.
Aims: This prospective questionnaire study assessed the knowledge and opinions of patients in a national oncology centre, surrounding cancer gene panel testing.
Methods: An anonymised modified validated questionnaire was completed by volunteering patients in the medical oncology department. It comprised 14 questions which assessed patient’s familiarity, intention, benefits and concerns associated with tumour genetic testing using a four-point Likert scale. Patients recorded their primary cancer diagnosis and family cancer history.
Results: Eighty-four patients completed the questionnaire with 77 (92%) patients declaring their primary cancer diagnosis. The median age was 56 (range 26 to 83) years. Overall, 42% (n = 35) of oncology patients were familiar/somewhat familiar with testing and 90% (n = 76) stated they would avail of genetic testing if available. Patients with breast cancer were no more likely to avail of genetic testing when compared with the non-breast cancer cohort (n = 21 vs. 56, p = 0.58) though they identified concerns with potential discrimination.
Conclusion: This is the first prospective Irish study to assess opinions surrounding cancer gene results. Addressing patient’s lack of information as regards genetic testing is the first step in establishing a national cancer genetics testing programme in Ireland.

Anti-Human IL-8 Antibody

101-M08 500 µg
EUR 246.75
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10.

Anti-Human IL-8 Antibody

GWB-817E77 1 mL Ask for price

Human Interleukin-8 (IL-8) Antibody

13102-05011 150 ug
EUR 175

Human IL-8

90258-A 5 µg
EUR 130
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli.

Human IL-8

90258-B 25 µg
EUR 205
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli.

human IL-8

M851530020 1 unit
EUR 804.84

Anti-CXCL8 / IL-8 Reference Antibody (Genentech anti-IL-8)

E24CHA784 100 μg
EUR 225
Description: Available in various conjugation types.

human-anti-human-IL-8-mAb(1H)

E409C16-hA100 Inflammation-Storm-Antibodies
EUR 276.5
Description: Inflammation Storm Antibodies

human-anti-human-IL-8-mAb(2H)

E409C16-hB100 Inflammation-Storm-Antibodies
EUR 276.5
Description: Inflammation Storm Antibodies

Anti-IL-8 Antibody

ER1706-67 100ul
EUR 189
Description: Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst. IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response and has been demonstrated to be a signatory chemokine of CR2+ naive T cells, also known as recent thymic emigrants. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers.

Anti-IL-8 Antibody

ER1901-61 100ul
EUR 189
Description: IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst.IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers.

Anti-IL-8 Antibody

A00423 1 mL
EUR 1444.8
Description: Rabbit Polyclonal IL-8 Antibody. Validated in IP, WB and tested in Human.

Anti-IL-8 Antibody

A2062-100 100 µg
EUR 472.8

Anti-IL-8 Antibody

R1511-15 100ul
EUR 189

Anti-IL-8 antibody

STJ97710 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody

STJ97717 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody

STJ97720 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody

STJ98175 100 µl
EUR 280.8
Description: Mouse monoclonal to IL-8.

Anti-IL-8 Antibody

Y123169 100 µl
EUR 320

anti-IL-8 (3E4D8)

LF-MA30011 100 ul
EUR 448.8
Description: Mouse Monoclonal to IL-8

Anti- Interleukin-8 (IL-8) Antibody

GWB-7ACF57 0.05 mg Ask for price

mAb mouse anti-human IL-8

CT264 0.5 mg
EUR 312

mouse anti-human IL-8 mAb

E409C16-m100 100μL
EUR 395
Description: Available in various conjugation types.

Recombinant Human IL-8 (72a.a.)(rHu IL-8/CXCL8)

701081 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.

Recombinant Human IL-8 (77a.a.)(rHu IL-8/CXCL8)

701082 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.

IL-8/CXCL8, Human

HY-P7224 50ug
EUR 596.4

Human IL-8 Protein

abx060803-25ug 25 ug
EUR 644.4

Human IL-8 Protein

abx060804-25ug 25 ug
EUR 644.4

Human IL-8 protein

PRP1022-100ug 100 μg
EUR 449
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein

PRP1022-10ug 10 μg
EUR 59
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein

PRP1022-1mg 1 mg
EUR 2609
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein

PRP1022-50ug 50 μg
EUR 249
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 Protein

E2RB20061PT 100ul
EUR 485
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Interleukin-8 (IL-8) (72a.a) Human

GWB-3997EC 0.025 mg Ask for price

Recombinant Human IL-8

6487 5 µg
EUR 194

Recombinant Human IL-8

P0180 100ug
EUR 626.83
Description: Recombinant Human protein for IL-8

Recombinant Human IL-8

SJB05-01 25µg/vial
EUR 342

Human Interleukin-8 (IL-8) Antibody (Biotin Conjugate)

13102-05021 150 ug
EUR 229

Rabbit anti-IL-8 Antibody

DL90596A-100ul 100 ul
EUR 270
Description: CXCL8; Interleukin-8; IL-8; C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor

Rabbit anti-IL-8 Antibody

DL90596A-50ul 50 ul
EUR 189
Description: CXCL8; Interleukin-8; IL-8; C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor

Rabbit anti-IL-8 Antibody

YLD4345-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IL-8

Rabbit anti-IL-8 Antibody

YLD4345-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IL-8

human DIAplex Human Inflammation - IL-8, IL-17a,

M880130004 1 unit
EUR 650.27

Anti-IL-8 Monoclonal Antibody

A00423-1 100ul
EUR 476.4
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat.

Human IL-8 ELISA antibody pair

CT748-10 10-plate
EUR 656.4

Human IL-8 ELISA antibody pair

CT748-20 20-plate
EUR 1118.4

Anti-swine IL-8 PAb

GWB-OC22N2 1 kit Ask for price

Anti-bovine IL-8 PAb

GWB-03EYX4 100 ug Ask for price

Anti-rabbit IL-8 PAb

GWB-VPE0Z2 1 kit Ask for price

Anti-feline IL-8 PAb

GWB-FEZA83 1 kit Ask for price

Anti-dolphin IL-8 PAb

GWB-KI0031 1 kit Ask for price

Anti-Human IL-8 (I8-S2) Antibody

Y052802 100 µg
EUR 490

Anti-Human IL-17 (CTLA-8) Antibody

101-M783 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Mouse Monoclonal anti-Human IL-8 Antibody

xAP-0435 100ug
EUR 280

Mouse Monoclonal anti-Human IL-8 Antibody

xAP-0436 100ug
EUR 280

Mouse Monoclonal anti-Human IL-8 Antibody

xAP-0437 100ug
EUR 280

Anti-Human IL-8 Rabbit Polyclonal Antibody

TA328221 100 µg Ask for price

Human Interleukin 8 (IL-8) CLIA Kit

abx195916-96tests 96 tests
EUR 990

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-24Tests 24 Tests
EUR 180
Description: Sandwich

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-48Tests 48 Tests
EUR 546
Description: Sandwich

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-96Tests 96 Tests
EUR 682
Description: Sandwich

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

mouse anti-human IL-8 mAb(Q10)

E4A09D07-Q10 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

mouse anti-human IL-8 mAb(Q36)

E4A09D07-Q36 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human Interleukin 8,IL-8 ELISA KIT

201-12-0090 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 8(IL-8) Elisa Kit

EK610269 96 Wells
EUR 0.1

Human Interleukin 8(IL-8) Elisa Kit

EK710269 96 Wells
EUR 0.77

Human Interleukin 8 (IL-8) ELISA Kit

EK10257 96Т
EUR 799

Human IL-8(Interleukin 8) ELISA Kit

EH0205 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human IL-8(Interleukin 8) ELISA Kit

EKF57074-48T 48T
EUR 396.9

Human IL-8(Interleukin 8) ELISA Kit

EKF57074-5x96T 5x96T
EUR 2693.25

Human IL-8(Interleukin 8) ELISA Kit

EKF57074-96T 96T
EUR 567

Human Interleukin 8,IL-8 ELISA KIT

EKC40086-48T 48T
EUR 328.86

Human Interleukin 8,IL-8 ELISA KIT

EKC40086-5x96T 5x96T
EUR 2231.55

Human Interleukin 8,IL-8 ELISA KIT

EKC40086-96T 96T
EUR 469.8

Human IL-8 (Interleukin 8) ELISA Kit

EKE60046-5x96T 5x96T
EUR 2667.6

Human IL-8 (Interleukin 8) ELISA Kit

EKE60046-96T 96T
EUR 561.6

Human Interleukin 8(IL-8)ELISA Kit

GA-E0129HM-48T 48T
EUR 346.8

Human Interleukin 8(IL-8)ELISA Kit

GA-E0129HM-96T 96T
EUR 559.2

Human IL-8(Interleukin 8) ELISA Kit

E39EH0205 96T
EUR 595

Human Interleukin 8,IL-8 ELISA KIT

EK0240 96 tests
EUR 659

Human Interleukin 8, IL-8 ELISA KIT

CSB-E04641h-24T 1 plate of 24 wells
EUR 198
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 8, IL-8 ELISA KIT

1-CSB-E04641h
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid(CSF), tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 8 (IL-8) ELISA Kit

AE38177HU-48Tests 48 Tests
EUR 200
Description: Human (Homo sapiens)

Human Interleukin 8 (IL-8) ELISA Kit

AE38177HU-96Tests 96 Tests
EUR 360
Description: Human (Homo sapiens)

Human IL-8(Interleukin 8) ELISA Kit

RE2733H-48wells 48 wells
EUR 125.55

Human IL-8(Interleukin 8) ELISA Kit

RE2733H-96wells 96 wells
EUR 179.55

Human Interleukin 8(IL-8)ELISA Kit

QY-E04259 96T
EUR 433.2

Human Interleukin 8(IL-8)ELISA Kit

NSL1931Hu 96 wells
EUR 468

Human Interleukin 8,IL-8 ELISA Kit

SL1004Hu 96 Tests
EUR 468

Human Interleukin 8,IL-8 ELISA KIT

YLA1210HU-48T 48T Ask for price

Human Interleukin 8,IL-8 ELISA KIT

YLA1210HU-96T 96T Ask for price

Rabbit anti-Human IL-8 mAb (CAP)

RM17646 100μg Ask for price

Rabbit anti-Human IL-8 mAb (DET)

RM17647 100μg Ask for price

Rabbit anti-Human IL-8 mAb (CAP)

RM17648 100μg Ask for price

Rabbit anti-Human IL-8 mAb (DET)

RM17649 100μg Ask for price

Interleukin-8 (IL-8) (77a.a)/CXCL8 Human

GWB-2B4200 0.025 mg Ask for price

Human Interleukin-8 (IL-8) ELISA Kit

LF-EK60006 1×96T
EUR 948

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-24Tests 24 Tests
EUR 150
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-48Tests 48 Tests
EUR 416
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-96Tests 96 Tests
EUR 520
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-96Tests10 96 Tests *10
EUR 5200
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-96Tests5 96 Tests *5
EUR 2600
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-EL-H6008-24Tests 24 Tests
EUR 150
Description: Sandwich

Leave a Reply

Your email address will not be published.