A 2020 update on the use of genetic testing for patients
A 2020 update on the use of genetic testing for patients with primary immunodeficiency
- Introduction: Genetic testing of patients with clinically diagnosed or suspected primary immunodeficiencies (PIDs) constitutes standard of care. Choice of testing modality and patient attributes can impact the likelihood of securing a diagnosis.
- Areas covered: Published diagnostic rates for gene panel testing, exome sequencing (WES), and whole genome sequencing are compared among cohorts identified within PubMed. Performance of the testing platforms is reviewed in PIDs taken as a whole, followed by separate cohorts of patients with suspected PIDs, specific PIDs, and clinical phenotypes that can be associated with underlying PIDs.
- Expert opinion: Massively parallel high throughput sequencing clearly represents the most expedient method for diagnosis of PIDs. For patients from highly consanguineous backgrounds, WES and whole genome sequencing should be performed to obtain optimal diagnostic yield. For patients for whom familial consanguinity is unlikely, choice of platform depends upon the phenotype. In patients with suspected PIDs, assessment for copy number variants is important, whether as part of gene panel bioinformatic analyses or combined with WES.
- Diagnostic rates overall for massively parallel sequencing are high for clinically diagnosed and suspected PIDs. WES may have a slightly higher overall yield, but gene panel testing represents a cost effective and efficient reasonable initial step.
GRO1/KC Mouse, GRO/KC (CXCL1) Mouse Recombinant Protein, His Tag |
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| PROTP12850 | BosterBio | Regular: 20ug | EUR 380.4 |
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Description: GRO1/KC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids (25-96 a.a.) and having a molecular mass of 10.5kDa.;GRO1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
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GRO-alpha, KC, CXCL1 (rMuKC), murine (mouse) |
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| RC332-12 | Bio Basic | 5ug | EUR 125.26 |
GRO / KC (CXCL1) Protein |
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| 20-abx260684 | Abbexa |
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GRO / KC (CXCL1) Protein |
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| 20-abx261870 | Abbexa |
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GRO, KC, CXCL1, rRtGRO, rat |
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| RC352-12 | Bio Basic | 5ug | EUR 125.26 |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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| YLA0122MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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| YLA0122MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
GRO/KC (CXCL1), Rat Recombinant |
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| P1288-25 | Biovision | each | EUR 444 |
GRO/KC (CXCL1), Rat Recombinant |
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| P1288-5 | Biovision | each | EUR 210 |
Recombinant Murine KC (CXCL1) Protein |
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| PROTP12850-2 | BosterBio | 20ug | EUR 380.4 |
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Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Recombinant Rat GRO/KC (CXCL1) Protein |
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| PROTP14095-1 | BosterBio | 25ug | EUR 380.4 |
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Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Rat CXCL1/CINC-1/KC ELISA Kit |
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| RK00196 | Abclonal | 96 Tests | EUR 625.2 |
Rabbit Anti Mouse Cxcl1 Polyclonal Antibody |
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| CPBT-65100RM | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Mouse CXCL1 ELISA Kit |
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| 55R-1741 | Fitzgerald | 1 kit | EUR 748.8 |
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Description: ELISA kit for detection of CXCL1 in the research laboratory |
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Mouse CXCL1 shRNA Plasmid |
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| 20-abx970673 | Abbexa |
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GRO-alpha/CXCL1, Mouse |
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| HY-P7188 | MedChemExpress | 50ug | EUR 639.6 |
ELISA kit for Mouse CXCL1 |
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| EK5299 | SAB | 96 tests | EUR 663.6 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse CXCL1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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Mouse CXCL1/GROα ELISA kit |
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| LF-EK50473 | Abfrontier | 1×96T | EUR 777.6 |
Mouse CXCL1 PicoKine ELISA Kit |
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| EK0723 | BosterBio | 96 wells | EUR 547.2 |
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Description: For quantitative detection of mouse CXCL1 in cell culture supernates and serum. |
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Mouse CXCL1 Detection Assay Kit |
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| 6725 | Chondrex | 1 kit | EUR 580.26 |
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Description: Mouse CXCL1 Detection Assay Kit |
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CXCL1 protein (Mouse) (His tag) |
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| 80R-3368 | Fitzgerald | 50 ug | EUR 308.4 |
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Description: Purified recombinant CXCL1 protein (Mouse) (His tag) |
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CXCL1 protein (Mouse) (His tag) |
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| 80R-3439 | Fitzgerald | 50 ug | EUR 308.4 |
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Description: Purified recombinant CXCL1 protein (Mouse) (His tag) |
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Cxcl1 ORF Vector (Mouse) (pORF) |
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| ORF042286 | ABM | 1.0 ug DNA | EUR 114 |
Mouse CXCL1 AssayLite Antibody (FITC Conjugate) |
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| 70027-05141 | AssayPro | 150 ug | EUR 513.6 |
CXCL1 ELISA Kit (Mouse) (OKBB00312) |
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| OKBB00312 | Aviva Systems Biology | 96 Tests | EUR 652.8 |
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Description: Description of target: Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. The mature form of CXCL1 is maximally 73 amino acids long. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function. The standard product used in this kit is recombinant mouse CXCL1, consisting of 77 amino acids with the molecular mass of 8KDa.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/ml |
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CXCL1 ELISA Kit (Mouse) (OKAN04583) |
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| OKAN04583 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
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Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.0 pg/mL |
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CXCL1 ELISA Kit (Mouse) (OKCD05712) |
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| OKCD05712 | Aviva Systems Biology | 96 Wells | EUR 730.8 |
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Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.0pg/mL |
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Mouse CXCL1/GROα ELISA kit (4X96T) |
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| LF-EK50474 | Abfrontier | 4×96T | EUR 2641.2 |
Anti-GRO alpha/Cxcl1 Antibody |
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| A00533 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-GRO alpha/CXCL1 Antibody |
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| PA1760 | BosterBio | 100ug/vial | EUR 352.8 |
CXCL1 Antibody |
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| 43679-100ul | SAB | 100ul | EUR 302.4 |
CXCL1 antibody |
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| 70R-10502 | Fitzgerald | 50 ug | EUR 560.4 |
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Description: Affinity purified rabbit polyclonal CXCL1 antibody |
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CXCL1 antibody |
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| 70R-14297 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Affinity purified Rabbit polyclonal CXCL1 antibody |
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CXCL1 antibody |
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| 70R-16681 | Fitzgerald | 50 ul | EUR 522 |
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Description: Rabbit polyclonal CXCL1 antibody |
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CXCL1 antibody |
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| 70R-15473 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CXCL1 antibody |
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CXCL1 Antibody |
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| 33054-100ul | SAB | 100ul | EUR 302.4 |
CXCL1 Antibody |
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| 1-CSB-PA006239GA01HU | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
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CXCL1 Antibody |
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| 1-CSB-PA06097A0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA |
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CXCL1 Antibody |
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| 1-CSB-PA009036 | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
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Cxcl1 Antibody |
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| 1-CSB-PA09217A0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is Unconjugated. Tested in the following application: ELISA |
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GRO-alpha/CXCL1 (CHO-expressed), Mouse |
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| HY-P7186 | MedChemExpress | 50ug | EUR 404.4 |
Cxcl1 sgRNA CRISPR Lentivector set (Mouse) |
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| K4368201 | ABM | 3 x 1.0 ug | EUR 406.8 |
Mouse Growth-regulated alpha protein (Cxcl1) |
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| 1-CSB-RP092174m | Cusabio |
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Description: Recombinant Mouse Growth-regulated alpha protein(Cxcl1),partial expressed in E.coli |
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CXCL1 Protein Vector (Mouse) (pPM-C-HA) |
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| PV169144 | ABM | 500 ng | EUR 723.6 |
Cxcl1 ELISA Kit (Mouse) : 96 Wells (OKEH02714) |
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| OKEH02714 | Aviva Systems Biology | 96 Wells | EUR 652.8 |
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Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.76 pg/mL |
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CXCL1 Protein Vector (Mouse) (pPB-C-His) |
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| PV169142 | ABM | 500 ng | EUR 723.6 |
CXCL1 Protein Vector (Mouse) (pPB-N-His) |
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| PV169143 | ABM | 500 ng | EUR 723.6 |
CXCL1 Protein Vector (Mouse) (pPM-C-His) |
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| PV169145 | ABM | 500 ng | EUR 723.6 |
Nori® Mouse CXCL1/GRO-alpha ELISA Kit |
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| GR117324 | Genorise Scientific | 96-well | EUR 461 |
CXCL1 antibody (HRP) |
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| 60R-2236 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CXCL1 antibody (HRP) |
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Rabbit Anti Rat Cxcl1 Polyclonal Antibody |
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| CPBT-65101RR | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
CXCL1 antibody (FITC) |
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| 60R-2237 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CXCL1 antibody (FITC) |
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CXCL1/GRO |
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| EF012822 | Lifescience Market | 96 Tests | EUR 826.8 |
CXCL1/GRO |
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| E21-597 | EnoGene | 10ug | EUR 411.6 |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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| K4368202 | ABM | 1.0 ug DNA | EUR 184.8 |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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| K4368203 | ABM | 1.0 ug DNA | EUR 184.8 |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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| K4368204 | ABM | 1.0 ug DNA | EUR 184.8 |
CXCL1 antibody (biotin) |
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| 60R-2238 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CXCL1 antibody (biotin) |
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CXCL1 siRNA |
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| 20-abx913248 | Abbexa |
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CXCL1 siRNA |
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| 20-abx913249 | Abbexa |
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CXCL1 siRNA |
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| 20-abx901350 | Abbexa |
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pEGFP- CXCL1 |
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| PVT10178 | Lifescience Market | 2 ug | EUR 361.2 |
CXCL1 protein |
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| 30R-3156 | Fitzgerald | 50 ug | EUR 308.4 |
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Description: Purified recombinant CXCL1 protein |
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CXCL1 Peptide |
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| 42-129P | ProSci | 0.1 mg | EUR 405.6 |
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Description: (CT) CXCL1 Peptide |
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CXCL1 Conjugated Antibody |
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| C33054 | SAB | 100ul | EUR 476.4 |
Cxcl1 Polyclonal Antibody |
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| A51950 | EpiGentek |
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CXCL1 Polyclonal Antibody |
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| A51978 | EpiGentek |
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CXCL1 Chemi-Luminescent ELISA Kit (Mouse) (OKCD03823) |
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| OKCD03823 | Aviva Systems Biology | 96 Wells | EUR 1232.4 |
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Description: Description of target: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation . Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL |
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Mouse Cxcl1/ Growth-regulated alpha protein ELISA Kit |
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| E0354Mo | Sunlong | 1 Kit | EUR 655.2 |
Mouse Growth regulated alpha protein, Cxcl1 ELISA KIT |
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| ELI-04012m | Lifescience Market | 96 Tests | EUR 1038 |
GRO alpha (CXCL1) Antibody |
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| abx018005-100ug | Abbexa | 100 ug | EUR 410.4 |
Gro alpha Antibody / CXCL1 |
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| RQ4031 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: CXCL1 (Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-?). In humans, this protein is encoded by the CXCL1 gene. The CXCL1 gene is mapped on 4q13.3. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. It is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. Signaling through Cxcr2, Cxcl1 inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions. White matter expression of Cxcl1 was temporospatially regulated. Others contribute to aggressive growth selectivity in the lung. Among the lung metastasis signature genes identified, several, including CXCL1, were functionally validated. |
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Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit |
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| abx253956-96tests | Abbexa | 96 tests | EUR 801.6 |
Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit |
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| 20-abx154438 | Abbexa |
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Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit |
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| abx050043-96tests | Abbexa | 96 tests | EUR 924 |
Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit |
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| abx574645-96tests | Abbexa | 96 tests | EUR 801.6 |
Mouse CXCL1/GROα(Growth Regulated Oncogene Alpha) ELISA Kit |
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| EM0003 | FN Test | 96T | EUR 571.5 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml |
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CXCL1 Antibody, HRP conjugated |
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| 1-CSB-PA06097B0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
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Cxcl1 Antibody, HRP conjugated |
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| 1-CSB-PA09217B0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is HRP conjugated. Tested in the following application: ELISA |
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CXCL1 Antibody, FITC conjugated |
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| 1-CSB-PA06097C0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
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Cxcl1 Antibody, FITC conjugated |
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| 1-CSB-PA09217C0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is FITC conjugated. Tested in the following application: ELISA |
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CXCL1 Antibody, Biotin conjugated |
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| 1-CSB-PA06097D0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
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Cxcl1 Antibody, Biotin conjugated |
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| 1-CSB-PA09217D0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is Biotin conjugated. Tested in the following application: ELISA |
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Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-1mg |
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| QP1455-1mg | EnQuireBio | 1mg | EUR 3427.2 |
Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-5ug |
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| QP1455-5ug | EnQuireBio | 5ug | EUR 163.2 |
Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-20ug |
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| QP1455-20ug | EnQuireBio | 20ug | EUR 284.4 |
Mouse Growth Regulated Oncogene Alpha / GROa (CXCL1) CLIA Kit |
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| abx196070-96tests | Abbexa | 96 tests | EUR 990 |
CXCL1 cloning plasmid |
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| CSB-CL006239HU-10ug | Cusabio | 10ug | EUR 279.6 |
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Description: A cloning plasmid for the CXCL1 gene. |
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Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-1mg |
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| QP8650-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-100ug |
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| QP1455-100ug | EnQuireBio | 100ug | EUR 588 |
Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-500ug |
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| QP1455-500ug | EnQuireBio | 500ug | EUR 2133.6 |
CXCL1 Blocking Peptide |
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| 20-abx061039 | Abbexa |
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CXCL1 Blocking Peptide |
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| 33R-7741 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CXCL1 antibody, catalog no. 70R-10502 |
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Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-10ug |
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| QP8650-ec-10ug | EnQuireBio | 10ug | EUR 326.4 |
Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-50ug |
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| QP8650-ec-50ug | EnQuireBio | 50ug | EUR 434.4 |
Recombinant Human CXCL1 |
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| P0109 | FN Test | 100ug | EUR 626.83 |
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Description: Recombinant Human protein for CXCL1 |
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Breast cancer (BRCA) genetesting in ovarian cancer
The discovery of cancer-causing BRCA1/2 mutations and the emergence of genetic testing have brought precision in patient selection for poly-(ADP)-ribose polymerase inhibitor (PARPi) treatment. Interestingly, patients who are carriers of BRCA1/2 mutations have a higher risk for developing cancer, but respond better to DNA-damaging cytotoxic therapy, such as platinum-based chemotherapy.
The distinctive biology of ovarian cancer involves high genomic instability consisting of gene amplification, gene deletion, oncogene hypomethylation, loss of heterozygosity, and tumor suppressor gene promoter hypermethylation in many of the DNA damage response (DDR) genes, including BRCA1/2. Several of these genetic abnormalities can impair high fidelity DNA damage repair increasing the therapeutic audience for PARPi’s. This is especially important given the clinical development over the last decade of this group of agents and the dramatic increase in progression free survival among ovarian cancer patients who received PARPi, both in treatment or maintenance setting. In this review, we summarize our current understanding of the role of BRCA1/2 mutations in ovarian cancer and present relevant clinical trials in which BRCA1/2 was investigated as biomarker for therapy. We also outline the role of homologous recombination (HR) deficiency as biomarker by presenting the recent clinical development and recent approvals PARPi for firstline maintenance in ovarian cancer.
Haplotyping by linked-read sequencing (HLRS) of the genetic disease carriers for preimplantation genetictesting without a proband or relatives
Background: In order to mitigate the risk of allele dropout (ADO) and ensure the accuracy of preimplantation genetic testing for monogenic disease (PGT-M), it is necessary to construct parental haplotypes. Typically, haplotype resolution is obtained by genotyping multiple polymorphic markers in both parents and a proband or a relative. Sometimes, single sperm typing, or tests on the polar bodies may also be useful. Nevertheless, this process is time-consuming. At present, there was no simple linkage analysis strategy for patients without affected relatives.
Method: To solve this problem, we established a haplotyping by linked-read sequencing (HLRS) method without the requirement for additional relatives. First, the haplotype of the genetic disease carriers in the family was constructed by linked-read sequencing, and then the informative single nucleotide polymorphisms (SNPs) in upstream and downstream mutation region were selected to construct the embryo haplotype and to determine whether the embryo was carrying the mutation. Two families were selected to validate this method; one with alpha thalassemia and the other with NDP gene disorder.
Results: The haplotyping by linked-read sequencing (HLRS) method was successfully applied to construct parental haplotypes without recruiting additional family members; the method was also validated for PGT-M. The mutation carriers in these families were sequenced by linked-read sequencing, and their haplotypes were successfully phased. Adjacent SNPs of the mutation gene were identified.
The informative SNPs were chosen for linkage analyses to identify the carrier embryos. For the alpha thalassemia family, a normal blastocyst was transferred to the uterus and the accuracy of PGT-M was confirmed by amniocentesis at 16 weeks of gestation.
Conclusions: Our results suggest that HLRS can be applied for PGT-M of monogenic disorders or de novo mutations where the mutations haplotype cannot be determined due to absence of affected relatives.
anti- CD163/M130 Antibody |
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| FNab09771 | FN Test | 100µg | EUR 658.5 |
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Description: Antibody raised against CD163/M130 |
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Anti-Hu CD163 PE |
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| 1P-645-T025 | ExBio | 25 tests | EUR 168 |
Anti-Hu CD163 PE |
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| 1P-645-T100 | ExBio | 100 tests | EUR 288 |
Anti-Hu CD163 APC |
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| 1A-645-T025 | ExBio | 25 tests | EUR 168 |
Anti-Hu CD163 APC |
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| 1A-645-T100 | ExBio | 100 tests | EUR 288 |
Anti-Hu CD163 Purified |
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| 11-645-C025 | ExBio | 0.025 mg | EUR 118.8 |
Anti-Hu CD163 Purified |
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| 11-645-C100 | ExBio | 0.1 mg | EUR 189.6 |
Human CD163 ELISA Kit |
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| LF-EK50890 | Abfrontier | 1×96T | EUR 777.6 |
Human CD163 ELISA Kit |
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| ELA-E1726h | Lifescience Market | 96 Tests | EUR 988.8 |
Human CD163 shRNA Plasmid |
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| 20-abx956176 | Abbexa |
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Anti-Hu CD163 PE-Cy7 |
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| T7-645-T025 | ExBio | 25 tests | EUR 184.8 |
Anti-Hu CD163 PE-Cy7 |
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| T7-645-T100 | ExBio | 100 tests | EUR 321.6 |
Anti-Hu CD163 PerCP-Cy5.5 |
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| T9-645-T025 | ExBio | 25 tests | EUR 235.2 |
Anti-Hu CD163 PerCP-Cy5.5 |
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| T9-645-T100 | ExBio | 100 tests | EUR 422.4 |
PE Anti-human CD163 Antibody *GHI/61* |
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| 116301K0 | AAT Bioquest | 25 tests | EUR 383 |
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Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE Anti-human CD163 Antibody *GHI/61* |
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| 116301K1 | AAT Bioquest | 100 tests | EUR 995 |
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Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE Anti-human CD163 Antibody *GHI/61* |
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| 116301K2 | AAT Bioquest | 500 tests | EUR 2984 |
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Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE Anti-human CD163 Antibody *GHI/61* |
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| 116301K0-25tests | AAT Bioquest | 25 tests | EUR 383 |
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Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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PE Anti-human CD163 Antibody *GHI/61* |
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| 116301K1-100tests | AAT Bioquest | 100 tests | EUR 995 |
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Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PE Anti-human CD163 Antibody *GHI/61* |
|||
| 116301K2-500tests | AAT Bioquest | 500 tests | EUR 2984 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
APC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301B0 | AAT Bioquest | 25 tests | EUR 383 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
APC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301B1 | AAT Bioquest | 100 tests | EUR 995 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
APC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301B2 | AAT Bioquest | 500 tests | EUR 2984 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
APC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301B0-25tests | AAT Bioquest | 25 tests | EUR 383 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
APC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301B1-100tests | AAT Bioquest | 100 tests | EUR 995 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
APC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301B2-500tests | AAT Bioquest | 500 tests | EUR 2984 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
FITC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301G0 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
FITC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301G1 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
FITC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301G0-100tests | AAT Bioquest | 100 tests | EUR 547 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
FITC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301G1-500tests | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
TRITC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301H0 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
TRITC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301H1 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
| 116301S0 | AAT Bioquest | 25 tests | EUR 383 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
| 116301S1 | AAT Bioquest | 100 tests | EUR 995 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
| 116301S2 | AAT Bioquest | 500 tests | EUR 2984 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
TRITC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301H0-100tests | AAT Bioquest | 100 tests | EUR 547 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
TRITC Anti-human CD163 Antibody *GHI/61* |
|||
| 116301H1-500tests | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
| 116301S0-25tests | AAT Bioquest | 25 tests | EUR 383 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
| 116301S1-100tests | AAT Bioquest | 100 tests | EUR 995 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PerCP Anti-human CD163 Antibody *GHI/61* |
|||
| 116301S2-500tests | AAT Bioquest | 500 tests | EUR 2984 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PacBlue Anti-human CD163 Antibody *GHI/61* |
|||
| 116301I0 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
PacBlue Anti-human CD163 Antibody *GHI/61* |
|||
| 116301I1 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
PacBlue Anti-human CD163 Antibody *GHI/61* |
|||
| 116301I0-100tests | AAT Bioquest | 100 tests | EUR 547 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PacBlue Anti-human CD163 Antibody *GHI/61* |
|||
| 116301I1-500tests | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
Purified Anti-human CD163 Antibody *GHI/61* |
|||
| 11630000 | AAT Bioquest | 100 ug | EUR 365 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
Purified Anti-human CD163 Antibody *GHI/61* |
|||
| 11630000-100ug | AAT Bioquest | 100 ug | EUR 365 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PacOrange Anti-human CD163 Antibody *GHI/61* |
|||
| 116301J0 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
PacOrange Anti-human CD163 Antibody *GHI/61* |
|||
| 116301J1 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
PacOrange Anti-human CD163 Antibody *GHI/61* |
|||
| 116301J0-100tests | AAT Bioquest | 100 tests | EUR 547 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PacOrange Anti-human CD163 Antibody *GHI/61* |
|||
| 116301J1-500tests | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
Human CellExp? CD163, Human recombinant |
|||
| 9226-10 | Biovision | each | EUR 366 |
Human CellExp? CD163, Human recombinant |
|||
| 9226-50 | Biovision | each | EUR 927.6 |
Canine CD163 antigen(CD163 LISA kit |
|||
| GA-E0062CN-48T | GenAsia Biotech | 48T | EUR 482.4 |
Canine CD163 antigen(CD163 LISA kit |
|||
| GA-E0062CN-96T | GenAsia Biotech | 96T | EUR 820.8 |
Porcine CD163 antigen,CD163 LISA kit |
|||
| GA-E0045PC-48T | GenAsia Biotech | 48T | EUR 436.8 |
Porcine CD163 antigen,CD163 LISA kit |
|||
| GA-E0045PC-96T | GenAsia Biotech | 96T | EUR 708 |
Porcine CD163 antigen,CD163 LISA kit |
|||
| YLA0139PO-48T | Shanghai YL Biotech | 48T | EUR 502.5 |
Porcine CD163 antigen,CD163 LISA kit |
|||
| YLA0139PO-96T | Shanghai YL Biotech | 96T | EUR 618.75 |
ELISA kit for Human CD163 |
|||
| EK5296 | SAB | 96 tests | EUR 663.6 |
|
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CD163 in samples from serum, plasma, tissue homogenates and other biological fluids. |
|||
Human CD163 PicoKine ELISA Kit |
|||
| EK0715 | BosterBio | 96 wells | EUR 510 |
|
Description: For quantitative detection of human CD163 in cell culture supernates, serum and plasma(heparin). |
|||
CD163 Antibody |
|||
| 20-abx242956 | Abbexa |
|
|
CD163 antibody |
|||
| 10R-6496 | Fitzgerald | 100 ug | EUR 243.6 |
|
Description: Mouse monoclonal CD163 antibody |
|||
CD163 antibody |
|||
| 10R-CD163aRT | Fitzgerald | 250 ug | EUR 859.2 |
|
Description: Mouse monoclonal CD163 antibody |
|||
CD163 Antibody |
|||
| 37157-100ul | SAB | 100ul | EUR 302.4 |
CD163 Antibody |
|||
| 49553-100ul | SAB | 100ul | EUR 399.6 |
CD163 Antibody |
|||
| 49553-50ul | SAB | 50ul | EUR 286.8 |
CD163 Antibody |
|||
| ABD8235 | Lifescience Market | 100 ug | EUR 525.6 |
CD163 Antibody |
|||
| DF8235 | Affbiotech | 200ul | EUR 420 |
CD163 Antibody |
|||
| 1-CSB-PA969205 | Cusabio |
|
|
|
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100 |
|||
CD163 Antibody |
|||
| 1-CSB-PA801238LA01HU | Cusabio |
|
|
|
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200 |
|||
Cd163 Antibody |
|||
| 1-CSB-PA650452LA01MO | Cusabio |
|
|
|
Description: A polyclonal antibody against Cd163. Recognizes Cd163 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000 |
|||
CD163 Antibody |
|||
| F50316-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
|
Description: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. |
|||
CD163 Antibody |
|||
| F50316-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
|
Description: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. |
|||
CD163 Antibody |
|||
| RQ4259 | NSJ Bioreagents | 100 ug | EUR 356.15 |
|
Description: CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
|||
CD163 Antibody |
|||
| R30973 | NSJ Bioreagents | 100 ug | EUR 356.15 |
|
Description: CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants. CD163 is a scavenger receptor for the hemoglobin-haptoglobincomplex. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, Stover et al.(2000) mapped the CD163 gene to chromosome 12p13.3. Specific CD163-mediated endocytosis of haptoglobin-hemoglobin complexes was measurable in cells transfected with CD163 cDNA and in CD163-expressing myelomonocytic lymphoma cells.CD163 expression in monocytes promoted bacteria-induced proinflammatory cytokine production that could be blocked by anti-CD163 antibodies. Cells expressing human CD163 and recombinant protein containing the extracellular domain of CD163 supported adhesion of erythroblastic cells. |
|||
CD163 Antibody |
|||
| R30974 | NSJ Bioreagents | 100 ug | EUR 356.15 |
|
Description: Cluster of Differentiation 163, also known as Hemoglobin scavenger receptor, is a human protein encoded by the CD163 gene. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants. CD163 is a scavenger receptorfor the hemoglobin-haptoglobin complex. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, Stover et al.(2000) mapped the gene to chromosome 12p13.3. CD163 expression in monocytes promoted bacteria-induced proinflammatory cytokine production that could be blocked by CD163 antibody. Cells expressing human CD163 and recombinant protein containing the extracellular domain of CD163 supported adhesion of erythroblastic cells. |
|||
CD163 Antibody |
|||
| V3937-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V3937-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
|
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V3937SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| R20390-0.1ML | NSJ Bioreagents | 100ul | EUR 409 |
CD163 Antibody |
|||
| V7470-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V7470-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
|
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V7470IHC-7ML | NSJ Bioreagents | 7 ml | EUR 349.3 |
|
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V7470SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V8227-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V8227-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
|
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V8227SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
|||
CD163 Antibody |
|||
| V8415-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
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CD163 Antibody |
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| V8415-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
|
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
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CD163 Antibody |
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| V8415SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
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CD163 Antibody |
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| V8757-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
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CD163 Antibody |
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| V8757-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
|
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
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CD163 Antibody |
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| V8757SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
|
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
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CD163 ORF Vector (Human) (pORF) |
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| ORF017045 | ABM | 1.0 ug DNA | EUR 486 |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
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| 116301L0 | AAT Bioquest | 25 tests | EUR 429 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
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| 116301L1 | AAT Bioquest | 100 tests | EUR 1117 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
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| 116301L2 | AAT Bioquest | 500 tests | EUR 3351 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301M0 | AAT Bioquest | 25 tests | EUR 429 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301M1 | AAT Bioquest | 100 tests | EUR 1117 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301M2 | AAT Bioquest | 500 tests | EUR 3351 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
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| 116301L0-25tests | AAT Bioquest | 25 tests | EUR 429 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
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| 116301L1-100tests | AAT Bioquest | 100 tests | EUR 1117 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
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| 116301L2-500tests | AAT Bioquest | 500 tests | EUR 3351 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301M0-25tests | AAT Bioquest | 25 tests | EUR 429 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301M1-100tests | AAT Bioquest | 100 tests | EUR 1117 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301M2-500tests | AAT Bioquest | 500 tests | EUR 3351 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301C0 | AAT Bioquest | 25 tests | EUR 429 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301C1 | AAT Bioquest | 100 tests | EUR 1117 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
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| 116301C2 | AAT Bioquest | 500 tests | EUR 3351 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
| 116301C0-25tests | AAT Bioquest | 25 tests | EUR 429 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
| 116301C1-100tests | AAT Bioquest | 100 tests | EUR 1117 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
|||
| 116301C2-500tests | AAT Bioquest | 500 tests | EUR 3351 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
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| 116301T0 | AAT Bioquest | 25 tests | EUR 429 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
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| 116301T1 | AAT Bioquest | 100 tests | EUR 1117 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
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| 116301T2 | AAT Bioquest | 500 tests | EUR 3351 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
|||
| 116301T0-25tests | AAT Bioquest | 25 tests | EUR 429 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
|||
| 116301T1-100tests | AAT Bioquest | 100 tests | EUR 1117 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
|||
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
|||
| 116301T2-500tests | AAT Bioquest | 500 tests | EUR 3351 |
|
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
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Mouse Anti Rat Cd163 Monoclonal Antibody |
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| DMABT-47170MR | Creative Diagnostics | 0.25 mg | EUR 889.2 |
Mouse Anti Rat Cd163 Monoclonal Antibody |
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| DMABT-47171MR | Creative Diagnostics | 0.1 mg | EUR 670.8 |
CD163 ELISA Kit (Human) (OKBB00786) |
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| OKBB00786 | Aviva Systems Biology | 96 Wells | EUR 606 |
|
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml |
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CD163 ELISA Kit (Human) (OKAN04666) |
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| OKAN04666 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
|
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.273 ng/mL |
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CD163 ELISA Kit (Human) (OKBB01513) |
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| OKBB01513 | Aviva Systems Biology | 96 Wells | EUR 684 |
|
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml |
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CD163 ELISA Kit (Human) (OKCD07621) |
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| OKCD07621 | Aviva Systems Biology | 96 Wells | EUR 1123.2 |
|
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.273ng/mL |
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QuickDetect? CD163 (Human) ELISA Kit |
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| K4422-100 | Biovision | each | EUR 966 |
Anti-Human CD163 DyLight® 488 conjugated Antibody |
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| A00812-Dyl488 | BosterBio | 100ug/vial | EUR 412.8 |
Anti-Human CD163 DyLight® 550 conjugated Antibody |
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| A00812-Dyl550 | BosterBio | 100ug/vial | EUR 412.8 |
Mouse Anti-Human CD163 monoclonal antibody, clone JID274 |
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| CABT-L2938-100uL500uL | Creative Diagnostics | 100 uL, 500 uL | EUR 602.4 |
Nori® Human CD163 ELISA Kit |
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| GR111545 | Genorise Scientific | 96-well | EUR 461 |
iFluor® 350 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630010 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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iFluor® 350 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630011 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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iFluor® 405 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630020 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 405 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630021 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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iFluor® 430 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630030 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 430 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630031 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 450 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630040 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 450 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630041 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 488 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630050 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 488 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630051 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 514 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630060 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 514 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630061 | AAT Bioquest | 500 tests | EUR 2051 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
|||
iFluor® 532 Anti-human CD163 Antibody *GHI/61* |
|||
| 11630070 | AAT Bioquest | 100 tests | EUR 547 |
|
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
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