Primary prevention of sickle cell disease

Ivan September 9, 2020 0 Comments
myasthenickids

Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective

  • For couples with sickle cell trait (SCT) who are at risk for having a child with sickle cell disease (SCD), cost is a barrier to using in vitro fertilization (IVF) with preimplantation genetic testing for monogenic diseases (PGT-M) and insurance coverage is not universal.
  • The objective of this study was to evaluate the cost-effectiveness of IVF+PGT-M for couples who both carry SCT and wish to avoid SCD in a child compared to natural conception with the possible birth of a child with SCD, and the associated lifetime medical costs and lost income. A cost-effectiveness analysis was performed with a decision analytic model. Sensitivity analyses, including Monte Carlo Simulations, assessed the impact of changes in input parameters on the incremental cost-effectiveness ratio (ICER).
  • Probabilities and cost estimates were derived from the published literature. Effectiveness was measured in life years (LY) gained. The ICER was calculated to determine the cost-effectiveness of the IVF+PGT-M intervention. Compared to natural conception, IVF+PGT-M had an effectiveness gain of 30 LY, an additional cost of $572,392.68 per individual conceived, and an ICER of $19,319 per LY gained.
  • The ICER is lower than a conservative, preset willingness to pay (WTP) threshold of $50,000 per LY gained. Monte Carlo Simulations demonstrated that, in 91% of iterations, IVF+PGT-M was cost-effective at the WTP of $50,000. IVF+PGT-M is a cost-effective strategy to avoid conceiving a child with SCD and broader insurance coverage is warranted. This article is protected by copyright. All rights reserved.
myasthenickids
myasthenickids

anti-PKA R2
YF-PA13990 50 ul
EUR 435.6
Description: Mouse polyclonal to PKA R2

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 418.8

Anti-IL-31 Antibody
A08339-1 100ug/vial
EUR 400.8

Anti-IL-17B Antibody
A10846-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for IL-17B Antibody (IL17B) detection.tested for IHC in Human, Rat.

Anti-IL-6 Antibody
A00102-1 100ug
EUR 518.4
Description: Rabbit Polyclonal IL-6 Antibody. Validated in Neu, IHC, WB and tested in Human.

Anti-TNF-R2 antibody
STJ96053 200 µl
EUR 236.4
Description: Rabbit polyclonal to TNF-R2.

Anti-GABAB R2 antibody
STJ96379 200 µl
EUR 236.4
Description: Rabbit polyclonal to GABAB R2.

Anti-MonoMethylH3R2me1-(R2) antibody
STJ24010 100 µl
EUR 471.6
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.

Anti-PKA R2 (3C7)
YF-MA14876 100 ug
EUR 435.6
Description: Mouse monoclonal to PKA R2

Anti-PKA R2 (6A9)
YF-MA10721 100 ug
EUR 435.6
Description: Mouse monoclonal to PKA R2

Anti-IL-3R beta Antibody
A02219-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for IL-3R beta Antibody (CSF2RB) detection.tested for WB in Human, Mouse, Rat.

Anti-IL-2/IL2 Antibody
A00387-1 100ug/vial
EUR 352.8

Anti-IL-8 Monoclonal Antibody
A00423-1 100ul
EUR 476.4
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat.

Anti-IL-22/IL22 Antibody
A00963-1 100ug/vial
EUR 352.8

Anti-IL-17A Monoclonal Antibody
M00421-1 100ug
EUR 546
Description: Mouse Monoclonal IL-17A Antibody. Validated in WB and tested in Human.

Anti-IL-6 Monoclonal Antibody
M00102-1 100ug
EUR 546
Description: Mouse Monoclonal IL-6 Antibody. Validated in Flow Cytometry, WB and tested in Human.

HRP-Goat Anti-Mouse Secondary Antibody
A12003
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

HRP-Goat Anti-Rabbit Secondary Antibody
A12004
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486-1mg 1 mg
EUR 1076.4

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486-5mg 5 mg
EUR 2886

Anti-Human IL-17F Biotin Conjugated Monoclonal Antibody
B02062-1 100ug
EUR 518.4
Description: Mouse Monoclonal Human IL-17F Biotin Conjugated Antibody. Validated in IHC, WB and tested in Human.

Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated
A12001
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Goat Anti-Rat Secondary Antibody, Biotin Conjugated
A12002
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

IL-1 β
E13-003-1 10μg
EUR 255.6

IL-1 α
E13-029-1 10μg
EUR 255.6

Anti-IL-32A Antibody Peroxidase Conjugated
A03286-1 100ug
EUR 546
Description: Rabbit Polyclonal IL-32A Antibody Peroxidase Conjugated. Validated in WB and tested in Human.

Anti-GABA(B) R2 Purified
11-551-C100 0.1 mg
EUR 244.8

IL-1 beta, rat recombinant
P1019-1 1 mg
EUR 8745.6
Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells. Both IL-1? and IL-1? bind to the same receptor and have similar biological properties.

IL-1beta, human recombinant
P1018-1 1 mg
EUR 6073.2
Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells

IL-2, human recombinant
P1020-1 1 mg
EUR 1387.2
Description: Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes and is produced by activated CD4+ and CD8+ T cells, gamma ? T cells, B cells, dendritic cells and eosinophils. IL-2 plays a critical role in immune responses against pathogenic infection

IL-3, human recombinant
P1021-1 1 mg
EUR 4820.4
Description: Interleukin 3 (IL-3) is a pleiotropic cytokine produced by activated T cells, mast cells and eosinophils, and stimulates the proliferation and differentiation of pluripotent hematopoietic stem cells, and committed progenitor cells of the megakaryocyte

IL-7, human recombinant
P1024-1 1 mg
EUR 8328
Description: Interleukin-7 (IL-7) is a potent lymphoid cell growth factor produced by bone marrow and thymic stromal cells, spleen cells and keratinocytes. IL7 stimulates the proliferation of Pre-B, Pro-B and early T cells.

Human Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit
EI2200-1 96 Well Plate
EUR 572.4

Human Interleukin-1-alpha (IL-1-alpha) AssayMax ELISA Kit
EI2301-1 96 Well Plate
EUR 572.4

Notoginsenoside R2
HY-N0909 10mg
EUR 555.6

Notoginsenoside R2
TN028181 20mg Ask for price

Stipuleanoside R2
TBZ1475 unit Ask for price

Human Genomic DNA 
X11000
  • Ask for price
  • EUR 235.40
  • 0.2 ml
  • 0.2 ml

Recombinant Rat IL-1 Beta Protein
PROTQ63264-1 10ug
EUR 380.4
Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues.

Canine IL-1 beta Recombinant Protein
R00101-1 5ug/vial
EUR 310.8
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Canine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Canine IL-1 alpha Recombinant Protein
R01144-1 5ug/vial
EUR 310.8
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Canine IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast.

Human Brain Genomic DNA  
X11001
  • Ask for price
  • EUR 77.00
  • 10 µg
  • 10 ul

IL-1-alpha Interleukin-1 alpha Human Recombinant Protein, His Tag
PROTP01583-1 Regular: 20ug
EUR 380.4
Description: IL-1A Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids fragment (113-271) with an amino-terminal hexahistidine tag and having a total molecular mass of 22.5kDa. ;The Interleukin-1 alpha His-tag is purified by proprietary chromatographic techniques.

IL-1-beta Interleukin-1 betaHuman Recombinant Protein
PROTP01584-1 Regular: 10ug
EUR 380.4
Description: Interleukin-1 beta Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton.;The IL-1b is purified by proprietary chromatographic techniques.

IL-10, human recombinant protein
P1028-1 1 mg
EUR 8077.2
Description: Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the synthesis of proinflammatory cytokines such as IL-1 and TNF-? and proliferation of T cells

IL-15, human recombinant protein
P1029-1 1 mg
EUR 6406.8
Description: Interleukin 15 (IL-15) is an immunomodulating cytokine mainly produced by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells and stimulates the proliferation of T lymphocytes.

IL-17A, human recombinant protein
P1030-1 1 mg
EUR 4987.2
Description: Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by Th17 cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases and stimulates the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as the production of nitric oxide (NO).

IL-18, human recombinant protein
P1032-.1 100 µg
EUR 936
Description: Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures.

IL-18, human recombinant protein
P1032-1 1 mg
EUR 6073.2
Description: Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures.

IL-21, human recombinant protein
P1033-1 1 mg
EUR 7826.4
Description: Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. IL-21 induces the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells, apoptotic effects in naïve B-cells.

Recombinant Human IL-12 Protein
PROTP29459-1 10ug
EUR 380.4
Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

Recombinant Human IL-24 Protein
PROTQ13007-1 20ug
EUR 380.4
Description: IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.

Recombinant Human IL-31 Protein
PROTQ6EBC2-1 10ug
EUR 380.4
Description: Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.

Recombinant Human IL-17D Protein
PROTQ8TAD2-1 25ug
EUR 380.4
Description: IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8, and GM-CSF and inhibits hemopoiesis of myeloid progenitor cells in colony forming assays. Recombinant human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.

Recombinant Human IL-22 Protein
PROTQ9GZX6-1 10ug
EUR 380.4
Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

Recombinant Human IL-17E Protein
PROTQ9H293-1 25ug
EUR 380.4
Description: IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 145 amino acid polypeptide chains.

Recombinant Human IL-20 Protein
PROTQ9NYY1-1 10ug
EUR 380.4
Description: IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-α and type II IL-20R-β. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.

Recombinant Human IL-19 Protein
PROTQ9UHD0-1 10ug
EUR 380.4
Description: IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-α and induces apoptosis through TNF-α. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.

Anti-Phospho-GABAB R2 (Ser783) Antibody
P03830 100ul
EUR 477.6
Description: Rabbit Polyclonal Phospho-GABAB R2 (Ser783) Antibody. Validated in IF, WB and tested in Mouse, Rat.

Recombinant Murine IL-17 (IL-17A) Protein
PROTQ62386-1 25ug
EUR 380.4
Description: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 336

IL-8 (77 a.a.), human recombinant
P1026-1 1 mg
EUR 5071.2
Description: Interleukin-8 (IL-8) is a proinflammatory CXC chemokine produced by macrophages, epithelial cells. IL-8 is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies

TNF- R2 Antibody
ABF0364 100 ug
EUR 525.6

TNF- R2 Antibody
ABF0365 100 ug
EUR 525.6

PKA R2 Antibody
DF3091 200ul
EUR 420

PKA R2 Antibody
AF6724 100ul
EUR 420

R-Notoginsenoside R2
N2244-20 20 mg
EUR 686.4
Description: Extracted from Panax Notoginseng dried roots;Store the product in sealed, cool and dry condition

ApoE R2, CF
PR15062CF 50 ug
EUR 553.2

IL-8 Interleukin-8 (1-77 a.a) Human Recombinant Protein (CXCL8)
PROTP10145-1 Regular: 25ug
EUR 380.4
Description: Interleukin-8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8904 Dalton. ;The IL-8 is purified by proprietary chromatographic techniques.

IL-1RA Interleukin-1 Receptor Antagonist Human Recombinant Protein, His Tag
PROTP18510-1 Regular: 50ug
EUR 818.4
Description: IL1Ra Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.63kDa with an amino-terminal hexahistidine tag. ;The IL-1Ra His is purified by proprietary chromatographic techniques.

Porphyromonas gingivalis Gingipain R2 (rgpB)
1-CSB-EP310587EYA
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Porphyromonas gingivalis Gingipain R2(rgpB),partial expressed in E.coli

Mouse Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit
EMI2200-1 96 Well Plate
EUR 572.4

IL-2
E13-013-1 10μg
EUR 193.2

IL-4
E13-015-1 10μg
EUR 193.2

IL-6
E13-016-1 10μg
EUR 193.2

Anti-GABAB Receptor (Ser783), R2-Subunit antibody
STJ120094 100 µl
EUR 631.2

IL-4 Interleukin-4 Human Recombinant Protein
PROTP05112-1 Regular: 20ug
EUR 380.4
Description: Interleukin-4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 15kDa. ;The IL-4 is purified by proprietary chromatographic techniques.

In vitro fertilisation with preimplantation genetictesting: the need for expanded insurance coverage

Technological advances in genetic testing have enabled prospective parents to learn about their risk of passing a genetic condition to their future children.
One option for those who want to ensure that their biological children do not inherit a genetic condition is to create embryos through in vitro fertilisation (IVF) and use a technique called preimplantation genetic testing (PGT) to screen embryos for genetic abnormalities before implantation.
Unfortunately, due to its high cost, IVF-with-PGT is out of reach for the vast majority of Americans. This article addresses an issue that has been underexplored in the medical ethics literature: the lack of insurance coverage for IVF-with-PGT.Within the US system, a key concept in insurance is that of medically necessary care, which broadly consists of diagnostic services and treatment services. In this article, I argue that IVF-with-PGT could be classified as either a diagnostic service or as a treatment service.
To make this case, I show that IVF-with-PGT is similar to other types of services that are often covered by US insurance providers. In light of these similarities, I argue that the current system is inconsistent with respect to what is-and is not-covered by insurance. To promote consistency and fairness in coverage, like cases should be treated alike-starting with greater coverage for IVF-with-PGT.

Lack of familiarity with genetictesting among patients in Ireland with Cancer

Background: Cancer gene panel testing is available in Ireland. The need for a clear strategy to deal with patient information generated from tumour genomic testing is recognised as a challenge in the National Cancer Strategy. However, the public’s attitude and opinions regarding these results is not known in Ireland.
Aims: This prospective questionnaire study assessed the knowledge and opinions of patients in a national oncology centre, surrounding cancer gene panel testing.
Methods: An anonymised modified validated questionnaire was completed by volunteering patients in the medical oncology department. It comprised 14 questions which assessed patient’s familiarity, intention, benefits and concerns associated with tumour genetic testing using a four-point Likert scale. Patients recorded their primary cancer diagnosis and family cancer history.
Results: Eighty-four patients completed the questionnaire with 77 (92%) patients declaring their primary cancer diagnosis. The median age was 56 (range 26 to 83) years. Overall, 42% (n = 35) of oncology patients were familiar/somewhat familiar with testing and 90% (n = 76) stated they would avail of genetic testing if available. Patients with breast cancer were no more likely to avail of genetic testing when compared with the non-breast cancer cohort (n = 21 vs. 56, p = 0.58) though they identified concerns with potential discrimination.
Conclusion: This is the first prospective Irish study to assess opinions surrounding cancer gene results. Addressing patient’s lack of information as regards genetic testing is the first step in establishing a national cancer genetics testing programme in Ireland.

1730 8 SNAP-SEAL 8 OZ
1730-8 100/pk
EUR 88.8
Description: Disposable Plastic; Plastic Containers

mAb mouse anti-human IL-8
CT264 0.5 mg
EUR 312

IL-8
E5-00004 1mg
EUR 1152

Anti-IL-8 Monoclonal Antibody
A00423-1 100ul
EUR 476.4
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat.

Individual Reaction Mix 8
G065-8 200 reactions
EUR 200.4

Swine IL-6 Recombinant Protein
R00102-8 5ug/vial
EUR 310.8
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Swine IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Swine IL-4 Recombinant Protein
R00230-8 5ug/vial
EUR 310.8
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Swine IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

Rabbit IL-2 Recombinant Protein
R00387-8 5ug/vial
EUR 310.8
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Rabbit IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

Swine IL-17A Recombinant Protein
R00421-8 5ug/vial
EUR 310.8
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Swine IL-17A Recombinant Protein is purified interleukin-17A produced in yeast.

Human Interleukin-8 (IL-8) Antibody
13102-05011 150 ug
EUR 248.4

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 418.8

Human IL-8 Antibody
33486-05111 150 ug
EUR 313.2

Human IL-8 Protein
abx060803-25ug 25 ug
EUR 644.4

Human IL-8 Protein
abx060804-25ug 25 ug
EUR 644.4

Recombinant Human IL-8
P0180 100ug
EUR 626.83
Description: Recombinant Human protein for IL-8

IL-8/CXCL8, Human
HY-P7224 50ug
EUR 596.4

Recombinant Human IL-8
SJB05-01 25µg/vial
EUR 342

Ovine IL-1 beta Recombinant Protein
R00101-8 5ug/vial
EUR 310.8
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Ovine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Sprint™ 8 Clinical Centrifuge with 8 x 15ml fixed angle rotor, 115V
C5000-8 1 each
EUR 537.8

Human THSD7a ELISA kit
8-E01A2155
  • EUR 1524.00
  • EUR 624.00
  • EUR 822.00
  • 192 tests
  • 1 plate of 48 wells
  • 1 plate of 96 wells
Description: A competitive ELISA for quantitative measurement of Human THSD7a in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-bovine IL-8 (CXCL8) antibody
STJ15100008 250 µg
EUR 403.2
Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot.

Anti-bovine IL-8 (CXCL8) antibody
STJ15100009 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA.

IL-8 Inhibitor
5-01378 4 x 5mg Ask for price

IL-8 Antibody
5149-100
EUR 405.6

IL-8 Antibody
BF0238 200ul
EUR 540

CXCL8/IL-8
E21-C97 10ug
EUR 411.6

CXCL8/IL-8
GT15156 100 ug
EUR 631.2

IL-8 Inhibitor
H-2268.0001 1.0mg
EUR 200.4
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

IL-8 Inhibitor
H-2268.0005 5.0mg
EUR 691.2
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

IL-8 Inhibitor
H-2268.0025 25.0mg
EUR 2648.4
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

Bovine(IL-8)
QY-E60063 96T
EUR 511.2

IL-8 Antibody
R30420 100 ug
EUR 419

IL-8 Antibody
R31932 100 ug
EUR 419

IL-8 Antibody
F51235-0.08ML 0.08 ml
EUR 165

IL-8 Antibody
F51235-0.4ML 0.4 ml
EUR 379

IL-8, Interleukin-8, monkey
RC222-19 5ug
EUR 125.26

Human Interleukin 8, IL-8 ELISA KIT
CSB-E04641h-24T 1 plate of 24 wells
EUR 198
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 8, IL-8 ELISA KIT
1-CSB-E04641h
  • EUR 600.00
  • EUR 4082.40
  • EUR 2184.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid(CSF), tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 8(IL-8)ELISA Kit
GA-E0129HM-48T 48T
EUR 346.8

Human Interleukin 8(IL-8)ELISA Kit
GA-E0129HM-96T 96T
EUR 559.2

Human Interleukin 8,IL-8 ELISA KIT
201-12-0090 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 8 (IL-8) CLIA Kit
abx195916-96tests 96 tests
EUR 990

Human Interleukin-8 (IL-8) ELISA Kit
LF-EK60006 1×96T
EUR 948

Human IL-8(Interleukin 8) ELISA Kit
EH0205 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human Interleukin 8(IL-8)ELISA Kit
QY-E04259 96T
EUR 433.2

Human IL-8 ELISA kit
CT212A 5-plate
EUR 554.4

Human IL-8 ELISA Kit
EHI0063 96Tests
EUR 625.2

Human IL-8 ELISA kit
LF-EK50165 1×96T
EUR 777.6

human IL-8 His tag
E410A07-100 100μg
EUR 1152

IL-8/CXCL8, 72a.a., Human
HY-P7380 50ug
EUR 596.4

rec Endothelial IL-8 (human)
H-3742.0010 10.0µg
EUR 340.8
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9]

rec Endothelial IL-8 (human)
H-3742.0050 50.0µg
EUR 1167.6
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9]

IL-8 (Human) ELISA Kit
K4169-100
EUR 874.8

rec Monocyte IL-8 (human)
H-9625.0005 5.0µg
EUR 194.4
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8]

rec Monocyte IL-8 (human)
H-9625.0025 25.0µg
EUR 457.2
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8]

IL-8 ELISA KIT|Human
EF003990 96 Tests
EUR 826.8

Recombinant Human IL-8 Protein
RP00052 5 μg
EUR 178.8

Bovine Cytokines IL-8(Cytokines IL-8) ELISA Kit
QY-E60102 96T
EUR 511.2

Pesticide Mix 8 Containing 15 Compounds in Acetonitrile
SPXPR-8 1ML
EUR 249.66

Horse Interleukin 8 (IL-8) ELISA
QY-E120050 96T
EUR 573.6

IL-8, CXCL8, Interleukin-8, canine
RC242-19 5ug
EUR 125.26

IL-8, CXCL8, Interleukin-8, porcine
RC282-19 5ug
EUR 125.26

Recombinant Human Interleukin-8/IL-8 (C-6His)
CC97-10ug 10ug
EUR 175.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)
CC97-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)
CC97-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)
CC97-50ug 50ug
EUR 406.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)
C035-10ug 10ug
EUR 181.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)
C035-1mg 1mg
EUR 2203.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)
C035-500ug 500ug
EUR 1557.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)
C035-50ug 50ug
EUR 424.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)
C037-10ug 10ug
EUR 181.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)
C037-1mg 1mg
EUR 2203.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)
C037-500ug 500ug
EUR 1557.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)
C037-50ug 50ug
EUR 412.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

CLIA kit for Human IL-8 (Interleukin 8)
E-CL-H0048 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human IL-8 (Interleukin 8)
E-EL-H0048 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant

Human Interleukin-8 (IL-8) AssayMax ELISA Kit
EI1008-1 96 Well Plate
EUR 572.4

ELISA kit for Human Interleukin 8,IL-8
EK0240 96 tests
EUR 723.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Interleukin 8,IL-8 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Interleukin-8 (IL-8) Antibody (Biotin Conjugate)
13102-05021 150 ug
EUR 313.2

IL-8, CXCL8, Interleukin-8 (72 a.a.), human
RC212-19A 5ug
EUR 125.26

IL-8, CXCL8, Interleukin-8 (77 a.a.), human
RC212-19B 5ug
EUR 125.26

8 mm Crimp head ; Level 3 High Performance Applications
ECMJ-8 EACH
EUR 295.26

Genorise® Biotinylated Anti-Human IL-8 Polyclonal Antibody
GR109009 50 mg
EUR 477.6

IL-8 Polyclonal Antibody
ABP52884-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody
ABP52884-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody
ABP52884-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody
ES2620-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES2620-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES3883-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES3883-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES5885-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for IHC, WB, ELISA

IL-8 Polyclonal Antibody
ES5885-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for IHC, WB, ELISA

IL-8 Recombinant Protein
40-331-0005mg 0.005 mg
EUR 311.1
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

IL-8 Recombinant Protein
40-331-0025mg 0.025 mg
EUR 437.1
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

IL-8 Recombinant Protein
91-026 0.05 mg
EUR 651.3
Description: Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.

IL-8 Recombinant Protein
91-028 0.05 mg
EUR 619.8
Description: Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.

IL-8 Polyclonal Antibody
41063-100ul 100ul
EUR 302.4

IL-8 Polyclonal Antibody
41063-50ul 50ul
EUR 224.4

IL-8 Polyclonal Antibody
ABP54886-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP54886-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP54886-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP51621-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP51621-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody
ABP51621-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Recombinant Protein
90-492 10 ug
EUR 405.6
Description: Interleukin-8 (IL-8) was originally discovered as a neutrophil chemotactic and activating factor and is a member of the alpha (CXC) subfamily of chemokines (including also platelet factor 4, GRO, IP-10, etc.). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes and various tumor cell lines, produce IL-8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS and viruses. IL-8 has a wide range of other proinflammatory effects. It is a potent chemoattractant for neutrophils and causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both in vivo and in vitro.

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