Tag: cdna lab
Implications of Genetic Testing in Dilated
Implications of Genetic Testing in Dilated Cardiomyopathy Background – Genetic analysis is a first-tier test in dilated cardiomyopathy (DCM). Electrical phenotypes are common in genetic DCM but their exact contribution to the clinical course and outcome is unknown. We determined the prevalence of pathogenic gene variants in a large unselected DCM population, and determined the role of electrical phenotypes […]
Structural and useful characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase
Structural and useful characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 perform by way of a novel non-competitive mechanism of motion Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 inside particular tumor microenvironments generates an immunosuppressive area of interest that successfully renders the […]