Primary prevention of sickle cell disease

Ivan September 9, 2020 0 Comments
myasthenickids

Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective

  • For couples with sickle cell trait (SCT) who are at risk for having a child with sickle cell disease (SCD), cost is a barrier to using in vitro fertilization (IVF) with preimplantation genetic testing for monogenic diseases (PGT-M) and insurance coverage is not universal.
  • The objective of this study was to evaluate the cost-effectiveness of IVF+PGT-M for couples who both carry SCT and wish to avoid SCD in a child compared to natural conception with the possible birth of a child with SCD, and the associated lifetime medical costs and lost income. A cost-effectiveness analysis was performed with a decision analytic model. Sensitivity analyses, including Monte Carlo Simulations, assessed the impact of changes in input parameters on the incremental cost-effectiveness ratio (ICER).
  • Probabilities and cost estimates were derived from the published literature. Effectiveness was measured in life years (LY) gained. The ICER was calculated to determine the cost-effectiveness of the IVF+PGT-M intervention. Compared to natural conception, IVF+PGT-M had an effectiveness gain of 30 LY, an additional cost of $572,392.68 per individual conceived, and an ICER of $19,319 per LY gained.
  • The ICER is lower than a conservative, preset willingness to pay (WTP) threshold of $50,000 per LY gained. Monte Carlo Simulations demonstrated that, in 91% of iterations, IVF+PGT-M was cost-effective at the WTP of $50,000. IVF+PGT-M is a cost-effective strategy to avoid conceiving a child with SCD and broader insurance coverage is warranted. This article is protected by copyright. All rights reserved.
myasthenickids
myasthenickids
Anti-IL1R2/Il 1 Rii Antibody
A03106-1 1 ml
EUR 397.00
Description: Rabbit Polyclonal IL1R2/Il 1 Rii Antibody. Validated in IP, WB and tested in Human.
anti-PKA R2
YF-PA13990 50 ul
EUR 363.00
Description: Mouse polyclonal to PKA R2
anti-PKA R2
YF-PA24454 50 ul
EUR 334.00
Description: Mouse polyclonal to PKA R2
Anti-IL-31 Antibody
A08339-1 100ug/vial
EUR 334.00
Anti-IL-17B Antibody
A10846-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for IL-17B Antibody (IL17B) detection.tested for IHC in Human, Rat.
Anti-IL-6 Antibody
A00102-1 100ug
EUR 432.00
Description: Rabbit Polyclonal IL-6 Antibody. Validated in Neu, IHC, WB and tested in Human.
Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349.00
Anti-MonoMethylH3R2me1-(R2) antibody
STJ24010 100 µl
EUR 393.00
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
Anti-TNF-R2 antibody
STJ96053 200 µl
EUR 197.00
Description: Rabbit polyclonal to TNF-R2.
Anti-GABAB R2 antibody
STJ96379 200 µl
EUR 197.00
Description: Rabbit polyclonal to GABAB R2.
Anti-PKA R2 (6A9)
YF-MA10721 100 ug
EUR 363.00
Description: Mouse monoclonal to PKA R2
Anti-PKA R2 (3C7)
YF-MA14876 100 ug
EUR 363.00
Description: Mouse monoclonal to PKA R2
Anti-IL-22/IL22 Antibody
A00963-1 100ug/vial
EUR 294.00
Anti-IL-3R beta Antibody
A02219-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for IL-3R beta Antibody (CSF2RB) detection.tested for WB in Human, Mouse, Rat.
Anti-IL-2/IL2 Antibody
A00387-1 100ug/vial
EUR 294.00
Anti-IL-8 Monoclonal Antibody
A00423-1 100ul
EUR 397.00
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat.
Anti-IL-6 Monoclonal Antibody
M00102-1 100ug
EUR 455.00
Description: Mouse Monoclonal IL-6 Antibody. Validated in Flow Cytometry, WB and tested in Human.
Anti-IL-17A Monoclonal Antibody
M00421-1 100ug
EUR 455.00
Description: Mouse Monoclonal IL-17A Antibody. Validated in WB and tested in Human.
Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486-1mg 1 mg
EUR 897.00
Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486-5mg 5 mg
EUR 2405.00
Anti-Human IL-17F Biotin Conjugated Monoclonal Antibody
B02062-1 100ug
EUR 432.00
Description: Mouse Monoclonal Human IL-17F Biotin Conjugated Antibody. Validated in IHC, WB and tested in Human.
Anti-IL-32A Antibody Peroxidase Conjugated
A03286-1 100ug
EUR 455.00
Description: Rabbit Polyclonal IL-32A Antibody Peroxidase Conjugated. Validated in WB and tested in Human.
IL-1 β
E13-003-1 10μg
EUR 213.00
IL-1 α
E13-029-1 10μg
EUR 213.00
Anti-GABA(B) R2 Purified
11-551-C100 0.1 mg
EUR 204.00
IL-1 beta, rat recombinant
P1019-1 1 mg
EUR 7288.00
Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells. Both IL-1? and IL-1? bind to the same receptor and have similar biological properties.
IL-1beta, human recombinant
P1018-1 1 mg
EUR 5061.00
Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells
IL-2, human recombinant
P1020-1 1 mg
EUR 1156.00
Description: Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes and is produced by activated CD4+ and CD8+ T cells, gamma ? T cells, B cells, dendritic cells and eosinophils. IL-2 plays a critical role in immune responses against pathogenic infection
IL-3, human recombinant
P1021-1 1 mg
EUR 4017.00
Description: Interleukin 3 (IL-3) is a pleiotropic cytokine produced by activated T cells, mast cells and eosinophils, and stimulates the proliferation and differentiation of pluripotent hematopoietic stem cells, and committed progenitor cells of the megakaryocyte
IL-7, human recombinant
P1024-1 1 mg
EUR 6940.00
Description: Interleukin-7 (IL-7) is a potent lymphoid cell growth factor produced by bone marrow and thymic stromal cells, spleen cells and keratinocytes. IL7 stimulates the proliferation of Pre-B, Pro-B and early T cells.
Notoginsenoside R2
HY-N0909 10mg
EUR 463.00
Notoginsenoside R2
TN028181 20mg Ask for price
Stipuleanoside R2
TBZ1475 unit Ask for price
Human Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit
EI2200-1 96 Well Plate
EUR 477.00
Human Interleukin-1-alpha (IL-1-alpha) AssayMax ELISA Kit
EI2301-1 96 Well Plate
EUR 477.00
Anti-Phospho-GABAB R2 (Ser783) Antibody
P03830 100ul
EUR 398.00
Description: Rabbit Polyclonal Phospho-GABAB R2 (Ser783) Antibody. Validated in IF, WB and tested in Mouse, Rat.
Recombinant Rat IL-1 Beta Protein
PROTQ63264-1 10ug
EUR 317.00
Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues.
Canine IL-1 alpha Recombinant Protein
R01144-1 5ug/vial
EUR 259.00
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Canine IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast.
Canine IL-1 beta Recombinant Protein
R00101-1 5ug/vial
EUR 259.00
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Canine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.
IL-1-beta Interleukin-1 betaHuman Recombinant Protein
PROTP01584-1 Regular: 10ug
EUR 317.00
Description: Interleukin-1 beta Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton.;The IL-1b is purified by proprietary chromatographic techniques.
IL-1-alpha Interleukin-1 alpha Human Recombinant Protein, His Tag
PROTP01583-1 Regular: 20ug
EUR 317.00
Description: IL-1A Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids fragment (113-271) with an amino-terminal hexahistidine tag and having a total molecular mass of 22.5kDa. ;The Interleukin-1 alpha His-tag is purified by proprietary chromatographic techniques.
IL-10, human recombinant protein
P1028-1 1 mg
EUR 6731.00
Description: Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the synthesis of proinflammatory cytokines such as IL-1 and TNF-? and proliferation of T cells
IL-15, human recombinant protein
P1029-1 1 mg
EUR 5339.00
Description: Interleukin 15 (IL-15) is an immunomodulating cytokine mainly produced by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells and stimulates the proliferation of T lymphocytes.
IL-17A, human recombinant protein
P1030-1 1 mg
EUR 4156.00
Description: Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by Th17 cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases and stimulates the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as the production of nitric oxide (NO).
IL-18, human recombinant protein
P1032-.1 100 µg
EUR 780.00
Description: Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures.
IL-18, human recombinant protein
P1032-1 1 mg
EUR 5061.00
Description: Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures.
IL-21, human recombinant protein
P1033-1 1 mg
EUR 6522.00
Description: Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. IL-21 induces the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells, apoptotic effects in naïve B-cells.
Recombinant Human IL-24 Protein
PROTQ13007-1 20ug
EUR 317.00
Description: IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
Recombinant Human IL-31 Protein
PROTQ6EBC2-1 10ug
EUR 317.00
Description: Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.
Recombinant Human IL-17D Protein
PROTQ8TAD2-1 25ug
EUR 317.00
Description: IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8, and GM-CSF and inhibits hemopoiesis of myeloid progenitor cells in colony forming assays. Recombinant human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.
Recombinant Human IL-22 Protein
PROTQ9GZX6-1 10ug
EUR 317.00
Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.
Recombinant Human IL-17E Protein
PROTQ9H293-1 25ug
EUR 317.00
Description: IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 145 amino acid polypeptide chains.
Recombinant Human IL-20 Protein
PROTQ9NYY1-1 10ug
EUR 317.00
Description: IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-α and type II IL-20R-β. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.
Recombinant Human IL-19 Protein
PROTQ9UHD0-1 10ug
EUR 317.00
Description: IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-α and induces apoptosis through TNF-α. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.
Recombinant Human IL-12 Protein
PROTP29459-1 10ug
EUR 317.00
Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).
Recombinant Murine IL-17 (IL-17A) Protein
PROTQ62386-1 25ug
EUR 317.00
Description: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.
Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280.00
Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280.00
Anti-GABAB Receptor (Ser783), R2-Subunit antibody
STJ120094 100 µl
EUR 526.00
IL-8 (77 a.a.), human recombinant
P1026-1 1 mg
EUR 4226.00
Description: Interleukin-8 (IL-8) is a proinflammatory CXC chemokine produced by macrophages, epithelial cells. IL-8 is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies
TNF-R2 Antibody
AF0364 200ul
EUR 304.00
Description: TNF-R2 antibody detects endogenous levels of total TNF-R2.
TNF-R2 Antibody
AF0365 200ul
EUR 304.00
Description: TNF-R2 antibody detects endogenous levels of total TNF-R2.
TNF- R2 Antibody
ABF0364 100 ug
EUR 438.00
TNF- R2 Antibody
ABF0365 100 ug
EUR 438.00
R-Notoginsenoside R2
N2244-20 20 mg
EUR 572.00
Description: Extracted from Panax Notoginseng dried roots;Store the product in sealed, cool and dry condition
ApoE R2, CF
PR15062CF 50 ug
EUR 461.00
Mouse Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit
EMI2200-1 96 Well Plate
EUR 477.00
Anti-IL-1 Alpha Antibody
A01144 1mg
EUR 1232.00
Description: Rabbit Polyclonal IL-1 Alpha Antibody. Validated in WB and tested in Human.
Anti-IL-1 beta Antibody
A00101-2 1mg
EUR 1232.00
Description: Rabbit Polyclonal IL-1 beta Antibody. Validated in IP, IHC, WB and tested in Human.
anti- IL 1 alpha antibody
FNab04208 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:50 - 1:200
  • Immunogen: interleukin 1, alpha
  • Uniprot ID: P01583
  • Gene ID: 3552
  • Research Area: Stem Cells, Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against IL 1 alpha
Anti-IL 1 alpha antibody
PAab04208 100 ug
EUR 386.00
Anti-IL-1 RII antibody
STJ16100664 100 µg
EUR 742.00
Anti-IL-1 beta antibody
STJ73078 100 µg
EUR 359.00
IL-8 Interleukin-8 (1-77 a.a) Human Recombinant Protein (CXCL8)
PROTP10145-1 Regular: 25ug
EUR 317.00
Description: Interleukin-8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8904 Dalton. ;The IL-8 is purified by proprietary chromatographic techniques.
IL-1RA Interleukin-1 Receptor Antagonist Human Recombinant Protein, His Tag
PROTP18510-1 Regular: 50ug
EUR 682.00
Description: IL1Ra Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.63kDa with an amino-terminal hexahistidine tag. ;The IL-1Ra His is purified by proprietary chromatographic techniques.
IL-2
E13-013-1 10μg
EUR 161.00
IL-4
E13-015-1 10μg
EUR 161.00
IL-6
E13-016-1 10μg
EUR 161.00

In vitro fertilisation with preimplantation genetictesting: the need for expanded insurance coverage

Technological advances in genetic testing have enabled prospective parents to learn about their risk of passing a genetic condition to their future children.
One option for those who want to ensure that their biological children do not inherit a genetic condition is to create embryos through in vitro fertilisation (IVF) and use a technique called preimplantation genetic testing (PGT) to screen embryos for genetic abnormalities before implantation.
Unfortunately, due to its high cost, IVF-with-PGT is out of reach for the vast majority of Americans. This article addresses an issue that has been underexplored in the medical ethics literature: the lack of insurance coverage for IVF-with-PGT.Within the US system, a key concept in insurance is that of medically necessary care, which broadly consists of diagnostic services and treatment services. In this article, I argue that IVF-with-PGT could be classified as either a diagnostic service or as a treatment service.
To make this case, I show that IVF-with-PGT is similar to other types of services that are often covered by US insurance providers. In light of these similarities, I argue that the current system is inconsistent with respect to what is-and is not-covered by insurance. To promote consistency and fairness in coverage, like cases should be treated alike-starting with greater coverage for IVF-with-PGT.

Lack of familiarity with genetictesting among patients in Ireland with Cancer

Background: Cancer gene panel testing is available in Ireland. The need for a clear strategy to deal with patient information generated from tumour genomic testing is recognised as a challenge in the National Cancer Strategy. However, the public’s attitude and opinions regarding these results is not known in Ireland.
Aims: This prospective questionnaire study assessed the knowledge and opinions of patients in a national oncology centre, surrounding cancer gene panel testing.
Methods: An anonymised modified validated questionnaire was completed by volunteering patients in the medical oncology department. It comprised 14 questions which assessed patient’s familiarity, intention, benefits and concerns associated with tumour genetic testing using a four-point Likert scale. Patients recorded their primary cancer diagnosis and family cancer history.
Results: Eighty-four patients completed the questionnaire with 77 (92%) patients declaring their primary cancer diagnosis. The median age was 56 (range 26 to 83) years. Overall, 42% (n = 35) of oncology patients were familiar/somewhat familiar with testing and 90% (n = 76) stated they would avail of genetic testing if available. Patients with breast cancer were no more likely to avail of genetic testing when compared with the non-breast cancer cohort (n = 21 vs. 56, p = 0.58) though they identified concerns with potential discrimination.
Conclusion: This is the first prospective Irish study to assess opinions surrounding cancer gene results. Addressing patient’s lack of information as regards genetic testing is the first step in establishing a national cancer genetics testing programme in Ireland.

Anti-IL-8 antibody
STJ97717 200 µl
EUR 197.00
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody
STJ97720 200 µl
EUR 197.00
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody
STJ98175 100 µl
EUR 234.00
Description: Mouse monoclonal to IL-8.

Anti-IL-8 Antibody
A2062-100 100 µg
EUR 394.00

1730 8 SNAP-SEAL 8 OZ
1730-8 100/pk
EUR 74.00
Description: Disposable Plastic; Plastic Containers

mAb mouse anti-human IL-8
CT264 0.5 mg
EUR 260.00

Anti-IL-8 Monoclonal Antibody
A00423-1 100ul
EUR 397.00
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat.

IL-8
E5-00004 1mg
EUR 960.00

Swine IL-6 Recombinant Protein
R00102-8 5ug/vial
EUR 259.00
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Swine IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Swine IL-4 Recombinant Protein
R00230-8 5ug/vial
EUR 259.00
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Swine IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

Rabbit IL-2 Recombinant Protein
R00387-8 5ug/vial
EUR 259.00
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Rabbit IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

Swine IL-17A Recombinant Protein
R00421-8 5ug/vial
EUR 259.00
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Swine IL-17A Recombinant Protein is purified interleukin-17A produced in yeast.

Individual Reaction Mix 8
G065-8 200 reactions
EUR 167.00

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349.00

Human Interleukin-8 (IL-8) Antibody
13102-05011 150 ug
EUR 207.00

Ovine IL-1 beta Recombinant Protein
R00101-8 5ug/vial
EUR 259.00
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Ovine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

IL-8/CXCL8, Human
HY-P7224 50ug
EUR 497.00

Human IL-8 Protein
abx060803-25ug 25 ug
EUR 537.00
  • Shipped within 5-10 working days.

Human IL-8 Protein
abx060804-25ug 25 ug
EUR 537.00
  • Shipped within 5-10 working days.

Human IL-8 Antibody
33486-05111 150 ug
EUR 261.00

Recombinant Human IL-8
P0180 100ug
EUR 522.36
  • Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose
  • Reconstitution: Sterile distilled water
  • Purity: Greater than 95% by SDS-PAGE gel analyses
  • Uniprot ID: P10145
Description: Recombinant Human protein for IL-8

Recombinant Human IL-8
SJB05-01 25µg/vial
EUR 285.00

Anti-bovine IL-8 (CXCL8) antibody
STJ15100008 250 µg
EUR 336.00
Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot.

Anti-bovine IL-8 (CXCL8) antibody
STJ15100009 250 µg
EUR 336.00
Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA.

IL-8 Antibody
BF0238 200ul
EUR 376.00
Description: IL-8 antibody detects endogenous levels of total IL-8.

CXCL8/IL-8
E21-C97 10ug
EUR 343.00

CXCL8/IL-8
GT15156 100 ug
EUR 526.00

IL-8 Inhibitor
H-2268.0001 1.0mg
EUR 167.00
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

IL-8 Inhibitor
H-2268.0005 5.0mg
EUR 576.00
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

IL-8 Inhibitor
H-2268.0025 25.0mg
EUR 2207.00
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

IL-8 Inhibitor
5-01378 4 x 5mg Ask for price

IL-8 Antibody
5149-100
EUR 338.00

Bovine(IL-8)
QY-E60063 96T
EUR 426.00

IL-8, Interleukin-8, monkey
RC222-19 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Human IL-8(Interleukin 8) ELISA Kit
EH0205 96T
EUR 476.25
  • Detection range: 31.25-2000 pg/ml
  • Uniprot ID: P10145
  • Alias: IL-8/IL8/CXCL8/GCP-1/GCP1/LECT/LUCT/LYNAP/MDNCF/MONAP/NAF/NAP-1/NAP1/3-10C/AMCF-I/K60
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human Interleukin 8(IL-8)ELISA Kit
GA-E0129HM-48T 48T
EUR 289.00

Human Interleukin 8(IL-8)ELISA Kit
GA-E0129HM-96T 96T
EUR 466.00

Human Interleukin 8 (IL-8) CLIA Kit
abx195916-96tests 96 tests
EUR 825.00
  • Shipped within 5-12 working days.

Human Interleukin 8,IL-8 ELISA KIT
201-12-0090 96 tests
EUR 440.00
  • This Interleukin 8 ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 8, IL-8 ELISA KIT
CSB-E04641h-24T 1 plate of 24 wells
EUR 165.00
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 8, IL-8 ELISA KIT
1-CSB-E04641h
  • EUR 500.00
  • EUR 3402.00
  • EUR 1820.00
  • 0
  • 1
  • 2
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid(CSF), tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin-8 (IL-8) ELISA Kit
LF-EK60006 1×96T
EUR 790.00

Human Interleukin 8(IL-8)ELISA Kit
QY-E04259 96T
EUR 361.00

Bovine Cytokines IL-8(Cytokines IL-8) ELISA Kit
QY-E60102 96T
EUR 426.00

Human IL-8 ELISA Kit
EHI0063 96Tests
EUR 521.00

human IL-8 His tag
E410A07-100 100μg
EUR 960.00

IL-8 ELISA KIT|Human
EF003990 96 Tests
EUR 689.00

rec Endothelial IL-8 (human)
H-3742.0010 10.0µg
EUR 284.00
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9]

rec Endothelial IL-8 (human)
H-3742.0050 50.0µg
EUR 973.00
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9]

rec Monocyte IL-8 (human)
H-9625.0005 5.0µg
EUR 162.00
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8]

rec Monocyte IL-8 (human)
H-9625.0025 25.0µg
EUR 381.00
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8]

IL-8/CXCL8, 72a.a., Human
HY-P7380 50ug
EUR 497.00

IL-8 (Human) ELISA Kit
K4169-100
EUR 729.00

Human IL-8 ELISA kit
CT212A 5-plate
EUR 462.00

Human IL-8 ELISA kit
LF-EK50165 1×96T
EUR 648.00

Recombinant Human IL-8 Protein
RP00052 5 μg
EUR 149.00

Guinea pig IL-8(Interleukin 8)
EGP0055 96T
EUR 567.60
  • Detection range: 15.6-1000 pg/ml
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Guinea pig;Sensitivity: 9.375pg/ml

Horse Interleukin 8 (IL-8) ELISA
QY-E120050 96T
EUR 478.00

IL-8, CXCL8, Interleukin-8, canine
RC242-19 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

IL-8, CXCL8, Interleukin-8, porcine
RC282-19 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Recombinant Human Interleukin-8/IL-8 (C-6His)
CC97-10ug 10ug
EUR 146.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)
CC97-1mg 1mg
EUR 2283.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)
CC97-500ug 500ug
EUR 1613.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)
CC97-50ug 50ug
EUR 339.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)
C035-10ug 10ug
EUR 151.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)
C035-1mg 1mg
EUR 1836.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)
C035-500ug 500ug
EUR 1298.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)
C035-50ug 50ug
EUR 354.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)
C037-10ug 10ug
EUR 151.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)
C037-1mg 1mg
EUR 1836.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)
C037-500ug 500ug
EUR 1298.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)
C037-50ug 50ug
EUR 344.00
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Human Interleukin-8 (IL-8) AssayMax ELISA Kit
EI1008-1 96 Well Plate
EUR 477.00

ELISA kit for Human Interleukin 8,IL-8
EK0240 96 tests
EUR 603.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Interleukin 8,IL-8 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Interleukin-8 (IL-8) Antibody (Biotin Conjugate)
13102-05021 150 ug
EUR 261.00

CLIA kit for Human IL-8 (Interleukin 8)
E-CL-H0048 1 plate of 96 wells
EUR 584.00
  • Gentaur's IL-8 CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Human IL-8 . Standards or samples are added to the micro CLIA plate wells and combined with the
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human IL-8 (Interleukin 8)
E-EL-H0048 1 plate of 96 wells
EUR 377.00
  • Gentaur's IL-8 ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-8. Standards or samples are added to the micro ELISA plate wells and combined with th
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant

IL-8, CXCL8, Interleukin-8 (72 a.a.), human
RC212-19A 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

IL-8, CXCL8, Interleukin-8 (77 a.a.), human
RC212-19B 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Polyclonal IL-8 Antibody
APR00274G 0.1mg
EUR 484.00
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-8 . This antibody is tested and proven to work in the following applications:

IL-8 Blocking Peptide
BF0238-BP 1mg
EUR 195.00

IL-8 Polyclonal Antibody
ES2620-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES2620-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES5885-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES5885-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES3883-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES3883-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody
ABP52884-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody
ABP52884-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody
ABP52884-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody
ABP51621-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP51621-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP51621-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP54886-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP54886-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP54886-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human IL-8
  • Applications tips:
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
41063-100ul 100ul
EUR 252.00

IL-8 Polyclonal Antibody
41063-50ul 50ul
EUR 187.00

CXCR1/IL-8 RA
MO15072 500 ug
EUR 910.00

CXCR2/IL-8 RB
MO15073 100 ug
EUR 474.00

CXCR2/IL-8 RB
MO15084 100 ug
EUR 474.00

Recombinant Bovine IL-8
P0176 100ug
EUR 522.36
  • Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose
  • Reconstitution: Sterile distilled water
  • Purity: Greater than 95% by SDS-PAGE gel analyses
  • Uniprot ID: P79255
Description: Recombinant Bovine protein for IL-8

Recombinant Chicken IL-8
P0177 100ug
EUR 522.36
  • Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose
  • Reconstitution: Sterile distilled water
  • Purity: Greater than 95% by SDS-PAGE gel analyses
  • Uniprot ID: P08317
Description: Recombinant Chicken protein for IL-8

Recombinant Dog IL-8
P0178 100ug
EUR 522.36
  • Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose
  • Reconstitution: Sterile distilled water
  • Purity: Greater than 95% by SDS-PAGE gel analyses
  • Uniprot ID: P41324
Description: Recombinant Dog protein for IL-8

Recombinant Pig IL-8
P0181 100ug
EUR 522.36
  • Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose
  • Reconstitution: Sterile distilled water
  • Purity: Greater than 95% by SDS-PAGE gel analyses
  • Uniprot ID: P26894
Description: Recombinant Pig protein for IL-8

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