A 2020 update on the use of genetic testing for patients

A 2020 update on the use of genetic testing for patients with primary immunodeficiency
- Introduction: Genetic testing of patients with clinically diagnosed or suspected primary immunodeficiencies (PIDs) constitutes standard of care. Choice of testing modality and patient attributes can impact the likelihood of securing a diagnosis.
- Areas covered: Published diagnostic rates for gene panel testing, exome sequencing (WES), and whole genome sequencing are compared among cohorts identified within PubMed. Performance of the testing platforms is reviewed in PIDs taken as a whole, followed by separate cohorts of patients with suspected PIDs, specific PIDs, and clinical phenotypes that can be associated with underlying PIDs.
- Expert opinion: Massively parallel high throughput sequencing clearly represents the most expedient method for diagnosis of PIDs. For patients from highly consanguineous backgrounds, WES and whole genome sequencing should be performed to obtain optimal diagnostic yield. For patients for whom familial consanguinity is unlikely, choice of platform depends upon the phenotype. In patients with suspected PIDs, assessment for copy number variants is important, whether as part of gene panel bioinformatic analyses or combined with WES.
- Diagnostic rates overall for massively parallel sequencing are high for clinically diagnosed and suspected PIDs. WES may have a slightly higher overall yield, but gene panel testing represents a cost effective and efficient reasonable initial step.

GRO1/KC Mouse Recombinant Protein (CXCL1) |
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PROTP12850-1 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: KC Mouse Recombinant also known as N51 and GRO1 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of approximately 8 kDa.;The GRO-1 is purified by proprietary chromatographic techniques. |
Recombinant Mouse (E.Coli) GRO/KC (CXCL1) |
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RP-1037 | Alpha Diagnostics | 5 ug | EUR 196.8 |
Recombinant Murine KC (CXCL1) Protein |
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PROTP12850-2 | BosterBio | 20ug | EUR 380.4 |
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
GRO, KC, CXCL1, rRtGRO, rat |
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RC352-12 | Bio Basic | 5ug | EUR 125.26 |
GRO/KC (CXCL1), Rat Recombinant |
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P1288-25 | Biovision | each | EUR 444 |
GRO/KC (CXCL1), Rat Recombinant |
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P1288-5 | Biovision | each | EUR 210 |
GRO1/KC Mouse, GRO/KC (CXCL1) Mouse Recombinant Protein, His Tag |
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PROTP12850 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: GRO1/KC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids (25-96 a.a.) and having a molecular mass of 10.5kDa.;GRO1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
GRO-alpha, KC, CXCL1 (rMuKC), murine (mouse) |
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RC332-12 | Bio Basic | 5ug | EUR 125.26 |
Recombinant Rat GRO/KC (CXCL1) Protein |
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PROTP14095-1 | BosterBio | 25ug | EUR 380.4 |
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
Rat CXCL1/CINC-1/KC ELISA Kit |
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RK00196 | Abclonal | 96 Tests | EUR 625.2 |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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YLA0122MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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YLA0122MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
KC protein (Mouse) |
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30R-AK001 | Fitzgerald | 20 ug | EUR 327.6 |
Description: Purified recombinant Mouse KC protein |
Anti-CXCL1 antibody |
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STJ28366 | St John's Laboratory | 100 µl | EUR 332.4 |
Description: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. |
Anti-CXCL1 antibody |
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STJ72026 | St John's Laboratory | 100 µg | EUR 312 |
Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
KC antibody |
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70R-12297 | Fitzgerald | 100 ug | EUR 632.4 |
Description: Rabbit polyclonal KC antibody |
KC antibody |
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70R-12298 | Fitzgerald | 100 ug | EUR 590.4 |
Description: Rabbit polyclonal KC antibody |
KC antibody |
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20R-1786 | Fitzgerald | 100 ug | EUR 781.2 |
Description: Rabbit polyclonal KC antibody |
KC antibody |
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70R-KR006 | Fitzgerald | 50 ug | EUR 327.6 |
Description: Affinity purified Rabbit polyclonal KC antibody |
KC Antibody |
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5211-100 | Biovision | each | EUR 451.2 |
KC Antibody |
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5212-100 | Biovision | each | EUR 470.4 |
KC Antibody |
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5212-30T | Biovision | each | EUR 175.2 |
Rabbit Anti Mouse Cxcl1 Polyclonal Antibody |
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CPBT-65100RM | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
anti-7-ketocholesterol (7-KC) (35A) |
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LF-MA90006 | Abfrontier | 20 ug | EUR 1230 |
Description: Mouse monoclonal to 7-ketocholesterol (7-KC) |
anti-7-ketocholesterol (7-KC) (35A) |
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LF-MA90007 | Abfrontier | 100 ug | EUR 3270 |
Description: Mouse monoclonal to 7-ketocholesterol (7-KC) |
KC Blocking Peptide |
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33R-11041 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KC antibody, catalog no. 70R-12298 |
KC Recombinant Protein |
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40-339-0005mg | ProSci | 0.005 mg | EUR 311.1 |
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
KC Recombinant Protein |
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40-339-002mg | ProSci | 0.02 mg | EUR 437.1 |
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
KC 12291 hydrochloride |
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B7332-10 | ApexBio | 10 mg | EUR 447.6 |
KC 12291 hydrochloride |
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B7332-50 | ApexBio | 50 mg | EUR 1635.6 |
Polyclonal KC Antibody |
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APR16969G | Leading Biology | 0.1mg | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human KC . This antibody is tested and proven to work in the following applications: |
KC Blocking Peptide |
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5212BP-50 | Biovision | each | EUR 183.6 |
Mouse CXCL1 ELISA Kit |
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55R-1741 | Fitzgerald | 1 kit | EUR 748.8 |
Description: ELISA kit for detection of CXCL1 in the research laboratory |
Mouse CXCL1 shRNA Plasmid |
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20-abx970673 | Abbexa |
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GRO-alpha/CXCL1, Mouse |
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HY-P7188 | MedChemExpress | 50ug | EUR 639.6 |
Anti-GRO alpha/Cxcl1 Antibody |
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A00533 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-GRO alpha/CXCL1 Antibody |
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PA1760 | BosterBio | 100ug/vial | EUR 352.8 |
KiloGreen 2X qPCR MasterMix-iCycler |
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MasterMix-KC | ABM | 4 x 1.25 ml - 500 reactions (20 ul) | EUR 168 |
Mouse keinocyte chemoattractant (KC) ELISA kit |
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E03K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Mouse keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse keinocyte chemoattractant (KC) ELISA kit |
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E03K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Mouse keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse keinocyte chemoattractant (KC) ELISA kit |
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E03K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Mouse keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
CXCL1 antibody |
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70R-10502 | Fitzgerald | 50 ug | EUR 560.4 |
Description: Affinity purified rabbit polyclonal CXCL1 antibody |
CXCL1 Antibody |
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43679-100ul | SAB | 100ul | EUR 302.4 |
CXCL1 antibody |
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70R-16681 | Fitzgerald | 50 ul | EUR 522 |
Description: Rabbit polyclonal CXCL1 antibody |
CXCL1 antibody |
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70R-14297 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Affinity purified Rabbit polyclonal CXCL1 antibody |
CXCL1 antibody |
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70R-15473 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal CXCL1 antibody |
CXCL1 protein |
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30R-3156 | Fitzgerald | 50 ug | EUR 308.4 |
Description: Purified recombinant CXCL1 protein |
CXCL1 Peptide |
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42-129P | ProSci | 0.1 mg | EUR 405.6 |
Description: (CT) CXCL1 Peptide |
CXCL1 Antibody |
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33054-100ul | SAB | 100ul | EUR 302.4 |
CXCL1 siRNA |
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20-abx901350 | Abbexa |
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CXCL1 siRNA |
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20-abx913248 | Abbexa |
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CXCL1 siRNA |
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20-abx913249 | Abbexa |
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Cxcl1 Antibody |
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1-CSB-PA09217A0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL1 Antibody |
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1-CSB-PA06097A0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL1 Antibody |
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1-CSB-PA006239GA01HU | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
CXCL1 Antibody |
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1-CSB-PA009036 | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
CXCL1/GRO |
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EF012822 | Lifescience Market | 96 Tests | EUR 826.8 |
CXCL1/GRO |
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E21-597 | EnoGene | 10ug | EUR 411.6 |
pEGFP- CXCL1 |
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PVT10178 | Lifescience Market | 2 ug | EUR 361.2 |
Polyclonal Goat anti-GST α-form |
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GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
KC Kimtech precision wipes |
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CLE7552 | Scientific Laboratory Supplies | PK30 | EUR 209.76 |
KC Delicate Task Wipes |
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CLE7558 | Scientific Laboratory Supplies | PK15 | EUR 126.54 |
GRO/KC, murine recombinant |
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4210-100 | Biovision | each | EUR 927.6 |
GRO/KC, murine recombinant |
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4210-1000 | Biovision | each | EUR 4627.2 |
GRO/KC, murine recombinant |
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4210-20 | Biovision | each | EUR 307.2 |
Rabbit Anti Rat Cxcl1 Polyclonal Antibody |
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CPBT-65101RR | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Mouse CXCL1 Detection Assay Kit |
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6725 | Chondrex | 1 kit | EUR 580.26 |
Description: Mouse CXCL1 Detection Assay Kit |
CXCL1 protein (Mouse) (His tag) |
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80R-3368 | Fitzgerald | 50 ug | EUR 308.4 |
Description: Purified recombinant CXCL1 protein (Mouse) (His tag) |
CXCL1 protein (Mouse) (His tag) |
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80R-3439 | Fitzgerald | 50 ug | EUR 308.4 |
Description: Purified recombinant CXCL1 protein (Mouse) (His tag) |
CXCL1 ELISA Kit (Mouse) (OKBB00312) |
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OKBB00312 | Aviva Systems Biology | 96 Tests | EUR 652.8 |
Description: Description of target: Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. The mature form of CXCL1 is maximally 73 amino acids long. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function. The standard product used in this kit is recombinant mouse CXCL1, consisting of 77 amino acids with the molecular mass of 8KDa.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/ml |
Mouse CXCL1 PicoKine ELISA Kit |
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EK0723 | BosterBio | 96 wells | EUR 547.2 |
Description: For quantitative detection of mouse CXCL1 in cell culture supernates and serum. |
CXCL1 ELISA Kit (Mouse) (OKAN04583) |
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OKAN04583 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.0 pg/mL |
CXCL1 ELISA Kit (Mouse) (OKCD05712) |
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OKCD05712 | Aviva Systems Biology | 96 Wells | EUR 730.8 |
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.0pg/mL |
Cxcl1 ORF Vector (Mouse) (pORF) |
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ORF042286 | ABM | 1.0 ug DNA | EUR 114 |
ELISA kit for Mouse CXCL1 |
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EK5299 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse CXCL1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
Mouse CXCL1/GROα ELISA kit |
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LF-EK50473 | Abfrontier | 1×96T | EUR 777.6 |
KC ELISA Kit (Mouse) : 96 Wells (OKAG00090) |
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OKAG00090 | Aviva Systems Biology | 96 Wells | EUR 715.2 |
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 8 pg/mL |
CXCL1 antibody (HRP) |
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60R-2236 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal CXCL1 antibody (HRP) |
CXCL1 antibody (FITC) |
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60R-2237 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal CXCL1 antibody (FITC) |
CXCL1 antibody (biotin) |
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60R-2238 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal CXCL1 antibody (biotin) |
CXCL1 Blocking Peptide |
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33R-7741 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CXCL1 antibody, catalog no. 70R-10502 |
CXCL1 Recombinant Protein |
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91-532 | ProSci | 0.05 mg | EUR 714.3 |
Description: Chemokine (C-X-C motif) Ligand 1 Protein (CXCL1) is a growth factor for melanoma cells and a chemotaxin for neutrophils and a member of the CXC chemokine family that is a potent neutrophil attractant and activator and is also active toward basophils. CXCL1 is expressed by macrophages, neutrophils and epithelial cells; it has neutrophil chemoattractant activity. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection and may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. |
CXCL1 Recombinant Protein |
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91-628 | ProSci | 0.05 mg | EUR 651.3 |
Description: Cxcl1, also called Gro, Gro1, Mgsa or Scyb1, is short for growth-regulated alpha protein. The protein belongs to the intercrine alpha (chemokine CxC) family. The N-terminal processed form KC(5-72) of the protein is produced by proteolytic cleavage after secretion from bone marrow stromal cells, and shows a highly enhanced hematopoietic activity. Cxcl1 has chemotactic activity for neutrophils, and contributes to neutrophil activation during inflammation. Hematoregulatory chemokine, in vitro, suppresses hematopoietic progenitor cell proliferation. |
CXCL1 Blocking Peptide |
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20-abx061039 | Abbexa |
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CXCL1 Conjugated Antibody |
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C33054 | SAB | 100ul | EUR 476.4 |
CXCL1 cloning plasmid |
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CSB-CL006239HU-10ug | Cusabio | 10ug | EUR 279.6 |
Description: A cloning plasmid for the CXCL1 gene. |
Recombinant Human CXCL1 |
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P0109 | FN Test | 100ug | EUR 626.83 |
Description: Recombinant Human protein for CXCL1 |
Recombinant Human CXCL1 |
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P0207 | FN Test | 100ug | EUR 626.83 |
Description: Recombinant Human protein for CXCL1 |
pCMV-SPORT6-CXCL1 |
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PVT13291 | Lifescience Market | 2 ug | EUR 469.2 |
Cxcl1 Polyclonal Antibody |
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A51950-020 | EpiGentek | 20 ul | EUR 117.7 |
Cxcl1 Polyclonal Antibody |
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A51950-050 | EpiGentek | 50 ul | EUR 302.5 |
Cxcl1 Polyclonal Antibody |
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A51950-100 | EpiGentek | 100 ul | EUR 423.5 |
CXCL1 Polyclonal Antibody |
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A51978-020 | EpiGentek | 20 ul | EUR 117.7 |
Breast cancer (BRCA) genetesting in ovarian cancer
The discovery of cancer-causing BRCA1/2 mutations and the emergence of genetic testing have brought precision in patient selection for poly-(ADP)-ribose polymerase inhibitor (PARPi) treatment. Interestingly, patients who are carriers of BRCA1/2 mutations have a higher risk for developing cancer, but respond better to DNA-damaging cytotoxic therapy, such as platinum-based chemotherapy.
The distinctive biology of ovarian cancer involves high genomic instability consisting of gene amplification, gene deletion, oncogene hypomethylation, loss of heterozygosity, and tumor suppressor gene promoter hypermethylation in many of the DNA damage response (DDR) genes, including BRCA1/2. Several of these genetic abnormalities can impair high fidelity DNA damage repair increasing the therapeutic audience for PARPi’s. This is especially important given the clinical development over the last decade of this group of agents and the dramatic increase in progression free survival among ovarian cancer patients who received PARPi, both in treatment or maintenance setting. In this review, we summarize our current understanding of the role of BRCA1/2 mutations in ovarian cancer and present relevant clinical trials in which BRCA1/2 was investigated as biomarker for therapy. We also outline the role of homologous recombination (HR) deficiency as biomarker by presenting the recent clinical development and recent approvals PARPi for firstline maintenance in ovarian cancer.
Haplotyping by linked-read sequencing (HLRS) of the genetic disease carriers for preimplantation genetictesting without a proband or relatives
Background: In order to mitigate the risk of allele dropout (ADO) and ensure the accuracy of preimplantation genetic testing for monogenic disease (PGT-M), it is necessary to construct parental haplotypes. Typically, haplotype resolution is obtained by genotyping multiple polymorphic markers in both parents and a proband or a relative. Sometimes, single sperm typing, or tests on the polar bodies may also be useful. Nevertheless, this process is time-consuming. At present, there was no simple linkage analysis strategy for patients without affected relatives.
Method: To solve this problem, we established a haplotyping by linked-read sequencing (HLRS) method without the requirement for additional relatives. First, the haplotype of the genetic disease carriers in the family was constructed by linked-read sequencing, and then the informative single nucleotide polymorphisms (SNPs) in upstream and downstream mutation region were selected to construct the embryo haplotype and to determine whether the embryo was carrying the mutation. Two families were selected to validate this method; one with alpha thalassemia and the other with NDP gene disorder.
Results: The haplotyping by linked-read sequencing (HLRS) method was successfully applied to construct parental haplotypes without recruiting additional family members; the method was also validated for PGT-M. The mutation carriers in these families were sequenced by linked-read sequencing, and their haplotypes were successfully phased. Adjacent SNPs of the mutation gene were identified.
The informative SNPs were chosen for linkage analyses to identify the carrier embryos. For the alpha thalassemia family, a normal blastocyst was transferred to the uterus and the accuracy of PGT-M was confirmed by amniocentesis at 16 weeks of gestation.
Conclusions: Our results suggest that HLRS can be applied for PGT-M of monogenic disorders or de novo mutations where the mutations haplotype cannot be determined due to absence of affected relatives.
Anti-CD163 |
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DB-045-0.5 | DB Biotech | 500 μl | EUR 460.8 |
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated |
Anti-CD163 |
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DB-045-1 | DB Biotech | 1 ml | EUR 735.6 |
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated |
Anti-CD163 |
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DB-045-RTU-15 | DB Biotech | 15 ml | EUR 424.8 |
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use) |
Anti-CD163 |
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DB-045-RTU-7 | DB Biotech | 7 ml | EUR 277.2 |
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use) |
Anti-CD163 |
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DB045RTU-15 | DB Biotech | 15 ml | EUR 424.8 |
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use) |
Anti-CD163 |
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DB045RTU-7 | DB Biotech | 7 ml | EUR 277.2 |
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use) |
Mouse Cluster Of Differentiation (CD163) ELISA Kit |
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DLR-CD163-Mu-48T | DL Develop | 48T | EUR 609.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cluster Of Differentiation (CD163) in samples from serum, plasma or other biological fluids. |
Mouse Cluster Of Differentiation (CD163) ELISA Kit |
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DLR-CD163-Mu-96T | DL Develop | 96T | EUR 793.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cluster Of Differentiation (CD163) in samples from serum, plasma or other biological fluids. |
Rat Cluster Of Differentiation (CD163) ELISA Kit |
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DLR-CD163-Ra-48T | DL Develop | 48T | EUR 609.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation (CD163) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Rat Cluster Of Differentiation (CD163) ELISA Kit |
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DLR-CD163-Ra-96T | DL Develop | 96T | EUR 793.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation (CD163) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Mouse Cluster Of Differentiation (CD163) ELISA Kit |
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RD-CD163-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Mouse Cluster Of Differentiation (CD163) ELISA Kit |
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RD-CD163-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Rat Cluster Of Differentiation (CD163) ELISA Kit |
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RD-CD163-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Rat Cluster Of Differentiation (CD163) ELISA Kit |
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RD-CD163-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Mouse Cluster Of Differentiation (CD163) ELISA Kit |
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RDR-CD163-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Mouse Cluster Of Differentiation (CD163) ELISA Kit |
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RDR-CD163-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Rat Cluster Of Differentiation (CD163) ELISA Kit |
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RDR-CD163-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Rat Cluster Of Differentiation (CD163) ELISA Kit |
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RDR-CD163-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
Anti-CD163 Antibody |
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A00812-1 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-CD163 Antibody |
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PA1874 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-CD163 Antibody |
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PA1874-1 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-CD163 antibody |
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STJ110681 | St John's Laboratory | 100 µl | EUR 332.4 |
Description: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Anti-CD163 Antibody |
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STJ500423 | St John's Laboratory | 100 µg | EUR 571.2 |
Anti-CD163 Antibody |
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STJ500424 | St John's Laboratory | 100 µg | EUR 571.2 |
Anti-CD163 antibody |
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STJ160082 | St John's Laboratory | 1 mL C | EUR 1129.2 |
Anti-CD163 antibody |
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STJ16100302 | St John's Laboratory | 100 µg | EUR 864 |
Anti-CD163 antibody |
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STJ16100324 | St John's Laboratory | 1 mL | EUR 1174.8 |
Anti-CD163 antibody |
|||
STJ180301 | St John's Laboratory | 0.1 ml | EUR 258 |
Anti-CD163 antibody |
|||
STJ190009 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Unconjugated Mouse monoclonal to CD163 (AS1A1) |
Anti-Hu CD163 Purified |
|||
11-645-C025 | ExBio | 0.025 mg | EUR 118.8 |
Anti-Hu CD163 Purified |
|||
11-645-C100 | ExBio | 0.1 mg | EUR 189.6 |
Anti-CD163/M130 Antibody |
|||
A00812 | BosterBio | 100ul | EUR 476.4 |
Description: Rabbit IgG polyclonal antibody for Scavenger receptor cysteine-rich type 1 protein M130 (CD163) detection.tested for IF, IHC, WB in Human, Mouse, Rat. Various direct flourescent conjugates are available for FCM upon request. Please contact us for details. |
Anti-Hu CD163 APC |
|||
1A-645-T025 | ExBio | 25 tests | EUR 168 |
Anti-Hu CD163 APC |
|||
1A-645-T100 | ExBio | 100 tests | EUR 288 |
Anti-Hu CD163 PE |
|||
1P-645-T025 | ExBio | 25 tests | EUR 168 |
Anti-Hu CD163 PE |
|||
1P-645-T100 | ExBio | 100 tests | EUR 288 |
Anti-CD163/M130 antibody |
|||
PAab09771 | Lifescience Market | 100 ug | EUR 426 |
anti- CD163/M130 Antibody |
|||
FNab09771 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against CD163/M130 |
Anti-CD163 Antibody BIOTIN |
|||
STJ500425 | St John's Laboratory | 100 µg | EUR 703.2 |
Anti-CD163 Antibody FITC |
|||
STJ500426 | St John's Laboratory | 100 µg | EUR 703.2 |
Anti-CD163 Antibody BIOTIN |
|||
STJ500427 | St John's Laboratory | 100 µg | EUR 703.2 |
Anti-CD163 Antibody FITC |
|||
STJ500428 | St John's Laboratory | 100 µg | EUR 703.2 |
human CD163 antigen,CD163 LISA kit |
|||
201-12-0247 | SunredBio | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human CD163 antigen(CD163)ISA kit |
|||
GA-E0263HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human CD163 antigen(CD163)ISA kit |
|||
GA-E0263HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human CD163 antigen(CD163)ISA kit |
|||
QY-E05066 | Qayee Biotechnology | 96T | EUR 433.2 |
human CD163 antigen,CD163 ELISA kit |
|||
YLA0098HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
human CD163 antigen,CD163 ELISA kit |
|||
YLA0098HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
Mouse Anti Human Cd163 Monoclonal Antibody |
|||
CABT-47162MH | Creative Diagnostics | 25 µg | EUR 446.4 |
Mouse Anti Human Cd163 Monoclonal Antibody |
|||
CABT-47163MH | Creative Diagnostics | 0.2 mg | EUR 1057.2 |
Polyclonal Goat anti-GST α-form |
|||
GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
|||
GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
|||
GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
Anti-CD163 Rabbit Monoclonal Antibody |
|||
M00812 | BosterBio | 100ug/vial | EUR 476.4 |
Description: Rabbit Monoclonal CD163 Antibody. Validated in IP, WB and tested in Human. |
Anti-Hu CD163 PE-Cy7 |
|||
T7-645-T025 | ExBio | 25 tests | EUR 184.8 |
Anti-Hu CD163 PE-Cy7 |
|||
T7-645-T100 | ExBio | 100 tests | EUR 321.6 |
Anti-Hu CD163 PerCP-Cy5.5 |
|||
T9-645-T025 | ExBio | 25 tests | EUR 235.2 |
Anti-Hu CD163 PerCP-Cy5.5 |
|||
T9-645-T100 | ExBio | 100 tests | EUR 422.4 |
Purified Anti-human CD163 Antibody *GHI/61* |
|||
11630000 | AAT Bioquest | 100 ug | EUR 365 |
APC Anti-human CD163 Antibody *GHI/61* |
|||
116301B0 | AAT Bioquest | 25 tests | EUR 383 |
APC Anti-human CD163 Antibody *GHI/61* |
|||
116301B1 | AAT Bioquest | 100 tests | EUR 995 |
APC Anti-human CD163 Antibody *GHI/61* |
|||
116301B2 | AAT Bioquest | 500 tests | EUR 2984 |
FITC Anti-human CD163 Antibody *GHI/61* |
|||
116301G0 | AAT Bioquest | 100 tests | EUR 547 |
FITC Anti-human CD163 Antibody *GHI/61* |
|||
116301G1 | AAT Bioquest | 500 tests | EUR 2051 |
TRITC Anti-human CD163 Antibody *GHI/61* |
|||
116301H0 | AAT Bioquest | 100 tests | EUR 547 |
TRITC Anti-human CD163 Antibody *GHI/61* |
|||
116301H1 | AAT Bioquest | 500 tests | EUR 2051 |
PacBlue Anti-human CD163 Antibody *GHI/61* |
|||
116301I0 | AAT Bioquest | 100 tests | EUR 547 |
PacBlue Anti-human CD163 Antibody *GHI/61* |
|||
116301I1 | AAT Bioquest | 500 tests | EUR 2051 |
PacOrange Anti-human CD163 Antibody *GHI/61* |
|||
116301J0 | AAT Bioquest | 100 tests | EUR 547 |
PacOrange Anti-human CD163 Antibody *GHI/61* |
|||
116301J1 | AAT Bioquest | 500 tests | EUR 2051 |
PE Anti-human CD163 Antibody *GHI/61* |
|||
116301K0 | AAT Bioquest | 25 tests | EUR 383 |
PE Anti-human CD163 Antibody *GHI/61* |
|||
116301K1 | AAT Bioquest | 100 tests | EUR 995 |
PE Anti-human CD163 Antibody *GHI/61* |
|||
116301K2 | AAT Bioquest | 500 tests | EUR 2984 |
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
116301S0 | AAT Bioquest | 25 tests | EUR 383 |
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
116301S1 | AAT Bioquest | 100 tests | EUR 995 |
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
116301S2 | AAT Bioquest | 500 tests | EUR 2984 |
Porcine CD163 antigen,CD163 LISA kit |
|||
GA-E0045PC-48T | GenAsia Biotech | 48T | EUR 436.8 |
Porcine CD163 antigen,CD163 LISA kit |
|||
GA-E0045PC-96T | GenAsia Biotech | 96T | EUR 708 |
Canine CD163 antigen(CD163 LISA kit |
|||
GA-E0062CN-48T | GenAsia Biotech | 48T | EUR 482.4 |
Canine CD163 antigen(CD163 LISA kit |
|||
GA-E0062CN-96T | GenAsia Biotech | 96T | EUR 820.8 |
Porcine CD163 antigen,CD163 LISA kit |
|||
YLA0139PO-48T | Shanghai YL Biotech | 48T | EUR 502.5 |
Porcine CD163 antigen,CD163 LISA kit |
|||
YLA0139PO-96T | Shanghai YL Biotech | 96T | EUR 618.75 |
CD163 Antibody |
|||
49553-100ul | SAB | 100ul | EUR 399.6 |
CD163 Antibody |
|||
49553-50ul | SAB | 50ul | EUR 286.8 |
CD163 Antibody |
|||
37157-100ul | SAB | 100ul | EUR 302.4 |
CD163 antibody |
|||
10R-6496 | Fitzgerald | 100 ug | EUR 243.6 |
Description: Mouse monoclonal CD163 antibody |
CD163 antibody |
|||
10R-CD163aRT | Fitzgerald | 250 ug | EUR 859.2 |
Description: Mouse monoclonal CD163 antibody |
CD163 Antibody |
|||
ABD8235 | Lifescience Market | 100 ug | EUR 525.6 |
CD163 Antibody |
|||
20-abx242956 | Abbexa |
|
|
CD163 siRNA |
|||
20-abx910930 | Abbexa |
|
|
CD163 siRNA |
|||
20-abx910931 | Abbexa |
|
|
CD163 Antibody |
|||
1-CSB-PA801238LA01HU | Cusabio |
|
|
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200 |
Cd163 Antibody |
|||
1-CSB-PA650452LA01MO | Cusabio |
|
|
Description: A polyclonal antibody against Cd163. Recognizes Cd163 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000 |
CD163 Antibody |
|||
1-CSB-PA969205 | Cusabio |
|
|
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100 |
CD163 Antibody |
|||
DF8235 | Affbiotech | 200ul | EUR 420 |
CD163 Antibody |
|||
R30973 | NSJ Bioreagents | 100 ug | EUR 419 |
CD163 Antibody |
|||
R30974 | NSJ Bioreagents | 100 ug | EUR 419 |
CD163 Antibody |
|||
RQ4259 | NSJ Bioreagents | 100 ug | EUR 419 |
CD163 Antibody |
|||
F50316-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
CD163 Antibody |
|||
F50316-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
CD163 Antibody |
|||
V8227-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V8227-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V8227SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V8415-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V8415-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V8415SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V8757-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
CD163 Antibody |
|||
V8757-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
CD163 Antibody |
|||
V8757SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
CD163 Antibody |
|||
V3937-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V3937-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V3937SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V7470-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V7470-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V7470IHC-7ML | NSJ Bioreagents | 7 ml | EUR 499 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
|||
V7470SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
Human CD163 shRNA Plasmid |
|||
20-abx956176 | Abbexa |
|
|
Human CD163 ELISA Kit |
|||
LF-EK50890 | Abfrontier | 1×96T | EUR 777.6 |
Human CD163 ELISA Kit |
|||
ELA-E1726h | Lifescience Market | 96 Tests | EUR 988.8 |
Mouse Anti Rat Cd163 Monoclonal Antibody |
|||
DMABT-47170MR | Creative Diagnostics | 0.25 mg | EUR 889.2 |
Mouse Anti Rat Cd163 Monoclonal Antibody |
|||
DMABT-47171MR | Creative Diagnostics | 0.1 mg | EUR 670.8 |
Anti-Human CD163 DyLight® 488 conjugated Antibody |
|||
A00812-Dyl488 | BosterBio | 100ug/vial | EUR 412.8 |
Anti-Human CD163 DyLight® 550 conjugated Antibody |
|||
A00812-Dyl550 | BosterBio | 100ug/vial | EUR 412.8 |
Mouse Anti-Human CD163 monoclonal antibody, clone JID274 |
|||
CABT-L2938-100uL500uL | Creative Diagnostics | 100 uL, 500 uL | EUR 602.4 |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
116301C0 | AAT Bioquest | 25 tests | EUR 429 |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
116301C1 | AAT Bioquest | 100 tests | EUR 1117 |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
116301C2 | AAT Bioquest | 500 tests | EUR 3351 |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
|||
116301L0 | AAT Bioquest | 25 tests | EUR 429 |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
|||
116301L1 | AAT Bioquest | 100 tests | EUR 1117 |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
|||
116301L2 | AAT Bioquest | 500 tests | EUR 3351 |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
116301M0 | AAT Bioquest | 25 tests | EUR 429 |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
116301M1 | AAT Bioquest | 100 tests | EUR 1117 |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
116301M2 | AAT Bioquest | 500 tests | EUR 3351 |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
|||
116301T0 | AAT Bioquest | 25 tests | EUR 429 |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
|||
116301T1 | AAT Bioquest | 100 tests | EUR 1117 |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
|||
116301T2 | AAT Bioquest | 500 tests | EUR 3351 |
Human CellExp? CD163, Human recombinant |
|||
9226-10 | Biovision | each | EUR 366 |
Human CellExp? CD163, Human recombinant |
|||
9226-50 | Biovision | each | EUR 927.6 |
iFluor® 350 Anti-human CD163 Antibody *GHI/61* |
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11630010 | AAT Bioquest | 100 tests | EUR 547 |
iFluor® 350 Anti-human CD163 Antibody *GHI/61* |
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11630011 | AAT Bioquest | 500 tests | EUR 2051 |
iFluor® 405 Anti-human CD163 Antibody *GHI/61* |
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11630020 | AAT Bioquest | 100 tests | EUR 547 |